Rod visual pigment optimizes active state to achieve efficient g protein activation as compared with cone visual pigments

Keiichi Kojima, Yasushi Imamoto, Ryo Maeda, Takahiro Yamashita, Yoshinori Shichida

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: The relationship between the properties of visual pigment and photoreceptor amplification efficiency is controversial. Results: Rhodopsin activates G protein more efficiently than cone pigments. Conclusion: Visual pigment properties are directly related to the photoreceptor sensitivity diversification. Significance: Amplification of cell responses is regulated by receptor molecules.

Original languageEnglish
Pages (from-to)5061-5073
Number of pages13
JournalJournal of Biological Chemistry
Volume289
Issue number8
DOIs
Publication statusPublished - Feb 21 2014
Externally publishedYes

Fingerprint

Retinal Pigments
Amplification
Cones
Chemical activation
Rhodopsin
GTP-Binding Proteins
Pigments
Proteins
Molecules

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Rod visual pigment optimizes active state to achieve efficient g protein activation as compared with cone visual pigments. / Kojima, Keiichi; Imamoto, Yasushi; Maeda, Ryo; Yamashita, Takahiro; Shichida, Yoshinori.

In: Journal of Biological Chemistry, Vol. 289, No. 8, 21.02.2014, p. 5061-5073.

Research output: Contribution to journalArticle

Kojima, Keiichi ; Imamoto, Yasushi ; Maeda, Ryo ; Yamashita, Takahiro ; Shichida, Yoshinori. / Rod visual pigment optimizes active state to achieve efficient g protein activation as compared with cone visual pigments. In: Journal of Biological Chemistry. 2014 ; Vol. 289, No. 8. pp. 5061-5073.
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