Abstract
The RhCl3·3H2O/i-Pr2NEt-catalyzed [2+2+2] cyclotrimerization of alkynes has been achieved. The reaction can be widely used for various alkynes and provides tri- or hexa-substituted benzenes regioselectively in high yields. The [2+2+2] cycloaddition of diynes and alkynes is also developed, and it affords benzene derivatives in moderate to high yields.
Original language | English |
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Pages (from-to) | 5800-5807 |
Number of pages | 8 |
Journal | Tetrahedron |
Volume | 64 |
Issue number | 24 |
DOIs | |
Publication status | Published - Jun 9 2008 |
Keywords
- Cyclotrimerization
- Hexa-substituted benzene
- Rh/amine catalyst
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry