TY - JOUR
T1 - Risk factors for cytomegalovirus infection in patients with antineutrophil cytoplasmic antibody-associated vasculitis
AU - Morishita, Michiko
AU - Sada, Kenei
AU - Matsumoto, Yoshinori
AU - Hayashi, Keigo
AU - Asano, Yosuke
AU - Asano, Sumie Hiramatsu
AU - Ohashi, Keiji
AU - Miyawaki, Yoshia
AU - Katsuyama, Eri
AU - Watanabe, Haruki
AU - Kawabata, Tomoko
AU - Wada, Jun
N1 - Publisher Copyright:
© 2019 Morishita et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Aims Cytomegalovirus (CMV) infection under immunosuppression sometimes causes death. This study aimed to elucidate risk factors for CMV infection in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). Methods Patients with AAV who underwent remission induction treatment at Okayama University Hospital between 2006 and 2016 were retrospectively analyzed. The primary outcome was the development of CMV infection within 3 months. Results Of the 111 patients, 13 (11.7%) patients developed CMV infection. Patients with CMV infection were older (p = 0.030) and had a higher body mass index (p = 0.029) in comparison to those without CMV infection. A higher proportion had a severe form (p = 0.001) and granulomatosis with polyangiitis (GPA) (p = 0.001), as well as a higher Birmingham Vasculitis Activity Score (p = 0.018) and C-reactive protein (p = 0.018) levels at baseline. Using logistic regression analysis, severe form and GPA were independent risk factors (odds ratio [OR] = 9.68, 95% confidence interval [CI] = 1.92–60.23, and OR = 7.46, 95% CI = 1.46–47.60, respectively). In addition, patients with CMV infection were more likely than those without infection to be glucocorticoid-related diabetes mellitus (p = 0.025). Conclusion Our study highlights disease severity and subgroups of AAV as risk factors for CMV infection.
AB - Aims Cytomegalovirus (CMV) infection under immunosuppression sometimes causes death. This study aimed to elucidate risk factors for CMV infection in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). Methods Patients with AAV who underwent remission induction treatment at Okayama University Hospital between 2006 and 2016 were retrospectively analyzed. The primary outcome was the development of CMV infection within 3 months. Results Of the 111 patients, 13 (11.7%) patients developed CMV infection. Patients with CMV infection were older (p = 0.030) and had a higher body mass index (p = 0.029) in comparison to those without CMV infection. A higher proportion had a severe form (p = 0.001) and granulomatosis with polyangiitis (GPA) (p = 0.001), as well as a higher Birmingham Vasculitis Activity Score (p = 0.018) and C-reactive protein (p = 0.018) levels at baseline. Using logistic regression analysis, severe form and GPA were independent risk factors (odds ratio [OR] = 9.68, 95% confidence interval [CI] = 1.92–60.23, and OR = 7.46, 95% CI = 1.46–47.60, respectively). In addition, patients with CMV infection were more likely than those without infection to be glucocorticoid-related diabetes mellitus (p = 0.025). Conclusion Our study highlights disease severity and subgroups of AAV as risk factors for CMV infection.
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U2 - 10.1371/journal.pone.0218705
DO - 10.1371/journal.pone.0218705
M3 - Article
C2 - 31291263
AN - SCOPUS:85069546896
SN - 1932-6203
VL - 14
JO - PLoS One
JF - PLoS One
IS - 7
M1 - e0218705
ER -
