Role of the dioxin-like toxic compound coplanar polychlorinated biphenyl,3,3′,4,4′,5-pentachlorobiphenyl in reducing hepatic alcohol dehydrogenase levels in rats in vivo

Yuji Ishii, Harutoshi Kato, Megumu Hatsumura, Takumi Ishida, Noritaka Ariyoshi, Hideyuki Yamada, Kazuta Oguri

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The ability of a dioxin-like toxic compound, coplanar polychlorinated biphenyl, 3,3′,4,4′,5-pentachlorobiphenyl (PCB126) to reduce the protein level of hepatic class I alcohol dehydrogenase (ADH), which plays an important role in the metabolism of ethanol, was studied. Male Wistar rats received PCB126 25 mg/kg i.p. At this dose the compound induces a wasting syndrome. PCB126 administration resulted in a significant suppression of the protein level of class I ADH, whereas the difference between free- and pair-fed controls was slight. These results suggest that dioxins also reduce class I ADH without involvement of decreased food consumption. These data offer new insights into the toxicity of dioxins via a marked decrease in the level of class I ADH.

Original languageEnglish
Pages (from-to)575-578
Number of pages4
JournalJournal of Health Science
Volume47
Issue number6
DOIs
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Dioxins
Alcohol Dehydrogenase
Poisons
Polychlorinated Biphenyls
Rats
Liver
Wasting Syndrome
Metabolism
Toxicity
Wistar Rats
Proteins
Ethanol
Food

Keywords

  • Alcohol dehydrogenase
  • Dioxin
  • Polychlorinated biphenyl
  • Suppression
  • Wasting syndrome

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Role of the dioxin-like toxic compound coplanar polychlorinated biphenyl,3,3′,4,4′,5-pentachlorobiphenyl in reducing hepatic alcohol dehydrogenase levels in rats in vivo. / Ishii, Yuji; Kato, Harutoshi; Hatsumura, Megumu; Ishida, Takumi; Ariyoshi, Noritaka; Yamada, Hideyuki; Oguri, Kazuta.

In: Journal of Health Science, Vol. 47, No. 6, 2001, p. 575-578.

Research output: Contribution to journalArticle

Ishii, Yuji ; Kato, Harutoshi ; Hatsumura, Megumu ; Ishida, Takumi ; Ariyoshi, Noritaka ; Yamada, Hideyuki ; Oguri, Kazuta. / Role of the dioxin-like toxic compound coplanar polychlorinated biphenyl,3,3′,4,4′,5-pentachlorobiphenyl in reducing hepatic alcohol dehydrogenase levels in rats in vivo. In: Journal of Health Science. 2001 ; Vol. 47, No. 6. pp. 575-578.
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