Role of endocrine cell microvesicles in intercellular chemical transuction

Yoshinori Moriyama, Akitsugu Yamamoto, Yutaka Tashiro, Masamitsu Futai

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

Microvesicles (MVs) in endocrine cells are morphologically similar to neuronal synaptic vesicles. MVs were shown to contain proteins involved in neurotransmitter storage such as vacuolar H+-ATPase and neurotransmitter transporters, and ones in vesicular trafficking such as synaptobrevins and W-ethylmaleimide-sensitive fusion protein. Isolated MVs accumulate cell-specific neurotransmitters in an energy-dependent manner. Upon stimulation, the MVs may fuse with the plasma membrane and secrete the internal neurotransmitters. Thus, endocrine ceils possess an MV-mediated secretion system as an intercellular signal transducing system.

Original languageEnglish
Pages (from-to)155-165
Number of pages11
JournalBiological Chemistry Hoppe-Seyler
Volume377
Issue number3
Publication statusPublished - 1996

Keywords

  • Endocrine
  • Exocytosis
  • Intercellular signal transduction
  • Microvesicles (mvs)
  • Neu retransmitter
  • Neurocrine
  • Paracrine
  • Secretory granules
  • Synaptic vesicles
  • Vacuolar-type h+-ajpase (v-atpase)
  • Vesicular transporters

ASJC Scopus subject areas

  • Biochemistry

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