Retrotransposons manipulating mammalian skeletal development in chondrocytes

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Retrotransposons are genetic elements that copy and paste themselves in the host genome through transcription, reverse‐transcription, and integration processes. Along with their proliferation in the genome, retrotransposons inevitably modify host genes around the integration sites, and occasionally create novel genes. Even now, a number of retrotransposons are still actively editing our genomes. As such, their profound role in the evolution of mammalian genomes is obvious; thus, their contribution to mammalian skeletal evolution and development is also unquestionable. In mammals, most of the skeletal parts are formed and grown through a process entitled endochondral ossification, in which chondrocytes play central roles. In this review, current knowledge on the evolutional, physiological, and pathological roles of retrotransposons in mammalian chondrocyte differentiation and cartilage development is summarized. The possible biological impact of these mobile genetic elements in the future is also discussed.

Original languageEnglish
Article number1564
JournalInternational journal of molecular sciences
Volume21
Issue number5
DOIs
Publication statusPublished - Mar 1 2020

Keywords

  • Cartilage
  • Chondrocyte
  • Endogenous retrovirus
  • Retrotransposon
  • Skeletal development

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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