Risk Factors for Systemic Air Embolism as a Complication of Percutaneous CT-guided Lung Biopsy: Multicenter Case-control Study

Hiroaki Ishii, Takao Hiraki, Hideo Gobara, Hiroyasu Fujiwara, Hidefumi Mimura, Kotaro Yasui, Tetsuya Doke, Takashi Mukai, Hironori Kurokawa, Yoshitomo Ando, Soichiro Hase, Toshihiro Iguchi, Takayuki Yabuki, Kenichi Omae, Nobuhisa Tajiri, Toshiharu Mitsuhashi, Susumu Kanazawa

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Purpose: To determine risk factors for systemic air embolism by percutaneous computed tomography (CT)-guided lung biopsy.

Methods: This case-control study used data from 2216 percutaneous lung biopsy procedures performed over 11 years at 12 institutions in Japan. Systemic air embolism was identified by retrospective review of CT images obtained during and immediately after the procedures. To fulfill our objective, multiple variables were compared between cases and controls with univariate analyses by using Student’s t test and Fisher’s exact test for numerical and categorical values, respectively. Multivariate logistic regression analysis was then performed using selected variables.

Results: Ten cases of systemic air embolism and 2,206 controls were identified. Univariate analyses showed that the lesions in the lower lobe (P = 0.025) and occurrence of parenchymal hemorrhage (P = 0.019) were significant risk factors. Multivariate analysis showed that the use of a larger biopsy needle was a significant risk factor (P = 0.014).

Conclusion: Parenchymal hemorrhage during the procedure, lesions in the lower lobe, and the use of larger biopsy needles may be risk factors for systemic air embolism by percutaneous CT-guided lung biopsy. Our findings may provide clues toward minimizing the risk of this complication.

Original languageEnglish
Pages (from-to)1312-1320
Number of pages9
JournalCardiovascular and Interventional Radiology
Volume37
Issue number5
DOIs
Publication statusPublished - Jan 1 2014

Keywords

  • Air embolism
  • CT-guided biopsy
  • Complication
  • Lung
  • Percutaneous

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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