Risk factors for fecal carriage of IMP-6-producing Enterobacteriaceae at a long-term care hospital in Japan: A follow-up report from the northern Osaka multicentre study group

Hideharu Hagiya, Norihisa Yamamoto, Ryuji Kawahara, Yukihiro Akeda, Rathina Kumar Shanmugakani, Akiko Ueda, Isao Nishi, Rumiko Asada, Hisao Yoshida, Kazunori Tomono

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The prevalence of carbapenem-resistant Enterobacteriaceae (CRE) has been increasing at medical institutions in Japan without even noticing. Recently, we performed a point prevalence survey for CRE carriage at a medical facility in northern Osaka that demonstrated an unexpectedly high prevalence of blaIMP-6-positive CRE, particularly at long-term care hospitals (LTCH). To identify the risk factors for CRE carriage, we collected clinical data of patients at a representative LTCH. Of 140 patients who were included in this study, 27 (19.3%) were colonized with metallo-beta-lactamase (IMP-6) producers. Pulsed-field gel electrophoresis of the IMP-6 producing Enterobacteriaceae suggested a non-clonal transmission of Escherichia coli, while a clonal spread was shown for Klebsiella pneumoniae. Risk factors for CRE colonization were a longer stay at the hospital stay and a lower independence state, as measured by Norton scales. We propose that a paradigm shift in infection control, inciting a coordinated regional effort to involve LTCHs, should be discussed in the aging society of Japan.

Original languageEnglish
Pages (from-to)769-772
Number of pages4
JournalJournal of Infection and Chemotherapy
Volume24
Issue number9
DOIs
Publication statusPublished - Sep 2018
Externally publishedYes

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Keywords

  • Aging society
  • Antimicrobial resistance
  • Carbapenem-resistant Enterobacteriaceae
  • Carbapenemase-producing Enterobacteriaceae
  • Metallo-beta-lactamase

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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