Rod visual pigment optimizes active state to achieve efficient g protein activation as compared with cone visual pigments

Keiichi Kojima; Yasushi Imamoto; Ryo Maeda; Takahiro Yamashita; Yoshinori Shichida

doi:10.1074/jbc.M113.508507

Rod visual pigment optimizes active state to achieve efficient g protein activation as compared with cone visual pigments

Keiichi Kojima, Yasushi Imamoto, Ryo Maeda, Takahiro Yamashita, Yoshinori Shichida

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Background: The relationship between the properties of visual pigment and photoreceptor amplification efficiency is controversial. Results: Rhodopsin activates G protein more efficiently than cone pigments. Conclusion: Visual pigment properties are directly related to the photoreceptor sensitivity diversification. Significance: Amplification of cell responses is regulated by receptor molecules.

Original language	English
Pages (from-to)	5061-5073
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	289
Issue number	8
DOIs	https://doi.org/10.1074/jbc.M113.508507
Publication status	Published - Feb 21 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "Rod visual pigment optimizes active state to achieve efficient g protein activation as compared with cone visual pigments",

abstract = "Background: The relationship between the properties of visual pigment and photoreceptor amplification efficiency is controversial. Results: Rhodopsin activates G protein more efficiently than cone pigments. Conclusion: Visual pigment properties are directly related to the photoreceptor sensitivity diversification. Significance: Amplification of cell responses is regulated by receptor molecules.",

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