Role of γδ T cells in protecting normal airway function

Willi K. Born, Michael Lahn, Katsuyuki Takeda, Arihiko Kanehiro, Rebecca L. O'Brien, Erwin W. Gelfand

Research output: Contribution to journalReview article

44 Citations (Scopus)

Abstract

Since their discovery 15 years ago, the role of γδ T cells has remained somewhat elusive. Responses of γδ T cells have been found in numerous infectious and non-infectious diseases. New evidence points to γδ T cells' functioning in the airways to maintain normal airway responsiveness or tone. In the lung, distinct subsets of γδ T cell subsets seem to have specific roles, one subset promoting allergic inflammation, the other serving a protective role.

Original languageEnglish
Pages (from-to)151-158
Number of pages8
JournalRespiratory Research
Volume1
Issue number1
DOIs
Publication statusPublished - Nov 7 2000

Keywords

  • Airway hyper-responsiveness
  • Asthma
  • Lymphocytes
  • γδ T cells

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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  • Cite this

    Born, W. K., Lahn, M., Takeda, K., Kanehiro, A., O'Brien, R. L., & Gelfand, E. W. (2000). Role of γδ T cells in protecting normal airway function. Respiratory Research, 1(1), 151-158. https://doi.org/10.1186/rr26