TY - JOUR
T1 - Riluzole rapidly attenuates hyperemotional responses in olfactory bulbectomized rats, an animal model of depression
AU - Takahashi, Kou
AU - Murasawa, Hiroyasu
AU - Yamaguchi, Kazumasa
AU - Yamada, Misa
AU - Nakatani, Akiko
AU - Yoshida, Masumi
AU - Iwai, Takashi
AU - Inagaki, Masatoshi
AU - Yamada, Mitsuhiko
AU - Saitoh, Akiyoshi
N1 - Funding Information:
This work was supported by Health Science Research Grants from the Ministry of Health, Labour, and Welfare , and the Ministry of Education, Culture, Sport, Science, and Technology . This manuscript received the English proofreading service by Edanz editing ( http://edanzediting.co.jp/about_english.html ). We are entirely responsible for the scientific content of this manuscript.
PY - 2011/1/1
Y1 - 2011/1/1
N2 - Growing evidence indicates that the glutamatergic neurotransmitter system is central to the neurobiology and treatment of depression. Riluzole, a drug currently used to slow the progression of amyotrophic lateral sclerosis (ALS), directly affects the glutamatergic system. In this study, we investigated the effects of riluzole in olfactory bulbectomy (OBX) rats, an animal model of depression. The olfactory bulbs in rats were removed by suction. The emotionality of rats was measured by scoring their responses to given stimuli, i.e., attack, startle, struggle, and fight responses. The OBX rats chronically treated with vehicle for 7 days at 14 days following surgery showed significant increases in emotionality responses. Single (1st day administration) and subchronic (7th day administration) riluzole treatment (1-10. mg/kg, po) significantly and dose-dependently reduced hyperemotional responses in OBX rats. Both single and subchronic riluzole treatment (10. mg/kg, po) had no significant effects on the emotional responses in sham operated rats. In addition, we demonstrated that single riluzole treatment (10. mg/kg, po) significantly decreased extracellular glutamate levels in medial prefrontal cortex of OBX rats by in vivo microdialysis. We provide the first experimental evidence that riluzole rapidly attenuated hyperemotional responses in OBX rats, an animal model of depression.
AB - Growing evidence indicates that the glutamatergic neurotransmitter system is central to the neurobiology and treatment of depression. Riluzole, a drug currently used to slow the progression of amyotrophic lateral sclerosis (ALS), directly affects the glutamatergic system. In this study, we investigated the effects of riluzole in olfactory bulbectomy (OBX) rats, an animal model of depression. The olfactory bulbs in rats were removed by suction. The emotionality of rats was measured by scoring their responses to given stimuli, i.e., attack, startle, struggle, and fight responses. The OBX rats chronically treated with vehicle for 7 days at 14 days following surgery showed significant increases in emotionality responses. Single (1st day administration) and subchronic (7th day administration) riluzole treatment (1-10. mg/kg, po) significantly and dose-dependently reduced hyperemotional responses in OBX rats. Both single and subchronic riluzole treatment (10. mg/kg, po) had no significant effects on the emotional responses in sham operated rats. In addition, we demonstrated that single riluzole treatment (10. mg/kg, po) significantly decreased extracellular glutamate levels in medial prefrontal cortex of OBX rats by in vivo microdialysis. We provide the first experimental evidence that riluzole rapidly attenuated hyperemotional responses in OBX rats, an animal model of depression.
KW - Animal model
KW - Antidepressant
KW - Depression
KW - Microdialysis
KW - OBX rat
KW - Prefrontal cortex
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U2 - 10.1016/j.bbr.2010.07.002
DO - 10.1016/j.bbr.2010.07.002
M3 - Article
C2 - 20620171
AN - SCOPUS:78149409947
SN - 0166-4328
VL - 216
SP - 46
EP - 52
JO - Behavioural Brain Research
JF - Behavioural Brain Research
IS - 1
ER -