Role of human cytochrome P450 (CYP) in the metabolic activation of nitrosamine derivatives: Application of genetically engineered Salmonella expressing human CYP

Medicine & Life Sciences

• Nitrosamines 100%
• Metabolic Activation 89%
• Salmonella 76%
• Cytochrome P-450 Enzyme System 71%
• Tobacco 69%
• Lung Neoplasms 46%
• Cytochrome P-450 CYP3A 33%
• N'-nitrosoanabasine 31%
• N'-nitrosoanatabine 31%
• Genetic Polymorphisms 30%
• N-nitrosopiperidine 27%
• N-Nitrosopyrrolidine 27%
• 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 22%
• Cytochrome P-450 CYP2C8 22%
• NADPH-Ferrihemoprotein Reductase 19%
• Diethylnitrosamine 19%
• Cytochrome P-450 CYP2C9 19%
• Cytochrome P-450 CYP2C19 19%
• Cytochrome P-450 CYP2E1 18%
• Cytochrome P-450 CYP1A2 18%
• Cytochrome P-450 CYP1A1 18%
• Cytochrome P-450 CYP2D6 18%
• Salmonella typhimurium 16%
• Gene Deletion 15%
• Smoke 14%
• Genes 11%
• Carcinogenesis 11%
• Alleles 10%
• Smoking 10%
• Healthy Volunteers 9%
• Mutation 8%
• Enzymes 8%