Right ventricle of patients undergoing congenital cardiac surgery differentially expresses Haem oxygenase-1 and heat shock protein 70 genes

M. Takeuchi, Takatoru Takahashi, N. Taga, Tatsuo Iwasaki, K. Ohe, H. Shimizu, T. Suzuki, H. Nakatsuka, M. Yokoyama, S. Sano, R. Akagi, K. Morita

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Reactive oxygen species are implicated in the pathogenesis of cardiac hypertrophy. Haem oxygenase-1 (HO-1), the rate-limiting enzyme in haem catabolism, is induced by oxidative stress and confers protection against oxidative tissue injuries. We used Northern blotting to examine expression of HO-1 and heat shock protein 70 (HSP70) in the hypertrophic cardiac muscle of eight patients (one infant and seven children) who underwent surgery for congenital heart disease. Levels of HO-1 and HSP70 mRNA were significantly increased in all specimens, but the orders of magnitude of the increases were different, suggesting that the genes expressing HO-1 and HSP70 are regulated separately.

Original languageEnglish
Pages (from-to)413-417
Number of pages5
JournalJournal of International Medical Research
Volume31
Issue number5
Publication statusPublished - Sep 2003

Fingerprint

Heme Oxygenase (Decyclizing)
HSP70 Heat-Shock Proteins
Surgery
Thoracic Surgery
Heart Ventricles
Genes
Oxidative stress
Cardiomegaly
Heme
Northern Blotting
Muscle
Heart Diseases
Reactive Oxygen Species
Myocardium
Oxidative Stress
Tissue
Messenger RNA
Wounds and Injuries
Enzymes

Keywords

  • Cardiac hypertrophy
  • Cardiac surgery
  • Congenital heart disease
  • Gene expression
  • Haem oxygenase-1
  • Heat shock protein 70
  • Human heart

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Right ventricle of patients undergoing congenital cardiac surgery differentially expresses Haem oxygenase-1 and heat shock protein 70 genes. / Takeuchi, M.; Takahashi, Takatoru; Taga, N.; Iwasaki, Tatsuo; Ohe, K.; Shimizu, H.; Suzuki, T.; Nakatsuka, H.; Yokoyama, M.; Sano, S.; Akagi, R.; Morita, K.

In: Journal of International Medical Research, Vol. 31, No. 5, 09.2003, p. 413-417.

Research output: Contribution to journalArticle

Takeuchi, M, Takahashi, T, Taga, N, Iwasaki, T, Ohe, K, Shimizu, H, Suzuki, T, Nakatsuka, H, Yokoyama, M, Sano, S, Akagi, R & Morita, K 2003, 'Right ventricle of patients undergoing congenital cardiac surgery differentially expresses Haem oxygenase-1 and heat shock protein 70 genes', Journal of International Medical Research, vol. 31, no. 5, pp. 413-417.
Takeuchi, M. ; Takahashi, Takatoru ; Taga, N. ; Iwasaki, Tatsuo ; Ohe, K. ; Shimizu, H. ; Suzuki, T. ; Nakatsuka, H. ; Yokoyama, M. ; Sano, S. ; Akagi, R. ; Morita, K. / Right ventricle of patients undergoing congenital cardiac surgery differentially expresses Haem oxygenase-1 and heat shock protein 70 genes. In: Journal of International Medical Research. 2003 ; Vol. 31, No. 5. pp. 413-417.
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