Abstract
We have previously demonstrated that riluzole has anxiolytic-like effects in rats, without affecting spontaneous alternation performance in the Y-maze test. However, the effects of riluzole on hippocampal synaptic plasticity were still unclear. In this study, we showed that bath application of riluzole did not impair long-term potentiation and long-term depression, whereas a benzodiazepine anxiolytic, diazepam, significantly impaired them. Furthermore, the acquisition of spatial memory in the Morris water maze test was impaired in diazepam-treated but not riluzole-treated rats. We thus provide further evidence for the potential usefulness of riluzole as an anxiolytic that does not cause amnesia.
| Original language | English |
|---|---|
| Pages (from-to) | 232-236 |
| Number of pages | 5 |
| Journal | Journal of Pharmacological Sciences |
| Volume | 122 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Aug 2 2013 |
Keywords
- Amnesia
- Mood and anxiety disorder
- Riluzole
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology
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Cite this
Sasaki-Hamada, S., Sacai, H., Sugiyama, A., Iijima, T., Saitoh, A., Inagaki, M., Yamada, M., & Oka, J. I. (2013). Riluzole does not affect hippocampal synaptic plasticity and spatial memory, which are impaired by diazepam in rats. Journal of Pharmacological Sciences, 122(3), 232-236. https://doi.org/10.1254/jphs.13052SC