Abstract
We have previously demonstrated that riluzole has anxiolytic-like effects in rats, without affecting spontaneous alternation performance in the Y-maze test. However, the effects of riluzole on hippocampal synaptic plasticity were still unclear. In this study, we showed that bath application of riluzole did not impair long-term potentiation and long-term depression, whereas a benzodiazepine anxiolytic, diazepam, significantly impaired them. Furthermore, the acquisition of spatial memory in the Morris water maze test was impaired in diazepam-treated but not riluzole-treated rats. We thus provide further evidence for the potential usefulness of riluzole as an anxiolytic that does not cause amnesia.
| Original language | English |
|---|---|
| Pages (from-to) | 232-236 |
| Number of pages | 5 |
| Journal | Journal of Pharmacological Sciences |
| Volume | 122 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2013 |
| Externally published | Yes |
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Keywords
- Amnesia
- Mood and anxiety disorder
- Riluzole
ASJC Scopus subject areas
- Pharmacology
- Molecular Medicine
Cite this
Riluzole does not affect hippocampal synaptic plasticity and spatial memory, which are impaired by diazepam in rats. / Sasaki-Hamada, Sachie; Sacai, Hiroaki; Sugiyama, Azusa; Iijima, Takahiro; Saitoh, Akiyoshi; Inagaki, Masatoshi; Yamada, Mitsuhiko; Oka, Jun Ichiro.
In: Journal of Pharmacological Sciences, Vol. 122, No. 3, 2013, p. 232-236.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Riluzole does not affect hippocampal synaptic plasticity and spatial memory, which are impaired by diazepam in rats
AU - Sasaki-Hamada, Sachie
AU - Sacai, Hiroaki
AU - Sugiyama, Azusa
AU - Iijima, Takahiro
AU - Saitoh, Akiyoshi
AU - Inagaki, Masatoshi
AU - Yamada, Mitsuhiko
AU - Oka, Jun Ichiro
PY - 2013
Y1 - 2013
N2 - We have previously demonstrated that riluzole has anxiolytic-like effects in rats, without affecting spontaneous alternation performance in the Y-maze test. However, the effects of riluzole on hippocampal synaptic plasticity were still unclear. In this study, we showed that bath application of riluzole did not impair long-term potentiation and long-term depression, whereas a benzodiazepine anxiolytic, diazepam, significantly impaired them. Furthermore, the acquisition of spatial memory in the Morris water maze test was impaired in diazepam-treated but not riluzole-treated rats. We thus provide further evidence for the potential usefulness of riluzole as an anxiolytic that does not cause amnesia.
AB - We have previously demonstrated that riluzole has anxiolytic-like effects in rats, without affecting spontaneous alternation performance in the Y-maze test. However, the effects of riluzole on hippocampal synaptic plasticity were still unclear. In this study, we showed that bath application of riluzole did not impair long-term potentiation and long-term depression, whereas a benzodiazepine anxiolytic, diazepam, significantly impaired them. Furthermore, the acquisition of spatial memory in the Morris water maze test was impaired in diazepam-treated but not riluzole-treated rats. We thus provide further evidence for the potential usefulness of riluzole as an anxiolytic that does not cause amnesia.
KW - Amnesia
KW - Mood and anxiety disorder
KW - Riluzole
UR - http://www.scopus.com/inward/record.url?scp=84880816332&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84880816332&partnerID=8YFLogxK
U2 - 10.1254/jphs.13052SC
DO - 10.1254/jphs.13052SC
M3 - Article
VL - 122
SP - 232
EP - 236
JO - Journal of Pharmacological Sciences
JF - Journal of Pharmacological Sciences
SN - 1347-8648
IS - 3
ER -