Review: Functional specification in the Drosophila endoderm

Research output: Contribution to journalReview article

35 Citations (Scopus)

Abstract

The discovery of homeobox gene clusters led us to realize that the mechanisms for body patterning and other developmental programs are evolutionally-conserved in vertebrates and invertebrates. The endoderm contributes to the lining of the gut and associated organs such as the liver and pancreas, which are critical for physiological functions. Our knowledge of endoderm development is limited; however, recent studies suggest that cooperation between the HNF3/Fork head and GATA transcription factors is crucial for endoderm specification. It is necessary to further understand the mechanism through which cells become functionally organized. Molecular genetic analyses of the Drosophila endoderm would provide insights into this issue. During proventriculus morphogenesis, a simple epithelial tube is folded into a functional multilayered structure, while two functions of midgut copper cells (i.e. copper absorption and acid secretion) can be easily visualized. The homeobox gene defective proventriculus (dve) plays key roles in these functional specifications.

Original languageEnglish
Pages (from-to)383-392
Number of pages10
JournalDevelopment Growth and Differentiation
Volume47
Issue number6
DOIs
Publication statusPublished - Aug 1 2005

Keywords

  • Drosophila
  • Endoderm
  • Functional development
  • Gut

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Review: Functional specification in the Drosophila endoderm'. Together they form a unique fingerprint.

Cite this