Riluzole does not affect hippocampal synaptic plasticity and spatial memory, which are impaired by diazepam in rats

Sachie Sasaki-Hamada, Hiroaki Sacai, Azusa Sugiyama, Takahiro Iijima, Akiyoshi Saitoh, Masatoshi Inagaki, Mitsuhiko Yamada, Jun Ichiro Oka

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We have previously demonstrated that riluzole has anxiolytic-like effects in rats, without affecting spontaneous alternation performance in the Y-maze test. However, the effects of riluzole on hippocampal synaptic plasticity were still unclear. In this study, we showed that bath application of riluzole did not impair long-term potentiation and long-term depression, whereas a benzodiazepine anxiolytic, diazepam, significantly impaired them. Furthermore, the acquisition of spatial memory in the Morris water maze test was impaired in diazepam-treated but not riluzole-treated rats. We thus provide further evidence for the potential usefulness of riluzole as an anxiolytic that does not cause amnesia.

Original languageEnglish
Pages (from-to)232-236
Number of pages5
JournalJournal of Pharmacological Sciences
Volume122
Issue number3
DOIs
Publication statusPublished - 2013
Externally publishedYes

Fingerprint

Riluzole
Neuronal Plasticity
Diazepam
Anti-Anxiety Agents
Amnesia
Long-Term Potentiation
Benzodiazepines
Baths
Spatial Memory
Depression
Water

Keywords

  • Amnesia
  • Mood and anxiety disorder
  • Riluzole

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine

Cite this

Sasaki-Hamada, S., Sacai, H., Sugiyama, A., Iijima, T., Saitoh, A., Inagaki, M., ... Oka, J. I. (2013). Riluzole does not affect hippocampal synaptic plasticity and spatial memory, which are impaired by diazepam in rats. Journal of Pharmacological Sciences, 122(3), 232-236. https://doi.org/10.1254/jphs.13052SC

Riluzole does not affect hippocampal synaptic plasticity and spatial memory, which are impaired by diazepam in rats. / Sasaki-Hamada, Sachie; Sacai, Hiroaki; Sugiyama, Azusa; Iijima, Takahiro; Saitoh, Akiyoshi; Inagaki, Masatoshi; Yamada, Mitsuhiko; Oka, Jun Ichiro.

In: Journal of Pharmacological Sciences, Vol. 122, No. 3, 2013, p. 232-236.

Research output: Contribution to journalArticle

Sasaki-Hamada, S, Sacai, H, Sugiyama, A, Iijima, T, Saitoh, A, Inagaki, M, Yamada, M & Oka, JI 2013, 'Riluzole does not affect hippocampal synaptic plasticity and spatial memory, which are impaired by diazepam in rats', Journal of Pharmacological Sciences, vol. 122, no. 3, pp. 232-236. https://doi.org/10.1254/jphs.13052SC
Sasaki-Hamada, Sachie ; Sacai, Hiroaki ; Sugiyama, Azusa ; Iijima, Takahiro ; Saitoh, Akiyoshi ; Inagaki, Masatoshi ; Yamada, Mitsuhiko ; Oka, Jun Ichiro. / Riluzole does not affect hippocampal synaptic plasticity and spatial memory, which are impaired by diazepam in rats. In: Journal of Pharmacological Sciences. 2013 ; Vol. 122, No. 3. pp. 232-236.
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