TY - JOUR
T1 - Risk factors for chronic damage accumulation across different onset eras in systemic lupus erythematosus
T2 - A cross-sectional analysis of a lupus registry of nationwide institutions (LUNA)
AU - Ohashi, Keiji
AU - Sada, Kenei
AU - Asano, Yosuke
AU - Hayashi, Keigo
AU - Yamamura, Yuriko
AU - Asano, Sumie Hiramatsu
AU - Miyawaki, Yoshia
AU - Morishita, Michiko
AU - Katsuyama, Eri
AU - Watanabe, Haruki
AU - Tatebe, Noriko
AU - Narazaki, Mariko
AU - Matsumoto, Yoshinori
AU - Sunahori-Watanabe, Katsue
AU - Kawabata, Tomoko
AU - Yajima, Nobuyuki
AU - Wada, Jun
N1 - Publisher Copyright:
© 2020 by Okayama University Medical School.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020
Y1 - 2020
N2 - Chronic damage accumulation affects not only mortality but also quality of life in patients with systemic lupus erythematosus (SLE). Risk factors for chronic damage were explored in SLE through different onset eras. Two hundred forty-five patients at Okayama University Hospital and Showa University Hospital were divided into three groups based on the onset era: a past-onset group (onset before 1995; n=83), middle-onset group (1996-2009; n=88), and recent-onset group (after 2010; n=74). The mean Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) score as an index of chronic damage was 1.93, 1.24, and 0.53 in the past-, middle-, and recent-onset groups, respectively. In the pastonset group, the total SDI score was significantly associated with glucocorticoid monotherapy by linear regression analysis (β-coefficient [β]=0.63; 95% confidence interval [CI], 0.21-1.05) and C-reactive protein levels (β=0.67; 95% CI, 0.27-1.07). In the middle-onset group, the total SDI score was significantly associated with the SLE Disease Activity Index at registration (β=0.09; 95% CI, 0.03-0.12). Reducing the accumulation of chronic damage in SLE patients might be possible with the concomitant use of immunosuppressants and tight control of disease activity.
AB - Chronic damage accumulation affects not only mortality but also quality of life in patients with systemic lupus erythematosus (SLE). Risk factors for chronic damage were explored in SLE through different onset eras. Two hundred forty-five patients at Okayama University Hospital and Showa University Hospital were divided into three groups based on the onset era: a past-onset group (onset before 1995; n=83), middle-onset group (1996-2009; n=88), and recent-onset group (after 2010; n=74). The mean Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) score as an index of chronic damage was 1.93, 1.24, and 0.53 in the past-, middle-, and recent-onset groups, respectively. In the pastonset group, the total SDI score was significantly associated with glucocorticoid monotherapy by linear regression analysis (β-coefficient [β]=0.63; 95% confidence interval [CI], 0.21-1.05) and C-reactive protein levels (β=0.67; 95% CI, 0.27-1.07). In the middle-onset group, the total SDI score was significantly associated with the SLE Disease Activity Index at registration (β=0.09; 95% CI, 0.03-0.12). Reducing the accumulation of chronic damage in SLE patients might be possible with the concomitant use of immunosuppressants and tight control of disease activity.
KW - Chronic damage
KW - Disease activity
KW - Disease duration
KW - Glucocorticoids
KW - Systemic lupus erythematosus
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M3 - Article
C2 - 32577016
AN - SCOPUS:85087007305
VL - 74
SP - 191
EP - 198
JO - Acta Medica Okayama
JF - Acta Medica Okayama
SN - 0386-300X
IS - 3
ER -