Role of imaging cardiac innervation and receptors in heart failure

Takahiro Higuchi, Markus Schwaiger, Frank M. Bengel

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Involvement of the sympathetic nervous system in congestive heart failure is characterized by a vicious circle, where reduced cardiac output results in neurohumoral activation. The hyperadrenergic state in turn causes desensitization and downregulation of cardiac β-adrenergic receptors and alterations of postsynaptic signal transduction, which further impair myocardial performance. Alterations of presynaptic cardiac sympathetic innervation are also involved in this pathophysiologic process. Reduction of presynaptic catecholamine reuptake increases overexposure to catecholamines further and thereby contributes to disease progression.

Original languageEnglish
Title of host publicationCardiac PET and PET/CT Imaging
PublisherSpringer New York
Pages329-344
Number of pages16
ISBN (Print)9780387352756
DOIs
Publication statusPublished - Dec 1 2007
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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