Riluzole does not affect hippocampal synaptic plasticity and spatial memory, which are impaired by diazepam in rats

Sachie Sasaki-Hamada; Hiroaki Sacai; Azusa Sugiyama; Takahiro Iijima; Akiyoshi Saitoh; Masatoshi Inagaki; Mitsuhiko Yamada; Jun Ichiro Oka

doi:10.1254/jphs.13052SC

Riluzole does not affect hippocampal synaptic plasticity and spatial memory, which are impaired by diazepam in rats

Sachie Sasaki-Hamada, Hiroaki Sacai, Azusa Sugiyama, Takahiro Iijima, Akiyoshi Saitoh, Masatoshi Inagaki, Mitsuhiko Yamada, Jun Ichiro Oka

University Hospital

Research output: Contribution to journal › Article

10 Citations (Scopus)

Abstract

We have previously demonstrated that riluzole has anxiolytic-like effects in rats, without affecting spontaneous alternation performance in the Y-maze test. However, the effects of riluzole on hippocampal synaptic plasticity were still unclear. In this study, we showed that bath application of riluzole did not impair long-term potentiation and long-term depression, whereas a benzodiazepine anxiolytic, diazepam, significantly impaired them. Furthermore, the acquisition of spatial memory in the Morris water maze test was impaired in diazepam-treated but not riluzole-treated rats. We thus provide further evidence for the potential usefulness of riluzole as an anxiolytic that does not cause amnesia.

Original language	English
Pages (from-to)	232-236
Number of pages	5
Journal	Journal of Pharmacological Sciences
Volume	122
Issue number	3
DOIs	https://doi.org/10.1254/jphs.13052SC
Publication status	Published - Aug 2 2013

Keywords

Amnesia
Mood and anxiety disorder
Riluzole

ASJC Scopus subject areas

Molecular Medicine
Pharmacology

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10.1254/jphs.13052SC

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Riluzole does not affect hippocampal synaptic plasticity and spatial memory, which are impaired by diazepam in rats. / Sasaki-Hamada, Sachie; Sacai, Hiroaki; Sugiyama, Azusa; Iijima, Takahiro; Saitoh, Akiyoshi; Inagaki, Masatoshi; Yamada, Mitsuhiko; Oka, Jun Ichiro.

In: Journal of Pharmacological Sciences, Vol. 122, No. 3, 02.08.2013, p. 232-236.

Research output: Contribution to journal › Article

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