TY - JOUR
T1 - Right ventricular stiffness constant as a predictor of postoperative hemodynamics in patients with hypoplastic right ventricle
T2 - A theoretical analysis
AU - Shimizu, Shuji
AU - Shishido, Toshiaki
AU - Une, Dai
AU - Kamiya, Atsunori
AU - Kawada, Toru
AU - Sano, Shunji
AU - Sugimachi, Masaru
N1 - Funding Information:
Acknowledgments This study was supported by Health and Labor Sciences Research Grants (H18-nano-Ippan-003, H19-nano-Ippan-009, H20-katsudo-Shitei-007 and H21-nano-Ippan-005) from the Ministry of Health, Labor and Welfare of Japan, by Grants-in-Aid for Scientific Research (No. 20390462) from the Ministry of Education, Culture, Sports, Science and Technology in Japan, and by the Industrial Technology Research Grant Program from New Energy and Industrial Technology Development Organization (NEDO) of Japan.
PY - 2010/5
Y1 - 2010/5
N2 - One and a half ventricle repair (1.5VR) is a surgical option for hypoplastic right ventricle (RV). The benefits of this procedure compared to biventricular repair (2VR) or Fontan operation remain unsettled. To compare postoperative hemodynamics, we performed a theoretical analysis using a computational model based on lumpedparameter state-variable equations. We varied the RV stiffness constant (BRV) to simulate the various RV hypoplasia, and estimated hemodynamics for a given BRV. With B RV < 150% of normal, cardiac output was the largest in 2VR. With BRV 150%, cardiac output became larger in 1.5VR than in 2VR. With BRV> 250%, RV end-diastolic volume was almost the same between 1.5VR and 2VR, and a rapid increase in atrial pressure precluded the use of 1.5VR. These results indicate that the beneficial effect of 1.5VR depends on the RV stiffness constant. Determination of management strategy should not only be based on the morphologic parameters but also on the physiological properties of RV.
AB - One and a half ventricle repair (1.5VR) is a surgical option for hypoplastic right ventricle (RV). The benefits of this procedure compared to biventricular repair (2VR) or Fontan operation remain unsettled. To compare postoperative hemodynamics, we performed a theoretical analysis using a computational model based on lumpedparameter state-variable equations. We varied the RV stiffness constant (BRV) to simulate the various RV hypoplasia, and estimated hemodynamics for a given BRV. With B RV < 150% of normal, cardiac output was the largest in 2VR. With BRV 150%, cardiac output became larger in 1.5VR than in 2VR. With BRV> 250%, RV end-diastolic volume was almost the same between 1.5VR and 2VR, and a rapid increase in atrial pressure precluded the use of 1.5VR. These results indicate that the beneficial effect of 1.5VR depends on the RV stiffness constant. Determination of management strategy should not only be based on the morphologic parameters but also on the physiological properties of RV.
KW - Computational model
KW - Hypoplastic right ventricle
KW - One and a half ventricle repair
KW - Right ventricular stiffness
UR - http://www.scopus.com/inward/record.url?scp=77953536404&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953536404&partnerID=8YFLogxK
U2 - 10.1007/s12576-010-0086-y
DO - 10.1007/s12576-010-0086-y
M3 - Article
C2 - 20131025
AN - SCOPUS:77953536404
VL - 60
SP - 205
EP - 212
JO - Journal of Physiological Sciences
JF - Journal of Physiological Sciences
SN - 1880-6546
IS - 3
ER -