Rhenium-catalyzed synthesis of multisubstituted aromatic compounds via C-C single-bond cleavage

Yoichiro Kuninobu, Hisatsugu Takata, Atsushi Kawata, Kazuhiko Takai

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(Chemical Equation Presented) A reaction between a β-keto ester and an acetylene in the presence of a rhenium complex, [ReBr(CO)3(thf)] 2, as a catalyst, provided a 2-pyranone derivative in excellent yield via retro-aldol reaction (C-C single bond cleavage). By adding an acetylene-bearing ester group(s) after the formation of 2-pyranones, an aromatization reaction proceeded and multisubstituted aromatic compounds were obtained in good to excellent yields.

Original languageEnglish
Pages (from-to)3133-3135
Number of pages3
JournalOrganic Letters
Issue number14
Publication statusPublished - 2008


ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry
  • Molecular Medicine

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