TY - JOUR
T1 - Riluzole produces distinct anxiolytic-like effects in rats without the adverse effects associated with benzodiazepines
AU - Sugiyama, Azusa
AU - Saitoh, Akiyoshi
AU - Iwai, Takashi
AU - Takahashi, Kou
AU - Yamada, Misa
AU - Sasaki-Hamada, Sachie
AU - Oka, Jun Ichiro
AU - Inagaki, Masatoshi
AU - Yamada, Mitsuhiko
N1 - Funding Information:
This work was supported, in part, by research grants from Health Science Research Grants from the Japanese Ministry of Health, Labour, and Welfare and the Japan Foundation for Neuroscience and Mental Health . This manuscript was thoroughly checked for English grammar and spelling by a professional scientific editing company (Edanz Editing; http://edanzediting.co.jp/about english.html ). We are entirely responsible for the scientific content of this manuscript.
PY - 2012/6
Y1 - 2012/6
N2 - In this study, we investigated the anxiolytic-like effect of riluzole using three different innate anxiety models in rats. In the elevated plus-maze test, riluzole significantly increased the time spent in, and entries into, the open arm after 60 min administration. This finding was supported by results obtained from light/dark and open-field tests. The magnitude of the anxiolytic-like effects of riluzole in each of the behavioral models was similar to those produced by a benzodiazepine, diazepam, suggesting that riluzole has a robust anxiolytic-like activity in rats. To clarify the involvement of sodium channels in this anxiolytic activity, we examined the effect of a co-administered sodium channel activator, veratrine. The anxiolytic-like action of riluzole was diminished by veratrine in the elevated plus-maze, light/dark and open-field tests. Based on these results, it is suggested that the anxiolytic mechanism of riluzole is clearly distinct from that of diazepam. In addition, to examine whether riluzole directly and non-selectively affected the GABA A-benzodiazepine receptor complex, we performed three behavioral tests (footprint analysis, Y-maze test and the ethanol-induced sleeping time test) that are closely related to the GABA A-benzodiazepine pathways. In contrast to diazepam, riluzole produced no significant effects in these tests. Here, we provide the first report demonstrating that riluzole produces distinct anxiolytic-like effects in rats without the adverse effects associated with benzodiazepines. Crown
AB - In this study, we investigated the anxiolytic-like effect of riluzole using three different innate anxiety models in rats. In the elevated plus-maze test, riluzole significantly increased the time spent in, and entries into, the open arm after 60 min administration. This finding was supported by results obtained from light/dark and open-field tests. The magnitude of the anxiolytic-like effects of riluzole in each of the behavioral models was similar to those produced by a benzodiazepine, diazepam, suggesting that riluzole has a robust anxiolytic-like activity in rats. To clarify the involvement of sodium channels in this anxiolytic activity, we examined the effect of a co-administered sodium channel activator, veratrine. The anxiolytic-like action of riluzole was diminished by veratrine in the elevated plus-maze, light/dark and open-field tests. Based on these results, it is suggested that the anxiolytic mechanism of riluzole is clearly distinct from that of diazepam. In addition, to examine whether riluzole directly and non-selectively affected the GABA A-benzodiazepine receptor complex, we performed three behavioral tests (footprint analysis, Y-maze test and the ethanol-induced sleeping time test) that are closely related to the GABA A-benzodiazepine pathways. In contrast to diazepam, riluzole produced no significant effects in these tests. Here, we provide the first report demonstrating that riluzole produces distinct anxiolytic-like effects in rats without the adverse effects associated with benzodiazepines. Crown
KW - Behavioral
KW - Elevated plus-maze
KW - GABA
KW - Glutamate
KW - Veratrine
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U2 - 10.1016/j.neuropharm.2012.02.012
DO - 10.1016/j.neuropharm.2012.02.012
M3 - Article
C2 - 22377384
AN - SCOPUS:84859711158
VL - 62
SP - 2489
EP - 2498
JO - Neuropharmacology
JF - Neuropharmacology
SN - 0028-3908
IS - 8
ER -