Ring-like enhancement of focal nodular hyperplasia with hepatobiliary-phase Gd-EOB-DTPA-enhanced magnetic resonance imaging: Radiological-pathological correlation

Hiroyasu Fujiwara, Shigeki Sekine, Hiroaki Onaya, Kazuaki Shimada, Rintaro Mikata, Yasuaki Arai

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

We report a case of focal nodular hyperplasia in a patient for whom gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)- enhanced magnetic resonance imaging (MRI) and histological analysis results were available. Dynamic contrast-enhanced computed tomography showed a well-defi ned hypervascular lesion 14 mm in diameter with no visible central scars. Gd-EOB-DTPA-enhanced MRI demonstrated strong peripheral enhancement of the lesion during the hepatobiliary phase, resulting in ring-like enhancement. The pathology examination revealed that the lesion was focal nodular hyperplasia (FNH). Immunohistochemistry showed positive expression of OATP8 in the hepatocytes in the peripheral areas of the lesion, whereas expression of OATP8 was lacking in hepatocytes surrounding the central radiating scar. Ring-like enhancement during the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI may be an important clue for the diagnosis of small FNH.

Original languageEnglish
Pages (from-to)739-743
Number of pages5
JournalJapanese Journal of Radiology
Volume29
Issue number10
DOIs
Publication statusPublished - Dec 2011
Externally publishedYes

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Focal Nodular Hyperplasia
Pentetic Acid
Gadolinium
Magnetic Resonance Imaging
Cicatrix
Hepatocytes
Immunohistochemistry
Tomography
Pathology

Keywords

  • Focal nodular hyperplasia
  • Gd-EOB-DTPA
  • MRI
  • Organic anion transporter

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Ring-like enhancement of focal nodular hyperplasia with hepatobiliary-phase Gd-EOB-DTPA-enhanced magnetic resonance imaging : Radiological-pathological correlation. / Fujiwara, Hiroyasu; Sekine, Shigeki; Onaya, Hiroaki; Shimada, Kazuaki; Mikata, Rintaro; Arai, Yasuaki.

In: Japanese Journal of Radiology, Vol. 29, No. 10, 12.2011, p. 739-743.

Research output: Contribution to journalArticle

Fujiwara, Hiroyasu ; Sekine, Shigeki ; Onaya, Hiroaki ; Shimada, Kazuaki ; Mikata, Rintaro ; Arai, Yasuaki. / Ring-like enhancement of focal nodular hyperplasia with hepatobiliary-phase Gd-EOB-DTPA-enhanced magnetic resonance imaging : Radiological-pathological correlation. In: Japanese Journal of Radiology. 2011 ; Vol. 29, No. 10. pp. 739-743.
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