Right ventricular stiffness constant as a predictor of postoperative hemodynamics in patients with hypoplastic right ventricle: A theoretical analysis

Shuji Shimizu, Toshiaki Shishido, Dai Une, Atsunori Kamiya, Toru Kawada, Shunji Sano, Masaru Sugimachi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

One and a half ventricle repair (1.5VR) is a surgical option for hypoplastic right ventricle (RV). The benefits of this procedure compared to biventricular repair (2VR) or Fontan operation remain unsettled. To compare postoperative hemodynamics, we performed a theoretical analysis using a computational model based on lumpedparameter state-variable equations. We varied the RV stiffness constant (BRV) to simulate the various RV hypoplasia, and estimated hemodynamics for a given BRV. With B RV < 150% of normal, cardiac output was the largest in 2VR. With BRV 150%, cardiac output became larger in 1.5VR than in 2VR. With BRV> 250%, RV end-diastolic volume was almost the same between 1.5VR and 2VR, and a rapid increase in atrial pressure precluded the use of 1.5VR. These results indicate that the beneficial effect of 1.5VR depends on the RV stiffness constant. Determination of management strategy should not only be based on the morphologic parameters but also on the physiological properties of RV.

Original languageEnglish
Pages (from-to)205-212
Number of pages8
JournalJournal of Physiological Sciences
Volume60
Issue number3
DOIs
Publication statusPublished - May 2010

Keywords

  • Computational model
  • Hypoplastic right ventricle
  • One and a half ventricle repair
  • Right ventricular stiffness

ASJC Scopus subject areas

  • Physiology

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