Role of apoptosis in renal injury

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Nephrologists are now investigating the involvement of apoptosis, or programmed cell death, in various renal diseases. Evidence suggests that abnormalities of apoptosis may contribute to the development of glomerular and tubular diseases. In tissue remodeling after glomerular injuries, excess apoptosis may be associated with cell deletion of glomerular sclerosis. Increased apoptosis may mediate the resolution of glomerular hypercellularity in experimental mesangial proliferation. Reactive oxygen species, deprivation of growth factors, anti-Thy 1 monoclonal antibodies and anti-Fas antibodies are capable of inducing apoptosis in cultured mesangial cells. In renal tubular diseases, apoptosis may be associated with tubular atrophy after ureteral obstruction, tubular damage after ischemia-reperfusion or toxic drugs, and the development of polycystic kidney disease. Infiltrative leukocytes in the glomerulus and renal interstitium undergo apoptosis during inflammation. Thus, apoptosis appears to play a significant role in many renal diseases, and we should consider the regulation of apoptosis in the treatment of these disorders.

Original languageEnglish
Pages (from-to)1975-1981
Number of pages7
JournalNihon rinsho. Japanese journal of clinical medicine
Volume54
Issue number7
Publication statusPublished - Jul 1996

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Apoptosis
Kidney
Wounds and Injuries
Ureteral Obstruction
Polycystic Kidney Diseases
Mesangial Cells
Poisons
Sclerosis
Reperfusion
Atrophy
Anti-Idiotypic Antibodies
Cultured Cells
Reactive Oxygen Species
Intercellular Signaling Peptides and Proteins
Leukocytes
Cell Death
Ischemia
Monoclonal Antibodies
Inflammation
Pharmaceutical Preparations

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Role of apoptosis in renal injury. / Sugiyama, Hitoshi; Kashihara, N.; Makino, Hirofumi.

In: Nihon rinsho. Japanese journal of clinical medicine, Vol. 54, No. 7, 07.1996, p. 1975-1981.

Research output: Contribution to journalArticle

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