Role of substance P in hypersensitivity reactions induced by paclitaxel, an anticancer agent

Toshiaki Sendo, Yoshinori Itoh, Takeshi Goromaru, Toshio Hirakawa, Mawako Ishida, Hitoo Nakano, Ryozo Oishi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The role of substance P in adverse pulmonary reactions induced by an anticancer agent paclitaxel was investigated in rats and humans who undertook post-operative chemotherapy for ovarian cancer. In rats, paclitaxel caused a marked plasma extravasation and edema in lungs with a concomitant decrease in arterial partial oxygen pressure, which were reversed by an NK1 antagonist LY303870. Substance P level in rat plasma and bronchoalveolar lavage fluid increased after paclitaxel injection. In 13 patients, plasma level of substance P but not histamine significantly (P

Original languageEnglish
Pages (from-to)1205-1208
Number of pages4
JournalPeptides
Volume25
Issue number7
DOIs
Publication statusPublished - Jul 2004
Externally publishedYes

Fingerprint

Substance P
Paclitaxel
Antineoplastic Agents
Rats
Hypersensitivity
Plasmas
1-(N-(2-methoxybenzyl)acetylamino)-3-(1H-indol-3-yl)-2-(N-(2-(4-(piperidin-1-yl)piperidin-1-yl)acetyl)amino)propane
Lung
Chemotherapy
Partial Pressure
Bronchoalveolar Lavage Fluid
Ovarian Neoplasms
Histamine
Edema
Oxygen
Drug Therapy
Injections
Fluids

Keywords

  • Acute lung injury
  • Histamine
  • Hypersensitivity
  • NK antagonist
  • Paclitaxel
  • Plasma extravasation
  • Substance P

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Sendo, T., Itoh, Y., Goromaru, T., Hirakawa, T., Ishida, M., Nakano, H., & Oishi, R. (2004). Role of substance P in hypersensitivity reactions induced by paclitaxel, an anticancer agent. Peptides, 25(7), 1205-1208. https://doi.org/10.1016/j.peptides.2004.04.004

Role of substance P in hypersensitivity reactions induced by paclitaxel, an anticancer agent. / Sendo, Toshiaki; Itoh, Yoshinori; Goromaru, Takeshi; Hirakawa, Toshio; Ishida, Mawako; Nakano, Hitoo; Oishi, Ryozo.

In: Peptides, Vol. 25, No. 7, 07.2004, p. 1205-1208.

Research output: Contribution to journalArticle

Sendo, T, Itoh, Y, Goromaru, T, Hirakawa, T, Ishida, M, Nakano, H & Oishi, R 2004, 'Role of substance P in hypersensitivity reactions induced by paclitaxel, an anticancer agent', Peptides, vol. 25, no. 7, pp. 1205-1208. https://doi.org/10.1016/j.peptides.2004.04.004
Sendo, Toshiaki ; Itoh, Yoshinori ; Goromaru, Takeshi ; Hirakawa, Toshio ; Ishida, Mawako ; Nakano, Hitoo ; Oishi, Ryozo. / Role of substance P in hypersensitivity reactions induced by paclitaxel, an anticancer agent. In: Peptides. 2004 ; Vol. 25, No. 7. pp. 1205-1208.
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