Revised structures of gambiriins A1, A2, B1, and B2, chalcane-flavan dimers from gambir (Uncaria gambir extract)

Shoko Taniguchi, Kayo Kuroda, Kou Ichi Doi, Masahiro Tanabe, Takashi Shibata, Takashi Yoshida, Tsutomu Hatano

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Gambir, the aqueous extract from Uncaria gambir (Rubiaceae), has been used as an astringent medicine in Asian countries. Investigation of the constituents in the extract led to the isolation of four chalcane-flavan dimers, gambiriin A1 (6), A2 (7), B1 (8), and B2 (9), in addition to (+)-catechin (1), (+)-epicatechin (2), and dimeric proanthocyanidins, procyanidin B1 (3), procyanidin B3 (4), and gambiriin C (5). The spectroscopic and chemical data obtained in the present study indicated that their previously proposed structures 6a, 7a, 8a, and 9a should be revised to 6, 7, 8, and 9, respectively.

Original languageEnglish
Pages (from-to)268-272
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Volume55
Issue number2
DOIs
Publication statusPublished - Feb 2007

Fingerprint

Uncaria
Catechin
varespladib methyl
Dimers
Astringents
Proanthocyanidins
Rubiaceae
Medicine

Keywords

  • Catechin
  • Chalcane-flavan dimer
  • Gambir
  • Gambiriin
  • Uncaria gambir

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

Revised structures of gambiriins A1, A2, B1, and B2, chalcane-flavan dimers from gambir (Uncaria gambir extract). / Taniguchi, Shoko; Kuroda, Kayo; Doi, Kou Ichi; Tanabe, Masahiro; Shibata, Takashi; Yoshida, Takashi; Hatano, Tsutomu.

In: Chemical and Pharmaceutical Bulletin, Vol. 55, No. 2, 02.2007, p. 268-272.

Research output: Contribution to journalArticle

Taniguchi, Shoko ; Kuroda, Kayo ; Doi, Kou Ichi ; Tanabe, Masahiro ; Shibata, Takashi ; Yoshida, Takashi ; Hatano, Tsutomu. / Revised structures of gambiriins A1, A2, B1, and B2, chalcane-flavan dimers from gambir (Uncaria gambir extract). In: Chemical and Pharmaceutical Bulletin. 2007 ; Vol. 55, No. 2. pp. 268-272.
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AU - Doi, Kou Ichi

AU - Tanabe, Masahiro

AU - Shibata, Takashi

AU - Yoshida, Takashi

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