Rigid hydroxyapatite-alginate beads for sustained release of paclitaxel

T. Ikoma, Tomohiko Yoshioka, S. Nakamura, N. Hanagata, T. Abe, M. Sakane, N. Ochiai, J. Tanaka

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Rigid hydroxyapatite (HAp)-alginate beads were prepared as drug delivery carriers for an anti-cancer drug, paclitaxel (Taxol). Paclitaxel was loaded into the HAp microparticle in process of a spray-drying technique. The HAp-alginate beads including paclitaxel were obtained by a droplet method into barium solution as ionic cross-linkage and dehydration. Cross-sectional analyses indicated the homogeneity of HAp microparticles and barium ions inside the bead. The ratio of alginate to HAp in the beads dominated both mechanical and swelling properties. Drug-release experiment demonstrated the sustained release of paclitaxel from the beads cross-linked with barium ion for 7 days.

Original languageEnglish
Pages (from-to)535-538
Number of pages4
JournalKey Engineering Materials
Volume361-363 I
Publication statusPublished - 2008
Externally publishedYes

Fingerprint

Alginate
Durapatite
Paclitaxel
Hydroxyapatite
Barium
Ions
Spray drying
Dehydration
Drug delivery
Pharmaceutical Preparations
Swelling
alginic acid
Experiments

Keywords

  • Barium
  • DDS
  • Hydroxyapatite (HAp)
  • Paclitaxel (Taxol)
  • Sodium alginate
  • Spray-dry

ASJC Scopus subject areas

  • Ceramics and Composites
  • Chemical Engineering (miscellaneous)

Cite this

Ikoma, T., Yoshioka, T., Nakamura, S., Hanagata, N., Abe, T., Sakane, M., ... Tanaka, J. (2008). Rigid hydroxyapatite-alginate beads for sustained release of paclitaxel. Key Engineering Materials, 361-363 I, 535-538.

Rigid hydroxyapatite-alginate beads for sustained release of paclitaxel. / Ikoma, T.; Yoshioka, Tomohiko; Nakamura, S.; Hanagata, N.; Abe, T.; Sakane, M.; Ochiai, N.; Tanaka, J.

In: Key Engineering Materials, Vol. 361-363 I, 2008, p. 535-538.

Research output: Contribution to journalArticle

Ikoma, T, Yoshioka, T, Nakamura, S, Hanagata, N, Abe, T, Sakane, M, Ochiai, N & Tanaka, J 2008, 'Rigid hydroxyapatite-alginate beads for sustained release of paclitaxel', Key Engineering Materials, vol. 361-363 I, pp. 535-538.
Ikoma T, Yoshioka T, Nakamura S, Hanagata N, Abe T, Sakane M et al. Rigid hydroxyapatite-alginate beads for sustained release of paclitaxel. Key Engineering Materials. 2008;361-363 I:535-538.
Ikoma, T. ; Yoshioka, Tomohiko ; Nakamura, S. ; Hanagata, N. ; Abe, T. ; Sakane, M. ; Ochiai, N. ; Tanaka, J. / Rigid hydroxyapatite-alginate beads for sustained release of paclitaxel. In: Key Engineering Materials. 2008 ; Vol. 361-363 I. pp. 535-538.
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