RhCl3/amine-catalyzed [2+2+2] cyclization of alkynes

Kenta Yoshida, Ichiro Morimoto, Koichi Mitsudo, Hideo Tanaka

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)


The RhCl3·3H2O/i-Pr2NEt-catalyzed [2+2+2] cyclotrimerization of alkynes has been achieved. The reaction can be widely used for various alkynes and provides tri- or hexa-substituted benzenes regioselectively in high yields. The [2+2+2] cycloaddition of diynes and alkynes is also developed, and it affords benzene derivatives in moderate to high yields.

Original languageEnglish
Pages (from-to)5800-5807
Number of pages8
Issue number24
Publication statusPublished - Jun 9 2008


  • Cyclotrimerization
  • Hexa-substituted benzene
  • Rh/amine catalyst

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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