Review of the diagnosis of gastrointestinal lanthanum deposition

Masaya Iwamuro, Haruo Urata, Takehiro Tanaka, Hiroyuki Okada

Research output: Contribution to journalReview article

Abstract

Lanthanum carbonate is used for treatment of hyperphosphatemia mostly in patients with chronic renal failure. Although lanthanum carbonate is safe, recently, lanthanum deposition in the gastrointestinal mucosa of patients has been reported in the literature. This review provides an overview of gastroduodenal lanthanum deposition and focuses on disease's endoscopic, radiological, and histological features, prevalence, and outcome, by reviewing relevant clinical studies, case reports, and basic research findings, to better understand the endoscopic manifestation of gastrointestinal lanthanum deposition. The possible relationship between gastric lanthanum deposition pattern and gastric mucosal atrophy is also illustrated; in patients without gastric mucosal atrophy, gastric lanthanum deposition appears as diffuse white lesions in the posterior wall and lesser curvature of the gastric body. In the gastric mucosa with atrophy, lanthanum-related lesions likely appear as annular or granular whitish lesions. Moreover, these white lesions are probably more frequently observed in the lower part of the stomach, where intestinal metaplasia begins.

Original languageEnglish
Pages (from-to)1439-1449
Number of pages11
JournalWorld journal of gastroenterology
Volume26
Issue number13
DOIs
Publication statusPublished - Apr 7 2020

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Keywords

  • Energy-dispersive X-ray spectrometry
  • Gastrointestinal endoscopy
  • Hyperphosphatemia
  • Lanthanum carbonate
  • Lanthanum phosphate
  • Scanning electron microscopy

ASJC Scopus subject areas

  • Gastroenterology

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