Role of endocrine cell microvesicles in intercellular chemical transuction

Yoshinori Moriyama, Akitsugu Yamamoto, Yutaka Tashiro, Masamitsu Futai

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Microvesicles (MVs) in endocrine cells are morphologically similar to neuronal synaptic vesicles. MVs were shown to contain proteins involved in neurotransmitter storage such as vacuolar H+-ATPase and neurotransmitter transporters, and ones in vesicular trafficking such as synaptobrevins and W-ethylmaleimide-sensitive fusion protein. Isolated MVs accumulate cell-specific neurotransmitters in an energy-dependent manner. Upon stimulation, the MVs may fuse with the plasma membrane and secrete the internal neurotransmitters. Thus, endocrine ceils possess an MV-mediated secretion system as an intercellular signal transducing system.

Original languageEnglish
Pages (from-to)155-165
Number of pages11
JournalBiological Chemistry Hoppe-Seyler
Volume377
Issue number3
Publication statusPublished - Dec 1 1996

Keywords

  • Endocrine
  • Exocytosis
  • Intercellular signal transduction
  • Microvesicles (mvs)
  • Neu retransmitter
  • Neurocrine
  • Paracrine
  • Secretory granules
  • Synaptic vesicles
  • Vacuolar-type h+-ajpase (v-atpase)
  • Vesicular transporters

ASJC Scopus subject areas

  • Biochemistry

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  • Cite this

    Moriyama, Y., Yamamoto, A., Tashiro, Y., & Futai, M. (1996). Role of endocrine cell microvesicles in intercellular chemical transuction. Biological Chemistry Hoppe-Seyler, 377(3), 155-165.