Role and Regulation of Myeloid Zinc Finger Protein 1 in Cancer

Taka Eguchi, Thomas Prince, Barbara Wegiel, Stuart K. Calderwood

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Myeloid zinc finger 1 (MZF1) belongs to the SCAN-Zinc Finger (SCAN-ZF) transcription factor family that has recently been implicated in a number of types of cancer. Although the initial studies concentrated on the role of MZF1 in myeloid differentiation and leukemia, the factor now appears to be involved in the etiology of major solid tumors such as lung, cervical, breast, and colorectal cancer. Here we discuss the regulation of MZF1 that mediated its recruitment and activation in cancer, concentrating on posttranslational modification by phosphorylation, and sumoylation, formation of promyelocytic leukemia nuclear bodies and its association with co-activators and co-repressors.

Original languageEnglish
Pages (from-to)2146-2154
Number of pages9
JournalJournal of Cellular Biochemistry
Volume116
Issue number10
DOIs
Publication statusPublished - Oct 1 2015

Keywords

  • CANCER
  • FINGER-1
  • INVASION
  • MYELOID
  • NUCLEAR BODY
  • SUMO
  • ZINC

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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