Riluzole does not affect hippocampal synaptic plasticity and spatial memory, which are impaired by diazepam in rats

Sachie Sasaki-Hamada, Hiroaki Sacai, Azusa Sugiyama, Takahiro Iijima, Akiyoshi Saitoh, Masatoshi Inagaki, Mitsuhiko Yamada, Jun Ichiro Oka

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We have previously demonstrated that riluzole has anxiolytic-like effects in rats, without affecting spontaneous alternation performance in the Y-maze test. However, the effects of riluzole on hippocampal synaptic plasticity were still unclear. In this study, we showed that bath application of riluzole did not impair long-term potentiation and long-term depression, whereas a benzodiazepine anxiolytic, diazepam, significantly impaired them. Furthermore, the acquisition of spatial memory in the Morris water maze test was impaired in diazepam-treated but not riluzole-treated rats. We thus provide further evidence for the potential usefulness of riluzole as an anxiolytic that does not cause amnesia.

Original languageEnglish
Pages (from-to)232-236
Number of pages5
JournalJournal of Pharmacological Sciences
Volume122
Issue number3
DOIs
Publication statusPublished - Aug 2 2013

Keywords

  • Amnesia
  • Mood and anxiety disorder
  • Riluzole

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Fingerprint Dive into the research topics of 'Riluzole does not affect hippocampal synaptic plasticity and spatial memory, which are impaired by diazepam in rats'. Together they form a unique fingerprint.

  • Cite this

    Sasaki-Hamada, S., Sacai, H., Sugiyama, A., Iijima, T., Saitoh, A., Inagaki, M., Yamada, M., & Oka, J. I. (2013). Riluzole does not affect hippocampal synaptic plasticity and spatial memory, which are impaired by diazepam in rats. Journal of Pharmacological Sciences, 122(3), 232-236. https://doi.org/10.1254/jphs.13052SC