Rigid hydroxyapatite-alginate beads for sustained release of paclitaxel

T. Ikoma, Tomohiko Yoshioka, S. Nakamura, N. Hanagata, T. Abe, M. Sakane, N. Ochiai, J. Tanaka

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2 Citations (Scopus)

Abstract

Rigid hydroxyapatite (HAp)-alginate beads were prepared as drug delivery carriers for an anti-cancer drug, paclitaxel (Taxol). Paclitaxel was loaded into the HAp microparticle in process of a spray-drying technique. The HAp-alginate beads including paclitaxel were obtained by a droplet method into barium solution as ionic cross-linkage and dehydration. Cross-sectional analyses indicated the homogeneity of HAp microparticles and barium ions inside the bead. The ratio of alginate to HAp in the beads dominated both mechanical and swelling properties. Drug-release experiment demonstrated the sustained release of paclitaxel from the beads cross-linked with barium ion for 7 days.

Original languageEnglish
Pages (from-to)535-538
Number of pages4
JournalKey Engineering Materials
Volume361-363 I
Publication statusPublished - 2008
Externally publishedYes

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Keywords

  • Barium
  • DDS
  • Hydroxyapatite (HAp)
  • Paclitaxel (Taxol)
  • Sodium alginate
  • Spray-dry

ASJC Scopus subject areas

  • Ceramics and Composites
  • Chemical Engineering (miscellaneous)

Cite this

Ikoma, T., Yoshioka, T., Nakamura, S., Hanagata, N., Abe, T., Sakane, M., Ochiai, N., & Tanaka, J. (2008). Rigid hydroxyapatite-alginate beads for sustained release of paclitaxel. Key Engineering Materials, 361-363 I, 535-538.