Risk Factors for the Development of Desmoid Tumor After Colectomy in Patients with Familial Adenomatous Polyposis: Multicenter Retrospective Cohort Study in Japan

Yasufumi Saito, Takao Hinoi, Hideki Ueno, Hirotoshi Kobayashi, Tsuyoshi Konishi, Fumio Ishida, Tatsuro Yamaguchi, Yasuhiro Inoue, Yukihide Kanemitsu, Naohiro Tomita, Nagahide Matsubara, Koji Komori, Kenjiro Kotake, Takeshi Nagasaka, Hirotoshi Hasegawa, Motoi Koyama, Hideki Ohdan, Toshiaki Watanabe, Kenichi Sugihara, Hideyuki Ishida

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Desmoid tumor (DT) is the primary cause of death in patients with familial adenomatous polyposis (FAP) after restorative proctocolectomy. This study aimed to identify risk factors for DT in a Japanese population. Methods: Clinical data for 319 patients with FAP undergoing first colectomy from 2000 to 2012 were reviewed retrospectively. Results: Two hundred seventy-seven FAP patients were included in this study. Thirty-nine (14.1 %) patients developed DT. Occurrence sites were the intraperitoneal region in 25 (64.1 %) cases, intraperitoneal region and abdominal wall in three (7.7 %), and abdominal wall in nine (23.1 %). The mean period from surgery to DT development was 26.3 months (range 4–120 months). Gender (female vs. male, p = 0.03), age at surgery (>30 vs. ≤30 years, p = 0.02), purpose of surgery (prophylactic vs. cancer excision, p = 0.01), and surgical procedure (proctocolectomy [ileoanal anastomosis (IAA), ileoanal canal anastomosis (IACA), total proctocolectomy (TPC)] vs. total colectomy [ileorectal anastomosis, partial colectomy]; p = 0.03) significantly influenced the estimated cumulative risk of developing DT at 5 years after surgery. Conversely, approach (laparoscopic vs. open, p = 0.17) had no significant effect on the increased risk of DT occurrence. In multivariate analysis, female gender, with a hazard ratio of 2.2 (p = 0.02,) and proctocolectomy (IAA, IACA, TPC), with a hazard ratio of 2.2 (p = 0.03), were independent risk factors for DT incidence after colectomy. Conclusions: Female gender and proctocolectomy (IAA, IACA, TPC) were independent risk factors for developing DT after colectomy in patients with FAP.

Original languageEnglish
Pages (from-to)559-565
Number of pages7
JournalAnnals of Surgical Oncology
Volume23
DOIs
Publication statusPublished - Aug 1 2016

ASJC Scopus subject areas

  • Surgery
  • Oncology

Fingerprint Dive into the research topics of 'Risk Factors for the Development of Desmoid Tumor After Colectomy in Patients with Familial Adenomatous Polyposis: Multicenter Retrospective Cohort Study in Japan'. Together they form a unique fingerprint.

  • Cite this

    Saito, Y., Hinoi, T., Ueno, H., Kobayashi, H., Konishi, T., Ishida, F., Yamaguchi, T., Inoue, Y., Kanemitsu, Y., Tomita, N., Matsubara, N., Komori, K., Kotake, K., Nagasaka, T., Hasegawa, H., Koyama, M., Ohdan, H., Watanabe, T., Sugihara, K., & Ishida, H. (2016). Risk Factors for the Development of Desmoid Tumor After Colectomy in Patients with Familial Adenomatous Polyposis: Multicenter Retrospective Cohort Study in Japan. Annals of Surgical Oncology, 23, 559-565. https://doi.org/10.1245/s10434-016-5380-3