Risk factors for increased left ventricular hypertrophy in patients with chronic kidney disease

Kosaku Nitta, Satoshi Iimuro, Enyu Imai, Seiichi Matsuo, Hirofumi Makino, Tadao Akizawa, Tsuyoshi Watanabe, Yasuo Ohashi, Akira Hishida

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Although left ventricular hypertrophy (LVH) has been established as a predictor of cardiovascular events in chronic kidney disease (CKD), the relationship between the prevalence of LVH and CKD stage during the predialysis period has not been fully examined. Methods: We measured left ventricular mass index (LVMI) in a cross-sectional cohort of participants in the Chronic Kidney Disease Japan Cohort (CKD-JAC) study in order to identify factors that are associated with increased LVMI in patients with stage 3-5 CKD. LVH was defined as LVMI > 125 g/m2 in male patients and >110 g/m2 in female patients. Results: We analyzed baseline characteristics in 1185 participants (male 63.7 %, female 36.3 %). Diabetes mellitus was the underlying disease in 41.3 % of patients, and mean age was 61.8 ± 11.1 years. LVH was detected in 21.7 % of patients at baseline. By multivariate logistic analysis, independent risk factors for LVH were past history of cardiovascular disease (odds ratio [OR] 0.574; 95 % confidence interval [CI] 0.360-0.916; P = 0.020), systolic blood pressure (OR 1.179; 95 % CI 1.021-1.360; P = 0.025), body mass index (OR 1.135; 95 % CI 1.074-1.200; P < 0.001), and serum calcium level (OR 0.589; 95 % CI 0.396-0.876; P = 0.009). Conclusion: Cross-sectional baseline data from the CKD-JAC study shed light on the association between LVH and risk factors in patients with decreased renal function. Further longitudinal analyses of the CKD-JAC cohort are needed to evaluate the prognostic value of LVH in CKD patients.

Original languageEnglish
Pages (from-to)730-742
Number of pages13
JournalClinical and Experimental Nephrology
Volume17
Issue number5
DOIs
Publication statusPublished - Oct 2013

Keywords

  • Albuminuria
  • Antihypertensive agent
  • Body mass index
  • Chronic kidney disease
  • Hypertension
  • Left ventricular hypertrophy
  • Mineral metabolism

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)

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  • Cite this

    Nitta, K., Iimuro, S., Imai, E., Matsuo, S., Makino, H., Akizawa, T., Watanabe, T., Ohashi, Y., & Hishida, A. (2013). Risk factors for increased left ventricular hypertrophy in patients with chronic kidney disease. Clinical and Experimental Nephrology, 17(5), 730-742. https://doi.org/10.1007/s10157-012-0758-4