Role of substance P in hypersensitivity reactions induced by paclitaxel, an anticancer agent

Toshiaki Sendo, Yoshinori Itoh, Takeshi Goromaru, Toshio Hirakawa, Mawako Ishida, Hitoo Nakano, Ryozo Oishi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The role of substance P in adverse pulmonary reactions induced by an anticancer agent paclitaxel was investigated in rats and humans who undertook post-operative chemotherapy for ovarian cancer. In rats, paclitaxel caused a marked plasma extravasation and edema in lungs with a concomitant decrease in arterial partial oxygen pressure, which were reversed by an NK1 antagonist LY303870. Substance P level in rat plasma and bronchoalveolar lavage fluid increased after paclitaxel injection. In 13 patients, plasma level of substance P but not histamine significantly (P<0.05) increased during paclitaxel infusion. Therefore, substance P rather than histamine may be involved in paclitaxel hypersensitivity.

Original languageEnglish
Pages (from-to)1205-1208
Number of pages4
JournalPeptides
Volume25
Issue number7
DOIs
Publication statusPublished - Jul 2004

Keywords

  • Acute lung injury
  • Histamine
  • Hypersensitivity
  • NK antagonist
  • Paclitaxel
  • Plasma extravasation
  • Substance P

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Role of substance P in hypersensitivity reactions induced by paclitaxel, an anticancer agent'. Together they form a unique fingerprint.

  • Cite this

    Sendo, T., Itoh, Y., Goromaru, T., Hirakawa, T., Ishida, M., Nakano, H., & Oishi, R. (2004). Role of substance P in hypersensitivity reactions induced by paclitaxel, an anticancer agent. Peptides, 25(7), 1205-1208. https://doi.org/10.1016/j.peptides.2004.04.004