Risk stratification in patients with brugada syndrome without previous cardiac arrest – Prognostic value of combined risk factors

Hideo Okamura, Tsukasa Kamakura, Hiroshi Morita, Koji Tokioka, Ikutaro Nakajima, Mitsuru Wada, Kohei Ishibashi, Koji Miyamoto, Takashi Noda, Takeshi Aiba, Nobuhiro Nishii, Satoshi Nagase, Wataru Shimizu, Satoshi Yasuda, Hisao Ogawa, Shiro Kamakura, Hiroshi Itoh, Tohru Ohe, Kengo F. Kusano

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background: Risk stratification in patients with Brugada syndrome for primary prevention of sudden cardiac death is still an unsettled issue. A recent consensus statement suggested the indication of implantable cardioverter defibrillator (ICD) depending on the clinical risk factors present (spontaneous type 1 Brugada electrocardiogram (ECG) [Sp1], history of syncope [syncope], and ventricular fibrillation during programmed electrical stimulation [PES+]). The indication of ICD for the majority of patients, however, remains unclear. Methods and Results: A total of 218 consecutive patients (211 male; aged 46±13 years) with a type 1 Brugada ECG without a history of cardiac arrest who underwent evaluation for ICD including electrophysiological testing were examined retrospectively. During a mean follow-up period of 78 months, 26 patients (12%) developed arrhythmic events. On Kaplan-Meier analysis patients with each of Sp1, syncope, or PES+ suffered arrhythmic events more frequently (P=0.018, P

Original languageEnglish
Pages (from-to)310-317
Number of pages8
JournalCirculation Journal
Volume79
Issue number2
DOIs
Publication statusPublished - Jan 16 2015

Fingerprint

Brugada Syndrome
Heart Arrest
Implantable Defibrillators
Syncope
Electrocardiography
Sudden Cardiac Death
Kaplan-Meier Estimate
Ventricular Fibrillation
Primary Prevention
Electric Stimulation

Keywords

  • Brugada syndrome
  • Electrophysiological study
  • Primary prevention
  • Risk stratification
  • Syncope

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Risk stratification in patients with brugada syndrome without previous cardiac arrest – Prognostic value of combined risk factors. / Okamura, Hideo; Kamakura, Tsukasa; Morita, Hiroshi; Tokioka, Koji; Nakajima, Ikutaro; Wada, Mitsuru; Ishibashi, Kohei; Miyamoto, Koji; Noda, Takashi; Aiba, Takeshi; Nishii, Nobuhiro; Nagase, Satoshi; Shimizu, Wataru; Yasuda, Satoshi; Ogawa, Hisao; Kamakura, Shiro; Itoh, Hiroshi; Ohe, Tohru; Kusano, Kengo F.

In: Circulation Journal, Vol. 79, No. 2, 16.01.2015, p. 310-317.

Research output: Contribution to journalArticle

Okamura, H, Kamakura, T, Morita, H, Tokioka, K, Nakajima, I, Wada, M, Ishibashi, K, Miyamoto, K, Noda, T, Aiba, T, Nishii, N, Nagase, S, Shimizu, W, Yasuda, S, Ogawa, H, Kamakura, S, Itoh, H, Ohe, T & Kusano, KF 2015, 'Risk stratification in patients with brugada syndrome without previous cardiac arrest – Prognostic value of combined risk factors', Circulation Journal, vol. 79, no. 2, pp. 310-317. https://doi.org/10.1253/circj.CJ-14-1059
Okamura, Hideo ; Kamakura, Tsukasa ; Morita, Hiroshi ; Tokioka, Koji ; Nakajima, Ikutaro ; Wada, Mitsuru ; Ishibashi, Kohei ; Miyamoto, Koji ; Noda, Takashi ; Aiba, Takeshi ; Nishii, Nobuhiro ; Nagase, Satoshi ; Shimizu, Wataru ; Yasuda, Satoshi ; Ogawa, Hisao ; Kamakura, Shiro ; Itoh, Hiroshi ; Ohe, Tohru ; Kusano, Kengo F. / Risk stratification in patients with brugada syndrome without previous cardiac arrest – Prognostic value of combined risk factors. In: Circulation Journal. 2015 ; Vol. 79, No. 2. pp. 310-317.
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