RhCl3/amine-catalyzed [2+2+2] cyclization of alkynes

Kenta Yoshida; Ichiro Morimoto; Koichi Mitsudo; Hideo Tanaka

doi:10.1016/j.tet.2008.03.079

RhCl₃/amine-catalyzed [2+2+2] cyclization of alkynes

Kenta Yoshida, Ichiro Morimoto, Koichi Mitsudo, Hideo Tanaka

Research output: Contribution to journal › Article

42 Citations (Scopus)

Abstract

The RhCl₃·3H₂O/i-Pr₂NEt-catalyzed [2+2+2] cyclotrimerization of alkynes has been achieved. The reaction can be widely used for various alkynes and provides tri- or hexa-substituted benzenes regioselectively in high yields. The [2+2+2] cycloaddition of diynes and alkynes is also developed, and it affords benzene derivatives in moderate to high yields.

Original language	English
Pages (from-to)	5800-5807
Number of pages	8
Journal	Tetrahedron
Volume	64
Issue number	24
DOIs	https://doi.org/10.1016/j.tet.2008.03.079
Publication status	Published - Jun 9 2008

Keywords

Cyclotrimerization
Hexa-substituted benzene
Rh/amine catalyst

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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Yoshida, K., Morimoto, I., Mitsudo, K., & Tanaka, H. (2008). RhCl₃/amine-catalyzed [2+2+2] cyclization of alkynes. Tetrahedron, 64(24), 5800-5807. https://doi.org/10.1016/j.tet.2008.03.079

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AU - Mitsudo, Koichi

AU - Tanaka, Hideo

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