Role of CC chemokine CCL6/C10 as a monocyte chemoattractant in a murine acute peritonitis

Andrew M. LaFleur, Nicholas W. Lukacs, Steven L. Kunkel, Akihiro Matsukawa

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

THE aim of this study was to determine the role of CC chemokine CCL6/C10 in acute inflammation. Intraperitoneal injection of thioglycollate increased peritoneal CCL6, which peaked at 4 h and remained elevated at 48 h. Neutralization of CCL6 significantly inhibited the macrophage infiltration (34-48% reduction), but not other cell types, without decreasing the other CC chemokines known to attract monocytes/macrophages. CCL6 was expressed in peripheral eosinophils and elicited macrophages, but not in elicited neutrophils. Peritoneal CCL6 level was not decreased in granulocyte-depleted mice where eosinophil influx was significantly impaired. Thus, CGL6 appears to contribute to the macrophage infiltration that is independent of other CC chemokines. Eosinophils pre-store CCL6, but do not release CCL6 in the peritoneum in this model of inflammation.

Original languageEnglish
Pages (from-to)349-355
Number of pages7
JournalMediators of Inflammation
Volume13
Issue number5-6
DOIs
Publication statusPublished - Dec 2004
Externally publishedYes

Fingerprint

CC Chemokines
Chemotactic Factors
Peritonitis
Monocytes
Macrophages
Eosinophils
Inflammation
Thioglycolates
Peritoneum
Intraperitoneal Injections
Granulocytes
Neutrophils

Keywords

  • Acute inflammation
  • CC chemokines
  • Eosinophils
  • Monocytes/macrophages
  • Neutrophils

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

Role of CC chemokine CCL6/C10 as a monocyte chemoattractant in a murine acute peritonitis. / LaFleur, Andrew M.; Lukacs, Nicholas W.; Kunkel, Steven L.; Matsukawa, Akihiro.

In: Mediators of Inflammation, Vol. 13, No. 5-6, 12.2004, p. 349-355.

Research output: Contribution to journalArticle

LaFleur, Andrew M. ; Lukacs, Nicholas W. ; Kunkel, Steven L. ; Matsukawa, Akihiro. / Role of CC chemokine CCL6/C10 as a monocyte chemoattractant in a murine acute peritonitis. In: Mediators of Inflammation. 2004 ; Vol. 13, No. 5-6. pp. 349-355.
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