Role of angiontensin receptors on remodeling perivascular nerves

Narumi Hobara, Mitsuhiro Goda, Naoya Hashikawa, Xin Jin, Yoshito Zamami, Shingo Takatori, Hiromu Kawasaki

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The aim of this study was to investigate age-related changes in the density of calcitonin gene-related peptide (CGRP)-containing nerve fibers in spontaneously hypertensive rats (SHR) and the effects of long-term inhibition of the renin-angiotensin system on these changes. An age-related decrease in the density of CGRP-like immunoreactive (LI)-containing nerve fibers but not neuropeptide Y (NPY)-LI-containing sympathetic nerve fibers was found in the mesenteric artery of SHR but not Wistar-Kyoto rats (WKY). The density of NPY-LI-containing nerve fibers was significantly greater in SHR than in WKY. SHR were treated for 7 weeks with angiotensin-converting enzyme inhibitor (0.005% temocapril), angiotensin II type-1 (AT1) receptor antagonist (0.025% losartan), or vasodilator (0.01% hydralazine) in their drinking water. Each drug treatment significantly lowered the systolic blood pressure measured using the tail-cuff method. Long-term treatment of SHR with temocapril and losartan significantly increased the density of CGRP-LI-containing nerve fibers in mesenteric arteries. Furthermore, to clarify the effect of the angiontensin II type-2 (AT2) receptor in the restoration of perivascular nerve innervation, we used the phenol-injured rat model, in which the perivascular nerves are markedly reduced by the topical application of phenol. Activation of AT2R significantly restored CGRP-LI innervation in phenol-injured rats. These results suggest that selective stimulation of AT2 receptors facilitates reinnervation of mesenteric perivascular CGRP-containing nerves.

Original languageEnglish
Pages (from-to)1421-1425
Number of pages5
JournalYakugaku Zasshi
Volume130
Issue number11
DOIs
Publication statusPublished - Nov 2010

Fingerprint

Calcitonin Gene-Related Peptide
Inbred SHR Rats
Nerve Fibers
Phenol
Mesenteric Arteries
Losartan
Inbred WKY Rats
Neuropeptide Y
Blood Pressure
Adrenergic Fibers
Angiotensin II Type 1 Receptor Blockers
Hydralazine
Renin-Angiotensin System
Vasodilator Agents
Angiotensin-Converting Enzyme Inhibitors
Drinking Water
Tail
Pharmaceutical Preparations
temocapril hydrochloride

Keywords

  • Angiotensin II type 2 receptor
  • Calcitonin gene-related peptide
  • Hypertension
  • Nerve regeneration
  • Renin-angiotensin system

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

Cite this

Hobara, N., Goda, M., Hashikawa, N., Jin, X., Zamami, Y., Takatori, S., & Kawasaki, H. (2010). Role of angiontensin receptors on remodeling perivascular nerves. Yakugaku Zasshi, 130(11), 1421-1425. https://doi.org/10.1248/yakushi.130.1421

Role of angiontensin receptors on remodeling perivascular nerves. / Hobara, Narumi; Goda, Mitsuhiro; Hashikawa, Naoya; Jin, Xin; Zamami, Yoshito; Takatori, Shingo; Kawasaki, Hiromu.

In: Yakugaku Zasshi, Vol. 130, No. 11, 11.2010, p. 1421-1425.

Research output: Contribution to journalArticle

Hobara, N, Goda, M, Hashikawa, N, Jin, X, Zamami, Y, Takatori, S & Kawasaki, H 2010, 'Role of angiontensin receptors on remodeling perivascular nerves', Yakugaku Zasshi, vol. 130, no. 11, pp. 1421-1425. https://doi.org/10.1248/yakushi.130.1421
Hobara N, Goda M, Hashikawa N, Jin X, Zamami Y, Takatori S et al. Role of angiontensin receptors on remodeling perivascular nerves. Yakugaku Zasshi. 2010 Nov;130(11):1421-1425. https://doi.org/10.1248/yakushi.130.1421
Hobara, Narumi ; Goda, Mitsuhiro ; Hashikawa, Naoya ; Jin, Xin ; Zamami, Yoshito ; Takatori, Shingo ; Kawasaki, Hiromu. / Role of angiontensin receptors on remodeling perivascular nerves. In: Yakugaku Zasshi. 2010 ; Vol. 130, No. 11. pp. 1421-1425.
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