Riluzole rapidly attenuates hyperemotional responses in olfactory bulbectomized rats, an animal model of depression

Kou Takahashi, Hiroyasu Murasawa, Kazumasa Yamaguchi, Misa Yamada, Akiko Nakatani, Masumi Yoshida, Takashi Iwai, Masatoshi Inagaki, Mitsuhiko Yamada, Akiyoshi Saitoh

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Growing evidence indicates that the glutamatergic neurotransmitter system is central to the neurobiology and treatment of depression. Riluzole, a drug currently used to slow the progression of amyotrophic lateral sclerosis (ALS), directly affects the glutamatergic system. In this study, we investigated the effects of riluzole in olfactory bulbectomy (OBX) rats, an animal model of depression. The olfactory bulbs in rats were removed by suction. The emotionality of rats was measured by scoring their responses to given stimuli, i.e., attack, startle, struggle, and fight responses. The OBX rats chronically treated with vehicle for 7 days at 14 days following surgery showed significant increases in emotionality responses. Single (1st day administration) and subchronic (7th day administration) riluzole treatment (1-10. mg/kg, po) significantly and dose-dependently reduced hyperemotional responses in OBX rats. Both single and subchronic riluzole treatment (10. mg/kg, po) had no significant effects on the emotional responses in sham operated rats. In addition, we demonstrated that single riluzole treatment (10. mg/kg, po) significantly decreased extracellular glutamate levels in medial prefrontal cortex of OBX rats by in vivo microdialysis. We provide the first experimental evidence that riluzole rapidly attenuated hyperemotional responses in OBX rats, an animal model of depression.

Original languageEnglish
Pages (from-to)46-52
Number of pages7
JournalBehavioural Brain Research
Volume216
Issue number1
DOIs
Publication statusPublished - Jan 1 2011
Externally publishedYes

Keywords

  • Animal model
  • Antidepressant
  • Depression
  • Microdialysis
  • OBX rat
  • Prefrontal cortex

ASJC Scopus subject areas

  • Behavioral Neuroscience

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  • Cite this

    Takahashi, K., Murasawa, H., Yamaguchi, K., Yamada, M., Nakatani, A., Yoshida, M., Iwai, T., Inagaki, M., Yamada, M., & Saitoh, A. (2011). Riluzole rapidly attenuates hyperemotional responses in olfactory bulbectomized rats, an animal model of depression. Behavioural Brain Research, 216(1), 46-52. https://doi.org/10.1016/j.bbr.2010.07.002