Role of CC chemokine CCL6/C10 as a monocyte chemoattractant in a murine acute peritonitis

Andrew M. LaFleur, Nicholas W. Lukacs, Steven L. Kunkel, Akihiro Matsukawa

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

THE aim of this study was to determine the role of CC chemokine CCL6/C10 in acute inflammation. Intraperitoneal injection of thioglycollate increased peritoneal CCL6, which peaked at 4 h and remained elevated at 48 h. Neutralization of CCL6 significantly inhibited the macrophage infiltration (34-48% reduction), but not other cell types, without decreasing the other CC chemokines known to attract monocytes/macrophages. CCL6 was expressed in peripheral eosinophils and elicited macrophages, but not in elicited neutrophils. Peritoneal CCL6 level was not decreased in granulocyte-depleted mice where eosinophil influx was significantly impaired. Thus, CGL6 appears to contribute to the macrophage infiltration that is independent of other CC chemokines. Eosinophils pre-store CCL6, but do not release CCL6 in the peritoneum in this model of inflammation.

Original languageEnglish
Pages (from-to)349-355
Number of pages7
JournalMediators of Inflammation
Volume13
Issue number5-6
DOIs
Publication statusPublished - Dec 1 2004
Externally publishedYes

Keywords

  • Acute inflammation
  • CC chemokines
  • Eosinophils
  • Monocytes/macrophages
  • Neutrophils

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

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