Rhodacyanine dyes as antimalarials. 1. Preliminary evaluation of their activity and toxicity

Kiyosei Takasu, Hiroshi Inoue, Hye Sook Kim, Makoto Suzuki, Tadao Shishido, Yusuke Wataya, Masataka Ihara

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

The rhodacyanine dye MKT-077 (1), a potent antitumor agent, was found to possess strong in vitro activity against Plasmodium falciparum and a low cytotoxicity. Several new rhodacyanine dyes related to 1, containing a variety of linked heterocyclic moieties, were synthesized, and their antimalarial potencies were evaluated. The synthetic rhodacyanines were found to have EC50 values against P. falciparum in vitro in the range of 4-300 nM. Several compounds in this series have remarkable selective toxicity profiles (> 100).

Original languageEnglish
Pages (from-to)995-998
Number of pages4
JournalJournal of medicinal chemistry
Volume45
Issue number5
DOIs
Publication statusPublished - Feb 28 2002

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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