Role of early serial change in serum carcinoembryonic antigen levels as a predictive marker for radiological response to gefitinib in Japanese patients with non-small cell lung cancer

Katsuyuki Hotta, Katsuyuki Kiura, Masahiro Tabata, Nagio Takigawa, Yoshiro Fujiwara, Shigeki Umemura, Mitsune Tanimoto

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: There have been no reports evaluating the utility of monitoring early change in serum carcinoembryonic antigen (CEA) level as a predictor for subsequent radiological response to gefitinib in patients with non-small cell lung cancer. In this report, we investigated its role using the data from 110 non-small cell lung cancer (NSCLC) patients. Methods: The daily rate of CEA change was defined as: (M0-Mx)/Dx/M0x100(%), using the baseline level (M0), the level on day X (Mx), and the number of days from day 1 to day X (Dx). Results: The daily rate of CEA change until confirmation of an objective response was significantly higher in patients with an objective response or stable disease than progressive disease (PD) patients (p

Original languageEnglish
Pages (from-to)1737-1741
Number of pages5
JournalAnticancer Research
Volume27
Issue number3 B
Publication statusPublished - May 2007

Fingerprint

Carcinoembryonic Antigen
Non-Small Cell Lung Carcinoma
Serum
gefitinib

Keywords

  • Carcinoembryonic antigen
  • Gefitinib
  • Non-small cell lung cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Role of early serial change in serum carcinoembryonic antigen levels as a predictive marker for radiological response to gefitinib in Japanese patients with non-small cell lung cancer. / Hotta, Katsuyuki; Kiura, Katsuyuki; Tabata, Masahiro; Takigawa, Nagio; Fujiwara, Yoshiro; Umemura, Shigeki; Tanimoto, Mitsune.

In: Anticancer Research, Vol. 27, No. 3 B, 05.2007, p. 1737-1741.

Research output: Contribution to journalArticle

@article{c4b27599859c42219c2b9428d30a6010,
title = "Role of early serial change in serum carcinoembryonic antigen levels as a predictive marker for radiological response to gefitinib in Japanese patients with non-small cell lung cancer",
abstract = "Background: There have been no reports evaluating the utility of monitoring early change in serum carcinoembryonic antigen (CEA) level as a predictor for subsequent radiological response to gefitinib in patients with non-small cell lung cancer. In this report, we investigated its role using the data from 110 non-small cell lung cancer (NSCLC) patients. Methods: The daily rate of CEA change was defined as: (M0-Mx)/Dx/M0x100({\%}), using the baseline level (M0), the level on day X (Mx), and the number of days from day 1 to day X (Dx). Results: The daily rate of CEA change until confirmation of an objective response was significantly higher in patients with an objective response or stable disease than progressive disease (PD) patients (p",
keywords = "Carcinoembryonic antigen, Gefitinib, Non-small cell lung cancer",
author = "Katsuyuki Hotta and Katsuyuki Kiura and Masahiro Tabata and Nagio Takigawa and Yoshiro Fujiwara and Shigeki Umemura and Mitsune Tanimoto",
year = "2007",
month = "5",
language = "English",
volume = "27",
pages = "1737--1741",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "3 B",

}

TY - JOUR

T1 - Role of early serial change in serum carcinoembryonic antigen levels as a predictive marker for radiological response to gefitinib in Japanese patients with non-small cell lung cancer

AU - Hotta, Katsuyuki

AU - Kiura, Katsuyuki

AU - Tabata, Masahiro

AU - Takigawa, Nagio

AU - Fujiwara, Yoshiro

AU - Umemura, Shigeki

AU - Tanimoto, Mitsune

PY - 2007/5

Y1 - 2007/5

N2 - Background: There have been no reports evaluating the utility of monitoring early change in serum carcinoembryonic antigen (CEA) level as a predictor for subsequent radiological response to gefitinib in patients with non-small cell lung cancer. In this report, we investigated its role using the data from 110 non-small cell lung cancer (NSCLC) patients. Methods: The daily rate of CEA change was defined as: (M0-Mx)/Dx/M0x100(%), using the baseline level (M0), the level on day X (Mx), and the number of days from day 1 to day X (Dx). Results: The daily rate of CEA change until confirmation of an objective response was significantly higher in patients with an objective response or stable disease than progressive disease (PD) patients (p

AB - Background: There have been no reports evaluating the utility of monitoring early change in serum carcinoembryonic antigen (CEA) level as a predictor for subsequent radiological response to gefitinib in patients with non-small cell lung cancer. In this report, we investigated its role using the data from 110 non-small cell lung cancer (NSCLC) patients. Methods: The daily rate of CEA change was defined as: (M0-Mx)/Dx/M0x100(%), using the baseline level (M0), the level on day X (Mx), and the number of days from day 1 to day X (Dx). Results: The daily rate of CEA change until confirmation of an objective response was significantly higher in patients with an objective response or stable disease than progressive disease (PD) patients (p

KW - Carcinoembryonic antigen

KW - Gefitinib

KW - Non-small cell lung cancer

UR - http://www.scopus.com/inward/record.url?scp=34249322003&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34249322003&partnerID=8YFLogxK

M3 - Article

C2 - 17595807

AN - SCOPUS:34249322003

VL - 27

SP - 1737

EP - 1741

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 3 B

ER -