Role of neurokinin 3 receptor signaling in oral squamous cell carcinoma

Kyoichi Obata, Tsuyoshi Shimo, Tatsuo Okui, Kenichi Matsumoto, Hiroyuki Takada, Kiyofumi Takabatake, Yuki Kunisada, Soichiro Ibaragi, Norie Yoshioka, Koji Kishimoto, Hitoshi Nagatsuka, Akira Sasaki

Research output: Contribution to journalArticle

Abstract

Background/Aim: The neurokinin 3 receptor (NK-3R) is differentially expressed in the central nervous system including cases of human oral squamous cell carcinoma. However, the role of NK-3R signaling in oral squamous cell carcinoma is not well known. Materials and Methods: NK-3R expression in surgically resected oral squamous cell carcinoma was examined immunohistochemically and the strength of the expression was quantified. We evaluated the function of NK-3R signaling using NK-3R antagonist in human oral squamous cell carcinoma bone invasion mouse model. Results: NK-3R was significantly expressed in tumor cells that had invaded the bone matrix compared to the oral side tumor cells. SB222200, a selective antagonist of NK-3R, significantly suppressed the radiographic osteolytic lesion and tumorigenesis. Conclusion: NK-3R signaling is a potential target for the treatment of oral squamous cell carcinoma in cases of bone destruction.

Original languageEnglish
Pages (from-to)6119-6123
Number of pages5
JournalAnticancer Research
Volume37
Issue number11
DOIs
Publication statusPublished - Nov 1 2017

Fingerprint

Neurokinin-3 Receptors
Squamous Cell Carcinoma
Bone and Bones
Bone Matrix
Neoplasms
Carcinogenesis
Central Nervous System

Keywords

  • Neurokinin 3 Receptor
  • Neurokinin B
  • Oral squamous cell carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Role of neurokinin 3 receptor signaling in oral squamous cell carcinoma. / Obata, Kyoichi; Shimo, Tsuyoshi; Okui, Tatsuo; Matsumoto, Kenichi; Takada, Hiroyuki; Takabatake, Kiyofumi; Kunisada, Yuki; Ibaragi, Soichiro; Yoshioka, Norie; Kishimoto, Koji; Nagatsuka, Hitoshi; Sasaki, Akira.

In: Anticancer Research, Vol. 37, No. 11, 01.11.2017, p. 6119-6123.

Research output: Contribution to journalArticle

@article{f30d53fa80574e7f80ba4e200901a724,
title = "Role of neurokinin 3 receptor signaling in oral squamous cell carcinoma",
abstract = "Background/Aim: The neurokinin 3 receptor (NK-3R) is differentially expressed in the central nervous system including cases of human oral squamous cell carcinoma. However, the role of NK-3R signaling in oral squamous cell carcinoma is not well known. Materials and Methods: NK-3R expression in surgically resected oral squamous cell carcinoma was examined immunohistochemically and the strength of the expression was quantified. We evaluated the function of NK-3R signaling using NK-3R antagonist in human oral squamous cell carcinoma bone invasion mouse model. Results: NK-3R was significantly expressed in tumor cells that had invaded the bone matrix compared to the oral side tumor cells. SB222200, a selective antagonist of NK-3R, significantly suppressed the radiographic osteolytic lesion and tumorigenesis. Conclusion: NK-3R signaling is a potential target for the treatment of oral squamous cell carcinoma in cases of bone destruction.",
keywords = "Neurokinin 3 Receptor, Neurokinin B, Oral squamous cell carcinoma",
author = "Kyoichi Obata and Tsuyoshi Shimo and Tatsuo Okui and Kenichi Matsumoto and Hiroyuki Takada and Kiyofumi Takabatake and Yuki Kunisada and Soichiro Ibaragi and Norie Yoshioka and Koji Kishimoto and Hitoshi Nagatsuka and Akira Sasaki",
year = "2017",
month = "11",
day = "1",
doi = "10.21873/anticanres.12060",
language = "English",
volume = "37",
pages = "6119--6123",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "11",

}

TY - JOUR

T1 - Role of neurokinin 3 receptor signaling in oral squamous cell carcinoma

AU - Obata, Kyoichi

AU - Shimo, Tsuyoshi

AU - Okui, Tatsuo

AU - Matsumoto, Kenichi

AU - Takada, Hiroyuki

AU - Takabatake, Kiyofumi

AU - Kunisada, Yuki

AU - Ibaragi, Soichiro

AU - Yoshioka, Norie

AU - Kishimoto, Koji

AU - Nagatsuka, Hitoshi

AU - Sasaki, Akira

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Background/Aim: The neurokinin 3 receptor (NK-3R) is differentially expressed in the central nervous system including cases of human oral squamous cell carcinoma. However, the role of NK-3R signaling in oral squamous cell carcinoma is not well known. Materials and Methods: NK-3R expression in surgically resected oral squamous cell carcinoma was examined immunohistochemically and the strength of the expression was quantified. We evaluated the function of NK-3R signaling using NK-3R antagonist in human oral squamous cell carcinoma bone invasion mouse model. Results: NK-3R was significantly expressed in tumor cells that had invaded the bone matrix compared to the oral side tumor cells. SB222200, a selective antagonist of NK-3R, significantly suppressed the radiographic osteolytic lesion and tumorigenesis. Conclusion: NK-3R signaling is a potential target for the treatment of oral squamous cell carcinoma in cases of bone destruction.

AB - Background/Aim: The neurokinin 3 receptor (NK-3R) is differentially expressed in the central nervous system including cases of human oral squamous cell carcinoma. However, the role of NK-3R signaling in oral squamous cell carcinoma is not well known. Materials and Methods: NK-3R expression in surgically resected oral squamous cell carcinoma was examined immunohistochemically and the strength of the expression was quantified. We evaluated the function of NK-3R signaling using NK-3R antagonist in human oral squamous cell carcinoma bone invasion mouse model. Results: NK-3R was significantly expressed in tumor cells that had invaded the bone matrix compared to the oral side tumor cells. SB222200, a selective antagonist of NK-3R, significantly suppressed the radiographic osteolytic lesion and tumorigenesis. Conclusion: NK-3R signaling is a potential target for the treatment of oral squamous cell carcinoma in cases of bone destruction.

KW - Neurokinin 3 Receptor

KW - Neurokinin B

KW - Oral squamous cell carcinoma

UR - http://www.scopus.com/inward/record.url?scp=85032484174&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85032484174&partnerID=8YFLogxK

U2 - 10.21873/anticanres.12060

DO - 10.21873/anticanres.12060

M3 - Article

C2 - 29061792

AN - SCOPUS:85032484174

VL - 37

SP - 6119

EP - 6123

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 11

ER -