Abstract
The ability of a dioxin-like toxic compound, coplanar polychlorinated biphenyl, 3,3′,4,4′,5-pentachlorobiphenyl (PCB126) to reduce the protein level of hepatic class I alcohol dehydrogenase (ADH), which plays an important role in the metabolism of ethanol, was studied. Male Wistar rats received PCB126 25 mg/kg i.p. At this dose the compound induces a wasting syndrome. PCB126 administration resulted in a significant suppression of the protein level of class I ADH, whereas the difference between free- and pair-fed controls was slight. These results suggest that dioxins also reduce class I ADH without involvement of decreased food consumption. These data offer new insights into the toxicity of dioxins via a marked decrease in the level of class I ADH.
| Original language | English |
|---|---|
| Pages (from-to) | 575-578 |
| Number of pages | 4 |
| Journal | Journal of Health Science |
| Volume | 47 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2001 |
| Externally published | Yes |
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Keywords
- Alcohol dehydrogenase
- Dioxin
- Polychlorinated biphenyl
- Suppression
- Wasting syndrome
ASJC Scopus subject areas
- Toxicology
- Health, Toxicology and Mutagenesis
Cite this
Role of the dioxin-like toxic compound coplanar polychlorinated biphenyl,3,3′,4,4′,5-pentachlorobiphenyl in reducing hepatic alcohol dehydrogenase levels in rats in vivo. / Ishii, Yuji; Kato, Harutoshi; Hatsumura, Megumu; Ishida, Takumi; Ariyoshi, Noritaka; Yamada, Hideyuki; Oguri, Kazuta.
In: Journal of Health Science, Vol. 47, No. 6, 2001, p. 575-578.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Role of the dioxin-like toxic compound coplanar polychlorinated biphenyl,3,3′,4,4′,5-pentachlorobiphenyl in reducing hepatic alcohol dehydrogenase levels in rats in vivo
AU - Ishii, Yuji
AU - Kato, Harutoshi
AU - Hatsumura, Megumu
AU - Ishida, Takumi
AU - Ariyoshi, Noritaka
AU - Yamada, Hideyuki
AU - Oguri, Kazuta
PY - 2001
Y1 - 2001
N2 - The ability of a dioxin-like toxic compound, coplanar polychlorinated biphenyl, 3,3′,4,4′,5-pentachlorobiphenyl (PCB126) to reduce the protein level of hepatic class I alcohol dehydrogenase (ADH), which plays an important role in the metabolism of ethanol, was studied. Male Wistar rats received PCB126 25 mg/kg i.p. At this dose the compound induces a wasting syndrome. PCB126 administration resulted in a significant suppression of the protein level of class I ADH, whereas the difference between free- and pair-fed controls was slight. These results suggest that dioxins also reduce class I ADH without involvement of decreased food consumption. These data offer new insights into the toxicity of dioxins via a marked decrease in the level of class I ADH.
AB - The ability of a dioxin-like toxic compound, coplanar polychlorinated biphenyl, 3,3′,4,4′,5-pentachlorobiphenyl (PCB126) to reduce the protein level of hepatic class I alcohol dehydrogenase (ADH), which plays an important role in the metabolism of ethanol, was studied. Male Wistar rats received PCB126 25 mg/kg i.p. At this dose the compound induces a wasting syndrome. PCB126 administration resulted in a significant suppression of the protein level of class I ADH, whereas the difference between free- and pair-fed controls was slight. These results suggest that dioxins also reduce class I ADH without involvement of decreased food consumption. These data offer new insights into the toxicity of dioxins via a marked decrease in the level of class I ADH.
KW - Alcohol dehydrogenase
KW - Dioxin
KW - Polychlorinated biphenyl
KW - Suppression
KW - Wasting syndrome
UR - http://www.scopus.com/inward/record.url?scp=0035209213&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035209213&partnerID=8YFLogxK
U2 - 10.1248/jhs.47.575
DO - 10.1248/jhs.47.575
M3 - Article
AN - SCOPUS:0035209213
VL - 47
SP - 575
EP - 578
JO - Journal of Health Science
JF - Journal of Health Science
SN - 1344-9702
IS - 6
ER -