Risk Factors for the Development of Desmoid Tumor After Colectomy in Patients with Familial Adenomatous Polyposis: Multicenter Retrospective Cohort Study in Japan

Yasufumi Saito, Takao Hinoi, Hideki Ueno, Hirotoshi Kobayashi, Tsuyoshi Konishi, Fumio Ishida, Tatsuro Yamaguchi, Yasuhiro Inoue, Yukihide Kanemitsu, Naohiro Tomita, Nagahide Matsubara, Koji Komori, Kenjiro Kotake, Takeshi Nagasaka, Hirotoshi Hasegawa, Motoi Koyama, Hideki Ohdan, Toshiaki Watanabe, Kenichi Sugihara, Hideyuki Ishida

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Abstract

Background: Desmoid tumor (DT) is the primary cause of death in patients with familial adenomatous polyposis (FAP) after restorative proctocolectomy. This study aimed to identify risk factors for DT in a Japanese population. Methods: Clinical data for 319 patients with FAP undergoing first colectomy from 2000 to 2012 were reviewed retrospectively. Results: Two hundred seventy-seven FAP patients were included in this study. Thirty-nine (14.1 %) patients developed DT. Occurrence sites were the intraperitoneal region in 25 (64.1 %) cases, intraperitoneal region and abdominal wall in three (7.7 %), and abdominal wall in nine (23.1 %). The mean period from surgery to DT development was 26.3 months (range 4–120 months). Gender (female vs. male, p = 0.03), age at surgery (>30 vs. ≤30 years, p = 0.02), purpose of surgery (prophylactic vs. cancer excision, p = 0.01), and surgical procedure (proctocolectomy [ileoanal anastomosis (IAA), ileoanal canal anastomosis (IACA), total proctocolectomy (TPC)] vs. total colectomy [ileorectal anastomosis, partial colectomy]; p = 0.03) significantly influenced the estimated cumulative risk of developing DT at 5 years after surgery. Conversely, approach (laparoscopic vs. open, p = 0.17) had no significant effect on the increased risk of DT occurrence. In multivariate analysis, female gender, with a hazard ratio of 2.2 (p = 0.02,) and proctocolectomy (IAA, IACA, TPC), with a hazard ratio of 2.2 (p = 0.03), were independent risk factors for DT incidence after colectomy. Conclusions: Female gender and proctocolectomy (IAA, IACA, TPC) were independent risk factors for developing DT after colectomy in patients with FAP.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalAnnals of Surgical Oncology
DOIs
Publication statusAccepted/In press - Jul 7 2016

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Aggressive Fibromatosis
Adenomatous Polyposis Coli
Colectomy
Japan
Cohort Studies
Retrospective Studies
Neoplasms
Abdominal Wall
Restorative Proctocolectomy
Cause of Death
Multivariate Analysis

ASJC Scopus subject areas

  • Surgery
  • Oncology

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Risk Factors for the Development of Desmoid Tumor After Colectomy in Patients with Familial Adenomatous Polyposis : Multicenter Retrospective Cohort Study in Japan. / Saito, Yasufumi; Hinoi, Takao; Ueno, Hideki; Kobayashi, Hirotoshi; Konishi, Tsuyoshi; Ishida, Fumio; Yamaguchi, Tatsuro; Inoue, Yasuhiro; Kanemitsu, Yukihide; Tomita, Naohiro; Matsubara, Nagahide; Komori, Koji; Kotake, Kenjiro; Nagasaka, Takeshi; Hasegawa, Hirotoshi; Koyama, Motoi; Ohdan, Hideki; Watanabe, Toshiaki; Sugihara, Kenichi; Ishida, Hideyuki.

In: Annals of Surgical Oncology, 07.07.2016, p. 1-7.

Research output: Contribution to journalArticle

Saito, Y, Hinoi, T, Ueno, H, Kobayashi, H, Konishi, T, Ishida, F, Yamaguchi, T, Inoue, Y, Kanemitsu, Y, Tomita, N, Matsubara, N, Komori, K, Kotake, K, Nagasaka, T, Hasegawa, H, Koyama, M, Ohdan, H, Watanabe, T, Sugihara, K & Ishida, H 2016, 'Risk Factors for the Development of Desmoid Tumor After Colectomy in Patients with Familial Adenomatous Polyposis: Multicenter Retrospective Cohort Study in Japan', Annals of Surgical Oncology, pp. 1-7. https://doi.org/10.1245/s10434-016-5380-3
Saito, Yasufumi ; Hinoi, Takao ; Ueno, Hideki ; Kobayashi, Hirotoshi ; Konishi, Tsuyoshi ; Ishida, Fumio ; Yamaguchi, Tatsuro ; Inoue, Yasuhiro ; Kanemitsu, Yukihide ; Tomita, Naohiro ; Matsubara, Nagahide ; Komori, Koji ; Kotake, Kenjiro ; Nagasaka, Takeshi ; Hasegawa, Hirotoshi ; Koyama, Motoi ; Ohdan, Hideki ; Watanabe, Toshiaki ; Sugihara, Kenichi ; Ishida, Hideyuki. / Risk Factors for the Development of Desmoid Tumor After Colectomy in Patients with Familial Adenomatous Polyposis : Multicenter Retrospective Cohort Study in Japan. In: Annals of Surgical Oncology. 2016 ; pp. 1-7.
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abstract = "Background: Desmoid tumor (DT) is the primary cause of death in patients with familial adenomatous polyposis (FAP) after restorative proctocolectomy. This study aimed to identify risk factors for DT in a Japanese population. Methods: Clinical data for 319 patients with FAP undergoing first colectomy from 2000 to 2012 were reviewed retrospectively. Results: Two hundred seventy-seven FAP patients were included in this study. Thirty-nine (14.1 {\%}) patients developed DT. Occurrence sites were the intraperitoneal region in 25 (64.1 {\%}) cases, intraperitoneal region and abdominal wall in three (7.7 {\%}), and abdominal wall in nine (23.1 {\%}). The mean period from surgery to DT development was 26.3 months (range 4–120 months). Gender (female vs. male, p = 0.03), age at surgery (>30 vs. ≤30 years, p = 0.02), purpose of surgery (prophylactic vs. cancer excision, p = 0.01), and surgical procedure (proctocolectomy [ileoanal anastomosis (IAA), ileoanal canal anastomosis (IACA), total proctocolectomy (TPC)] vs. total colectomy [ileorectal anastomosis, partial colectomy]; p = 0.03) significantly influenced the estimated cumulative risk of developing DT at 5 years after surgery. Conversely, approach (laparoscopic vs. open, p = 0.17) had no significant effect on the increased risk of DT occurrence. In multivariate analysis, female gender, with a hazard ratio of 2.2 (p = 0.02,) and proctocolectomy (IAA, IACA, TPC), with a hazard ratio of 2.2 (p = 0.03), were independent risk factors for DT incidence after colectomy. Conclusions: Female gender and proctocolectomy (IAA, IACA, TPC) were independent risk factors for developing DT after colectomy in patients with FAP.",
author = "Yasufumi Saito and Takao Hinoi and Hideki Ueno and Hirotoshi Kobayashi and Tsuyoshi Konishi and Fumio Ishida and Tatsuro Yamaguchi and Yasuhiro Inoue and Yukihide Kanemitsu and Naohiro Tomita and Nagahide Matsubara and Koji Komori and Kenjiro Kotake and Takeshi Nagasaka and Hirotoshi Hasegawa and Motoi Koyama and Hideki Ohdan and Toshiaki Watanabe and Kenichi Sugihara and Hideyuki Ishida",
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T1 - Risk Factors for the Development of Desmoid Tumor After Colectomy in Patients with Familial Adenomatous Polyposis

T2 - Multicenter Retrospective Cohort Study in Japan

AU - Saito, Yasufumi

AU - Hinoi, Takao

AU - Ueno, Hideki

AU - Kobayashi, Hirotoshi

AU - Konishi, Tsuyoshi

AU - Ishida, Fumio

AU - Yamaguchi, Tatsuro

AU - Inoue, Yasuhiro

AU - Kanemitsu, Yukihide

AU - Tomita, Naohiro

AU - Matsubara, Nagahide

AU - Komori, Koji

AU - Kotake, Kenjiro

AU - Nagasaka, Takeshi

AU - Hasegawa, Hirotoshi

AU - Koyama, Motoi

AU - Ohdan, Hideki

AU - Watanabe, Toshiaki

AU - Sugihara, Kenichi

AU - Ishida, Hideyuki

PY - 2016/7/7

Y1 - 2016/7/7

N2 - Background: Desmoid tumor (DT) is the primary cause of death in patients with familial adenomatous polyposis (FAP) after restorative proctocolectomy. This study aimed to identify risk factors for DT in a Japanese population. Methods: Clinical data for 319 patients with FAP undergoing first colectomy from 2000 to 2012 were reviewed retrospectively. Results: Two hundred seventy-seven FAP patients were included in this study. Thirty-nine (14.1 %) patients developed DT. Occurrence sites were the intraperitoneal region in 25 (64.1 %) cases, intraperitoneal region and abdominal wall in three (7.7 %), and abdominal wall in nine (23.1 %). The mean period from surgery to DT development was 26.3 months (range 4–120 months). Gender (female vs. male, p = 0.03), age at surgery (>30 vs. ≤30 years, p = 0.02), purpose of surgery (prophylactic vs. cancer excision, p = 0.01), and surgical procedure (proctocolectomy [ileoanal anastomosis (IAA), ileoanal canal anastomosis (IACA), total proctocolectomy (TPC)] vs. total colectomy [ileorectal anastomosis, partial colectomy]; p = 0.03) significantly influenced the estimated cumulative risk of developing DT at 5 years after surgery. Conversely, approach (laparoscopic vs. open, p = 0.17) had no significant effect on the increased risk of DT occurrence. In multivariate analysis, female gender, with a hazard ratio of 2.2 (p = 0.02,) and proctocolectomy (IAA, IACA, TPC), with a hazard ratio of 2.2 (p = 0.03), were independent risk factors for DT incidence after colectomy. Conclusions: Female gender and proctocolectomy (IAA, IACA, TPC) were independent risk factors for developing DT after colectomy in patients with FAP.

AB - Background: Desmoid tumor (DT) is the primary cause of death in patients with familial adenomatous polyposis (FAP) after restorative proctocolectomy. This study aimed to identify risk factors for DT in a Japanese population. Methods: Clinical data for 319 patients with FAP undergoing first colectomy from 2000 to 2012 were reviewed retrospectively. Results: Two hundred seventy-seven FAP patients were included in this study. Thirty-nine (14.1 %) patients developed DT. Occurrence sites were the intraperitoneal region in 25 (64.1 %) cases, intraperitoneal region and abdominal wall in three (7.7 %), and abdominal wall in nine (23.1 %). The mean period from surgery to DT development was 26.3 months (range 4–120 months). Gender (female vs. male, p = 0.03), age at surgery (>30 vs. ≤30 years, p = 0.02), purpose of surgery (prophylactic vs. cancer excision, p = 0.01), and surgical procedure (proctocolectomy [ileoanal anastomosis (IAA), ileoanal canal anastomosis (IACA), total proctocolectomy (TPC)] vs. total colectomy [ileorectal anastomosis, partial colectomy]; p = 0.03) significantly influenced the estimated cumulative risk of developing DT at 5 years after surgery. Conversely, approach (laparoscopic vs. open, p = 0.17) had no significant effect on the increased risk of DT occurrence. In multivariate analysis, female gender, with a hazard ratio of 2.2 (p = 0.02,) and proctocolectomy (IAA, IACA, TPC), with a hazard ratio of 2.2 (p = 0.03), were independent risk factors for DT incidence after colectomy. Conclusions: Female gender and proctocolectomy (IAA, IACA, TPC) were independent risk factors for developing DT after colectomy in patients with FAP.

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