TY - JOUR
T1 - Robot-assisted partial nephrectomy with minimum follow-up of 5 years
T2 - A multi-center prospective study in Japan
AU - Furukawa, Junya
AU - Hinata, Nobuyuki
AU - Teisima, Jun
AU - Takenaka, Atsushi
AU - Shiroki, Ryoichi
AU - Kobayashi, Yasuyuki
AU - Kanayama, Hiro omi
AU - Hattori, Kazunori
AU - Horie, Shigeo
AU - Tozawa, Keiichi
AU - Kato, Masashi
AU - Ohyama, Chikara
AU - Habuchi, Tomonori
AU - Kawamorita, Naoki
AU - Eto, Masatoshi
AU - Fujisawa, Masato
N1 - Funding Information:
The authors thank Dr Takashi Omori and Dr Akihide Konishi of the Clinical and Translational Research Center, Kobe University Hospital for providing statistical suggestion and study management. This study was funded by Intuitive Surgical Sari, France. The funder had no role in designing the study, managing and analyzing data, and writing the manuscript.
Publisher Copyright:
© 2022 The Japanese Urological Association.
PY - 2022
Y1 - 2022
N2 - Objectives: Robot-assisted partial nephrectomy is widely performed for small renal masses, achieving excellent perioperative and intermediate oncological outcomes. However, long-term oncological, functional, and quality of life outcomes after robot-assisted partial nephrectomy remain unclear. In this study, we aimed to evaluate quality of life at 1 year and oncological and functional outcomes of robot-assisted partial nephrectomy after a minimum follow-up of 5 years. Methods: Personal, perioperative, postoperative, functional, oncological, and quality of life data were evaluated. The EQ-5D-5L tool, which incorporates health profiles and a EuroQol Visual Analog Scale, was used to assess quality of life preoperatively and 365 days postoperatively. Regarding oncological and functional outcomes, overall survival, recurrence-free survival, and changes in estimated glomerular filtration rate were calculated. Results: There were few changes in levels between the two time points for all EQ-5D dimensions. The mean change in EQ-5D-5L was 0.020 (95% confidence interval 0.006–0.033, P = 0.006), and in EuroQol Visual Analog Scale score 4.60 (95% confidence interval 2.17–7.02, P = 0.0003). Overall and recurrence-free survival 5 years after robot-assisted partial nephrectomy were 97.9% and 92.8%, respectively. After an early postoperative decrease, the estimated glomerular filtration rate remained stable over time. Conclusions: Robot-assisted partial nephrectomy in patients with a T1 renal tumor is safe, feasible, and effective from the perspective of quality of life and survival, even after 5 years. When making treatment decisions, perioperative and quality of life outcomes should be considered together with long-term oncological outcomes.
AB - Objectives: Robot-assisted partial nephrectomy is widely performed for small renal masses, achieving excellent perioperative and intermediate oncological outcomes. However, long-term oncological, functional, and quality of life outcomes after robot-assisted partial nephrectomy remain unclear. In this study, we aimed to evaluate quality of life at 1 year and oncological and functional outcomes of robot-assisted partial nephrectomy after a minimum follow-up of 5 years. Methods: Personal, perioperative, postoperative, functional, oncological, and quality of life data were evaluated. The EQ-5D-5L tool, which incorporates health profiles and a EuroQol Visual Analog Scale, was used to assess quality of life preoperatively and 365 days postoperatively. Regarding oncological and functional outcomes, overall survival, recurrence-free survival, and changes in estimated glomerular filtration rate were calculated. Results: There were few changes in levels between the two time points for all EQ-5D dimensions. The mean change in EQ-5D-5L was 0.020 (95% confidence interval 0.006–0.033, P = 0.006), and in EuroQol Visual Analog Scale score 4.60 (95% confidence interval 2.17–7.02, P = 0.0003). Overall and recurrence-free survival 5 years after robot-assisted partial nephrectomy were 97.9% and 92.8%, respectively. After an early postoperative decrease, the estimated glomerular filtration rate remained stable over time. Conclusions: Robot-assisted partial nephrectomy in patients with a T1 renal tumor is safe, feasible, and effective from the perspective of quality of life and survival, even after 5 years. When making treatment decisions, perioperative and quality of life outcomes should be considered together with long-term oncological outcomes.
KW - partial nephrectomy
KW - prospective study
KW - quality of life
KW - renal cell carcinoma
KW - robot-assisted surgery
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U2 - 10.1111/iju.14960
DO - 10.1111/iju.14960
M3 - Article
AN - SCOPUS:85131889952
JO - International Journal of Urology
JF - International Journal of Urology
SN - 0919-8172
ER -