Right ventricle of patients undergoing congenital cardiac surgery differentially expresses Haem oxygenase-1 and heat shock protein 70 genes

M. Takeuchi, Takatoru Takahashi, N. Taga, T. Iwasaki, K. Ohe, H. Shimizu, T. Suzuki, H. Nakatsuka, M. Yokoyama, S. Sano, R. Akagi, K. Morita

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10 Citations (Scopus)

Abstract

Reactive oxygen species are implicated in the pathogenesis of cardiac hypertrophy. Haem oxygenase-1 (HO-1), the rate-limiting enzyme in haem catabolism, is induced by oxidative stress and confers protection against oxidative tissue injuries. We used Northern blotting to examine expression of HO-1 and heat shock protein 70 (HSP70) in the hypertrophic cardiac muscle of eight patients (one infant and seven children) who underwent surgery for congenital heart disease. Levels of HO-1 and HSP70 mRNA were significantly increased in all specimens, but the orders of magnitude of the increases were different, suggesting that the genes expressing HO-1 and HSP70 are regulated separately.

Original languageEnglish
Pages (from-to)413-417
Number of pages5
JournalJournal of International Medical Research
Volume31
Issue number5
DOIs
Publication statusPublished - Jan 1 2003

Keywords

  • Cardiac hypertrophy
  • Cardiac surgery
  • Congenital heart disease
  • Gene expression
  • Haem oxygenase-1
  • Heat shock protein 70
  • Human heart

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

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    Takeuchi, M., Takahashi, T., Taga, N., Iwasaki, T., Ohe, K., Shimizu, H., Suzuki, T., Nakatsuka, H., Yokoyama, M., Sano, S., Akagi, R., & Morita, K. (2003). Right ventricle of patients undergoing congenital cardiac surgery differentially expresses Haem oxygenase-1 and heat shock protein 70 genes. Journal of International Medical Research, 31(5), 413-417. https://doi.org/10.1177/147323000303100509