Role of γδ T cells in protecting normal airway function

Willi K. Born, Michael Lahn, Katsuyuki Takeda, Arihiko Kanehiro, Rebecca L. O'Brien, Erwin W. Gelfand

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Since their discovery 15 years ago, the role of γδ T cells has remained somewhat elusive. Responses of γδ T cells have been found in numerous infectious and non-infectious diseases. New evidence points to γδ T cells' functioning in the airways to maintain normal airway responsiveness or tone. In the lung, distinct subsets of γδ T cell subsets seem to have specific roles, one subset promoting allergic inflammation, the other serving a protective role.

Original languageEnglish
Pages (from-to)151-158
Number of pages8
JournalRespiratory Research
Volume1
Issue number1
DOIs
Publication statusPublished - Nov 7 2000
Externally publishedYes

Fingerprint

T-Lymphocytes
T-Lymphocyte Subsets
Inflammation
Lung

Keywords

  • Airway hyper-responsiveness
  • Asthma
  • Lymphocytes
  • γδ T cells

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Medicine(all)

Cite this

Born, W. K., Lahn, M., Takeda, K., Kanehiro, A., O'Brien, R. L., & Gelfand, E. W. (2000). Role of γδ T cells in protecting normal airway function. Respiratory Research, 1(1), 151-158. https://doi.org/10.1186/rr26

Role of γδ T cells in protecting normal airway function. / Born, Willi K.; Lahn, Michael; Takeda, Katsuyuki; Kanehiro, Arihiko; O'Brien, Rebecca L.; Gelfand, Erwin W.

In: Respiratory Research, Vol. 1, No. 1, 07.11.2000, p. 151-158.

Research output: Contribution to journalArticle

Born, WK, Lahn, M, Takeda, K, Kanehiro, A, O'Brien, RL & Gelfand, EW 2000, 'Role of γδ T cells in protecting normal airway function', Respiratory Research, vol. 1, no. 1, pp. 151-158. https://doi.org/10.1186/rr26
Born WK, Lahn M, Takeda K, Kanehiro A, O'Brien RL, Gelfand EW. Role of γδ T cells in protecting normal airway function. Respiratory Research. 2000 Nov 7;1(1):151-158. https://doi.org/10.1186/rr26
Born, Willi K. ; Lahn, Michael ; Takeda, Katsuyuki ; Kanehiro, Arihiko ; O'Brien, Rebecca L. ; Gelfand, Erwin W. / Role of γδ T cells in protecting normal airway function. In: Respiratory Research. 2000 ; Vol. 1, No. 1. pp. 151-158.
@article{ad3875c62a004e98bfc06a3faee87b4e,
title = "Role of γδ T cells in protecting normal airway function",
abstract = "Since their discovery 15 years ago, the role of γδ T cells has remained somewhat elusive. Responses of γδ T cells have been found in numerous infectious and non-infectious diseases. New evidence points to γδ T cells' functioning in the airways to maintain normal airway responsiveness or tone. In the lung, distinct subsets of γδ T cell subsets seem to have specific roles, one subset promoting allergic inflammation, the other serving a protective role.",
keywords = "Airway hyper-responsiveness, Asthma, Lymphocytes, γδ T cells",
author = "Born, {Willi K.} and Michael Lahn and Katsuyuki Takeda and Arihiko Kanehiro and O'Brien, {Rebecca L.} and Gelfand, {Erwin W.}",
year = "2000",
month = "11",
day = "7",
doi = "10.1186/rr26",
language = "English",
volume = "1",
pages = "151--158",
journal = "Respiratory Research",
issn = "1465-9921",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Role of γδ T cells in protecting normal airway function

AU - Born, Willi K.

AU - Lahn, Michael

AU - Takeda, Katsuyuki

AU - Kanehiro, Arihiko

AU - O'Brien, Rebecca L.

AU - Gelfand, Erwin W.

PY - 2000/11/7

Y1 - 2000/11/7

N2 - Since their discovery 15 years ago, the role of γδ T cells has remained somewhat elusive. Responses of γδ T cells have been found in numerous infectious and non-infectious diseases. New evidence points to γδ T cells' functioning in the airways to maintain normal airway responsiveness or tone. In the lung, distinct subsets of γδ T cell subsets seem to have specific roles, one subset promoting allergic inflammation, the other serving a protective role.

AB - Since their discovery 15 years ago, the role of γδ T cells has remained somewhat elusive. Responses of γδ T cells have been found in numerous infectious and non-infectious diseases. New evidence points to γδ T cells' functioning in the airways to maintain normal airway responsiveness or tone. In the lung, distinct subsets of γδ T cell subsets seem to have specific roles, one subset promoting allergic inflammation, the other serving a protective role.

KW - Airway hyper-responsiveness

KW - Asthma

KW - Lymphocytes

KW - γδ T cells

UR - http://www.scopus.com/inward/record.url?scp=0000531617&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0000531617&partnerID=8YFLogxK

U2 - 10.1186/rr26

DO - 10.1186/rr26

M3 - Article

C2 - 11667979

AN - SCOPUS:0000531617

VL - 1

SP - 151

EP - 158

JO - Respiratory Research

JF - Respiratory Research

SN - 1465-9921

IS - 1

ER -