Abstract
The ability of a dioxin-like toxic compound, coplanar polychlorinated biphenyl, 3,3′,4,4′,5-pentachlorobiphenyl (PCB126) to reduce the protein level of hepatic class I alcohol dehydrogenase (ADH), which plays an important role in the metabolism of ethanol, was studied. Male Wistar rats received PCB126 25 mg/kg i.p. At this dose the compound induces a wasting syndrome. PCB126 administration resulted in a significant suppression of the protein level of class I ADH, whereas the difference between free- and pair-fed controls was slight. These results suggest that dioxins also reduce class I ADH without involvement of decreased food consumption. These data offer new insights into the toxicity of dioxins via a marked decrease in the level of class I ADH.
Original language | English |
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Pages (from-to) | 575-578 |
Number of pages | 4 |
Journal | Journal of Health Science |
Volume | 47 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2001 |
Externally published | Yes |
Keywords
- Alcohol dehydrogenase
- Dioxin
- Polychlorinated biphenyl
- Suppression
- Wasting syndrome
ASJC Scopus subject areas
- Toxicology
- Health, Toxicology and Mutagenesis