Risk factors for nosocomial infection in the neonatal intensive care unit by the Japanese Nosocomial Infection Surveillance (JANIS)

Akira Babazono, Hiroyuki Kitajima, Shigeru Nishimaki, Tomohiko Nakamura, Seigo Shiga, Masahiro Hayakawa, Tahei Tanaka, Kazuo Sato, Hideki Nakayama, Satoshi Ibara, Hiroshi Une, Hiroyuki Doi

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

We evaluated the infection risks in the neonatal intensive care unit (NICU) using data of NICU infection surveillance data. The subjects were 871 NICU babies, consisting of 465 boys and 406 girls, who were cared for between June 2002 and January 2003 in 7 medical institutions that employed NICU infection surveillance. Infections were defined according to the National Nosocomial Infection Surveillance (NNIS) System. Of the 58 babies with nosocomial infections, 15 had methicillin-resistant Staphylococcus aureus (MRSA) infection. Multiple logistic regression analysis demonstrated that the odds ratio for nosocomial infections was significantly related to gender, birth weight and the insertion of a central venous catheter (CVC). When the birth weight group of more than 1, 500 g was regarded as the reference, the odds ratio was 2.35 in the birth weight group of 1,000-1,499 g and 8.82 in the birth weight group of less than 1,000 g. The odds ratio of the CVC (+) for nosocomial infection was 2.27. However, other devices including artificial ventilation, umbilical artery catheter, umbilical venous catheter, and urinary catheter were not significant risk factors. The incidence of MRSA infection rapidly increased from 0.3% in the birth weight group of more than 1,500 g to 2.1% in the birth weight group of 1,000-1,499 g, and to 11.1% in the birth weight group of less than 1,000 g. When the birth weight group of more than 1,500 g was regarded as the reference, multiple logistic regression analysis demonstrated that the odds ratio was 7.25 in the birth weight group of 1,000-1,499 g and 42.88 in the birth weight group of less than 1,000 g. These odds ratios were significantly higher than that in the reference group. However, the application of devices did not cause any significant differences in the odds ratio for MRSA infection. Copyright

Original languageEnglish
Article number6
JournalActa Medica Okayama
Volume62
Issue number4
Publication statusPublished - Aug 2008

Fingerprint

Intensive care units
Catheters
Neonatal Intensive Care Units
Cross Infection
Birth Weight
Methicillin
Odds Ratio
Regression analysis
Infection
Logistics
Methicillin-Resistant Staphylococcus aureus
Central Venous Catheters
Logistic Models
Regression Analysis
Umbilicus
Equipment and Supplies
Urinary Catheters
Umbilical Arteries

Keywords

  • JANIS
  • Neonatal intensive care unit
  • Nosocomial infection
  • Risk factors

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Risk factors for nosocomial infection in the neonatal intensive care unit by the Japanese Nosocomial Infection Surveillance (JANIS). / Babazono, Akira; Kitajima, Hiroyuki; Nishimaki, Shigeru; Nakamura, Tomohiko; Shiga, Seigo; Hayakawa, Masahiro; Tanaka, Tahei; Sato, Kazuo; Nakayama, Hideki; Ibara, Satoshi; Une, Hiroshi; Doi, Hiroyuki.

In: Acta Medica Okayama, Vol. 62, No. 4, 6, 08.2008.

Research output: Contribution to journalArticle

Babazono, A, Kitajima, H, Nishimaki, S, Nakamura, T, Shiga, S, Hayakawa, M, Tanaka, T, Sato, K, Nakayama, H, Ibara, S, Une, H & Doi, H 2008, 'Risk factors for nosocomial infection in the neonatal intensive care unit by the Japanese Nosocomial Infection Surveillance (JANIS)', Acta Medica Okayama, vol. 62, no. 4, 6.
Babazono, Akira ; Kitajima, Hiroyuki ; Nishimaki, Shigeru ; Nakamura, Tomohiko ; Shiga, Seigo ; Hayakawa, Masahiro ; Tanaka, Tahei ; Sato, Kazuo ; Nakayama, Hideki ; Ibara, Satoshi ; Une, Hiroshi ; Doi, Hiroyuki. / Risk factors for nosocomial infection in the neonatal intensive care unit by the Japanese Nosocomial Infection Surveillance (JANIS). In: Acta Medica Okayama. 2008 ; Vol. 62, No. 4.
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