Role of active oxygen species in diethyldithiocarbamate-induced gastric ulcer in the rat

S. Oka; K. Ogino; T. Hobara; S. Yoshimura; H. Yanai; Y. Okazaki; T. Takemoto; H. Ishiyama; T. Imaizumi; K. Yamasaki; T. Kanbe

doi:10.1007/BF01951766

Role of active oxygen species in diethyldithiocarbamate-induced gastric ulcer in the rat

S. Oka, K. Ogino, T. Hobara, S. Yoshimura, H. Yanai, Y. Okazaki, T. Takemoto, H. Ishiyama, T. Imaizumi, K. Yamasaki, T. Kanbe

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Diethyldithiocarbamate, an inhibitor of Cu,Zn-superoxide dismutase, was recently found to be ulcerogenic in the rat stomach, and active oxygen species were found to be responsible for its ulcerogenicity. To clarify which active oxygen species play a role in ulcerogenesis, the effects of various scavengers and iron-chelators were studied. As superoxide dismutase and catalase reduced the ulcerogenesis induced by diethyldithiocarbamate, the superoxide radical and hydrogen peroxide were considered to play a pathogenic role in this ulcer model.

Original language	English
Pages (from-to)	281-283
Number of pages	3
Journal	Experientia
Volume	46
Issue number	3
DOIs	https://doi.org/10.1007/BF01951766
Publication status	Published - Mar 1 1990

Keywords

Diethyldithiocarbamate
catalase
gastric ulcer
superoxide dismutase

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1007/BF01951766

Cite this

@article{5d721db242684f37a98b3f1e975c0f30,

title = "Role of active oxygen species in diethyldithiocarbamate-induced gastric ulcer in the rat",

abstract = "Diethyldithiocarbamate, an inhibitor of Cu,Zn-superoxide dismutase, was recently found to be ulcerogenic in the rat stomach, and active oxygen species were found to be responsible for its ulcerogenicity. To clarify which active oxygen species play a role in ulcerogenesis, the effects of various scavengers and iron-chelators were studied. As superoxide dismutase and catalase reduced the ulcerogenesis induced by diethyldithiocarbamate, the superoxide radical and hydrogen peroxide were considered to play a pathogenic role in this ulcer model.",

keywords = "Diethyldithiocarbamate, catalase, gastric ulcer, superoxide dismutase",

author = "S. Oka and K. Ogino and T. Hobara and S. Yoshimura and H. Yanai and Y. Okazaki and T. Takemoto and H. Ishiyama and T. Imaizumi and K. Yamasaki and T. Kanbe",

year = "1990",

month = mar,

day = "1",

doi = "10.1007/BF01951766",

language = "English",

volume = "46",

pages = "281--283",

journal = "Cellular and Molecular Life Sciences",

issn = "1420-682X",

publisher = "Birkhauser Verlag Basel",

number = "3",

}

TY - JOUR

T1 - Role of active oxygen species in diethyldithiocarbamate-induced gastric ulcer in the rat

AU - Oka, S.

AU - Ogino, K.

AU - Hobara, T.

AU - Yoshimura, S.

AU - Yanai, H.

AU - Okazaki, Y.

AU - Takemoto, T.

AU - Ishiyama, H.

AU - Imaizumi, T.

AU - Yamasaki, K.

AU - Kanbe, T.

PY - 1990/3/1

Y1 - 1990/3/1

N2 - Diethyldithiocarbamate, an inhibitor of Cu,Zn-superoxide dismutase, was recently found to be ulcerogenic in the rat stomach, and active oxygen species were found to be responsible for its ulcerogenicity. To clarify which active oxygen species play a role in ulcerogenesis, the effects of various scavengers and iron-chelators were studied. As superoxide dismutase and catalase reduced the ulcerogenesis induced by diethyldithiocarbamate, the superoxide radical and hydrogen peroxide were considered to play a pathogenic role in this ulcer model.

AB - Diethyldithiocarbamate, an inhibitor of Cu,Zn-superoxide dismutase, was recently found to be ulcerogenic in the rat stomach, and active oxygen species were found to be responsible for its ulcerogenicity. To clarify which active oxygen species play a role in ulcerogenesis, the effects of various scavengers and iron-chelators were studied. As superoxide dismutase and catalase reduced the ulcerogenesis induced by diethyldithiocarbamate, the superoxide radical and hydrogen peroxide were considered to play a pathogenic role in this ulcer model.

KW - Diethyldithiocarbamate

KW - catalase

KW - gastric ulcer

KW - superoxide dismutase

UR - http://www.scopus.com/inward/record.url?scp=0025341855&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025341855&partnerID=8YFLogxK

U2 - 10.1007/BF01951766

DO - 10.1007/BF01951766

M3 - Article

C2 - 2155813

AN - SCOPUS:0025341855

SN - 1420-682X

VL - 46

SP - 281

EP - 283

JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

IS - 3

ER -

Role of active oxygen species in diethyldithiocarbamate-induced gastric ulcer in the rat

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this