Rituximab Was Effective for Treatment of Anti- N -Methyl- d -Aspartate Receptor Encephalitis in Early Adolescence in Initially Suspected Dissociative Disorder

Takashi Shibata, Hiroki Kawai, Shinji Sakamoto, Ko Tsutsui, Takashi Kanbayashi, Keiko Tanaka, Manabu Takaki

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is an increasingly recognized etiology of psychiatric symptoms. Because patients with anti-NMDAR encephalitis frequently show aggression, mania, hallucination, depression, or delusion, they are initially diagnosed with schizophrenia or mood disorders. There is only 1 case report of an initially diagnosed dissociative disorder. Methods We obtained consent for the presentation and have not identified individuals for ethical reasons. Results We first report an adolescent female patient with anti-NMDAR encephalitis who was initially suspected of having dissociative disorder but was responsive to immunotherapies including rituximab. In this case, her symptoms and electroencephalogram findings were proportional to the antibody titer in the cerebrospinal fluid. Conclusions It is important to consider the possibility of autoimmune encephalitis and immunotherapy including rituximab in cases of not only acute psychosis but also dissociation.

Original languageEnglish
Pages (from-to)99-100
Number of pages2
JournalClinical Neuropharmacology
Volume44
Issue number3
DOIs
Publication statusPublished - 2021

Keywords

  • anti-NMDAR encephalitis
  • antibody titer
  • dissociative disorder
  • early adolescence
  • rituximab

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Neurology
  • Pharmacology (medical)

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