Role of γδ T cells in protecting normal airway function

Willi K. Born; Michael Lahn; Katsuyuki Takeda; Arihiko Kanehiro; Rebecca L. O'Brien; Erwin W. Gelfand

doi:10.1186/rr26

Role of γδ T cells in protecting normal airway function

Willi K. Born, Michael Lahn, Katsuyuki Takeda, Arihiko Kanehiro, Rebecca L. O'Brien, Erwin W. Gelfand

Research output: Contribution to journal › Review article › peer-review

48 Citations (Scopus)

Abstract

Since their discovery 15 years ago, the role of γδ T cells has remained somewhat elusive. Responses of γδ T cells have been found in numerous infectious and non-infectious diseases. New evidence points to γδ T cells' functioning in the airways to maintain normal airway responsiveness or tone. In the lung, distinct subsets of γδ T cell subsets seem to have specific roles, one subset promoting allergic inflammation, the other serving a protective role.

Original language	English
Pages (from-to)	151-158
Number of pages	8
Journal	Respiratory Research
Volume	1
Issue number	1
DOIs	https://doi.org/10.1186/rr26
Publication status	Published - Nov 7 2000
Externally published	Yes

Keywords

Airway hyper-responsiveness
Asthma
Lymphocytes
γδ T cells

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/rr26

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title = "Role of γδ T cells in protecting normal airway function",

abstract = "Since their discovery 15 years ago, the role of γδ T cells has remained somewhat elusive. Responses of γδ T cells have been found in numerous infectious and non-infectious diseases. New evidence points to γδ T cells' functioning in the airways to maintain normal airway responsiveness or tone. In the lung, distinct subsets of γδ T cell subsets seem to have specific roles, one subset promoting allergic inflammation, the other serving a protective role.",

keywords = "Airway hyper-responsiveness, Asthma, Lymphocytes, γδ T cells",

author = "Born, {Willi K.} and Michael Lahn and Katsuyuki Takeda and Arihiko Kanehiro and O'Brien, {Rebecca L.} and Gelfand, {Erwin W.}",

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year = "2000",

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doi = "10.1186/rr26",

language = "English",

volume = "1",

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AU - Born, Willi K.

AU - Lahn, Michael

AU - Takeda, Katsuyuki

AU - Kanehiro, Arihiko

AU - O'Brien, Rebecca L.

AU - Gelfand, Erwin W.

PY - 2000/11/7

Y1 - 2000/11/7

N2 - Since their discovery 15 years ago, the role of γδ T cells has remained somewhat elusive. Responses of γδ T cells have been found in numerous infectious and non-infectious diseases. New evidence points to γδ T cells' functioning in the airways to maintain normal airway responsiveness or tone. In the lung, distinct subsets of γδ T cell subsets seem to have specific roles, one subset promoting allergic inflammation, the other serving a protective role.

AB - Since their discovery 15 years ago, the role of γδ T cells has remained somewhat elusive. Responses of γδ T cells have been found in numerous infectious and non-infectious diseases. New evidence points to γδ T cells' functioning in the airways to maintain normal airway responsiveness or tone. In the lung, distinct subsets of γδ T cell subsets seem to have specific roles, one subset promoting allergic inflammation, the other serving a protective role.

KW - Airway hyper-responsiveness

KW - Asthma

KW - Lymphocytes

KW - γδ T cells

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JF - Respiratory Research

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ER -

Role of γδ T cells in protecting normal airway function

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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