Risk factors associated with local recurrence of early gastric cancers after endoscopic submucosal dissection

Ryuta Takenaka, Yoshiro Kawahara, Hiroyuki Okada, Keisuke Hori, Masafumi Inoue, Seiji Kawano, Daisuke Tanioka, Takao Tsuzuki, Satoru Yagi, Jun Kato, Masayuki Uemura, Nobuya Ohara, Tadashi Yoshino, Atsushi Imagawa, Shigeatsu Fujiki, Rie Takata, Kazuhide Yamamoto

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Background: Although endoscopic submucosal dissection (ESD) is expected to reduce the local recurrence of gastric cancers, we still experience cases of recurrence after an ESD. Objective: To characterize clinical and pathologic features of cases with local recurrence of early gastric cancer after an ESD. Design: A prospective cohort study. Setting and Patients: A total of 306 patients with gastric cancers removed by ESD at Okayama University Hospital and Tsuyama Central Hospital between March 2001 and December 2005 were enrolled. Intervention: ESD. Main Outcome Measurement: Local recurrence. Results: The incidence of a complete en bloc resection was 80.4% when pathologically evaluated. Within a median follow-up period of 26 months (12-64 months), a local recurrence was found in 7 cases, all of which had been declared incomplete resections. One patient underwent a second ESD, and the remaining 6 underwent a surgical resection. All removed lesions were mucosal cancers. No lymph-node metastases were found in patients with a surgical resection. There was a significant correlation between the incidence of an incomplete resection and that of a local recurrence (P <.0001). Among the clinical characteristics, tumor size (>30 mm vs

Original languageEnglish
Pages (from-to)887-894
Number of pages8
JournalGastrointestinal Endoscopy
Issue number5
Publication statusPublished - Nov 2008


ASJC Scopus subject areas

  • Gastroenterology
  • Radiology Nuclear Medicine and imaging

Cite this

Takenaka, R., Kawahara, Y., Okada, H., Hori, K., Inoue, M., Kawano, S., Tanioka, D., Tsuzuki, T., Yagi, S., Kato, J., Uemura, M., Ohara, N., Yoshino, T., Imagawa, A., Fujiki, S., Takata, R., & Yamamoto, K. (2008). Risk factors associated with local recurrence of early gastric cancers after endoscopic submucosal dissection. Gastrointestinal Endoscopy, 68(5), 887-894. https://doi.org/10.1016/j.gie.2008.03.1089