Role of γδ T cells in protecting normal airway function

Willi K. Born, Michael Lahn, Katsuyuki Takeda, Arihiko Kanehiro, Rebecca L. O'Brien, Erwin W. Gelfand

Research output: Contribution to journalReview articlepeer-review

49 Citations (Scopus)


Since their discovery 15 years ago, the role of γδ T cells has remained somewhat elusive. Responses of γδ T cells have been found in numerous infectious and non-infectious diseases. New evidence points to γδ T cells' functioning in the airways to maintain normal airway responsiveness or tone. In the lung, distinct subsets of γδ T cell subsets seem to have specific roles, one subset promoting allergic inflammation, the other serving a protective role.

Original languageEnglish
Pages (from-to)151-158
Number of pages8
JournalRespiratory Research
Issue number1
Publication statusPublished - Nov 7 2000
Externally publishedYes


  • Airway hyper-responsiveness
  • Asthma
  • Lymphocytes
  • γδ T cells

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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