Rod visual pigment optimizes active state to achieve efficient g protein activation as compared with cone visual pigments

Keiichi Kojima, Yasushi Imamoto, Ryo Maeda, Takahiro Yamashita, Yoshinori Shichida

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: The relationship between the properties of visual pigment and photoreceptor amplification efficiency is controversial. Results: Rhodopsin activates G protein more efficiently than cone pigments. Conclusion: Visual pigment properties are directly related to the photoreceptor sensitivity diversification. Significance: Amplification of cell responses is regulated by receptor molecules.

Original languageEnglish
Pages (from-to)5061-5073
Number of pages13
JournalJournal of Biological Chemistry
Volume289
Issue number8
DOIs
Publication statusPublished - Feb 21 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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