Role of γδ T cells in protecting normal airway function

Willi K. Born; Michael Lahn; Katsuyuki Takeda; Arihiko Kanehiro; Rebecca L. O'Brien; Erwin W. Gelfand

doi:10.1186/rr26

Role of γδ T cells in protecting normal airway function

Willi K. Born, Michael Lahn, Katsuyuki Takeda, Arihiko Kanehiro, Rebecca L. O'Brien, Erwin W. Gelfand

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Review article › peer-review

46 Citations (Scopus)

Abstract

Since their discovery 15 years ago, the role of γδ T cells has remained somewhat elusive. Responses of γδ T cells have been found in numerous infectious and non-infectious diseases. New evidence points to γδ T cells' functioning in the airways to maintain normal airway responsiveness or tone. In the lung, distinct subsets of γδ T cell subsets seem to have specific roles, one subset promoting allergic inflammation, the other serving a protective role.

Original language	English
Pages (from-to)	151-158
Number of pages	8
Journal	Respiratory Research
Volume	1
Issue number	1
DOIs	https://doi.org/10.1186/rr26
Publication status	Published - Nov 7 2000

Keywords

Airway hyper-responsiveness
Asthma
Lymphocytes
γδ T cells

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

Access to Document

10.1186/rr26

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AU - Gelfand, Erwin W.

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AB - Since their discovery 15 years ago, the role of γδ T cells has remained somewhat elusive. Responses of γδ T cells have been found in numerous infectious and non-infectious diseases. New evidence points to γδ T cells' functioning in the airways to maintain normal airway responsiveness or tone. In the lung, distinct subsets of γδ T cell subsets seem to have specific roles, one subset promoting allergic inflammation, the other serving a protective role.

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