TY - JOUR
T1 - Retrospective analysis of 133 patients with cutaneous lymphomas from a single Japanese medical center between 1995 and 2008
AU - Fujita, Atsushi
AU - Hamada, Toshihisa
AU - Iwatsuki, Keiji
PY - 2011/6
Y1 - 2011/6
N2 - In 2008, a revised World Health Organization (WHO) system of hematological neoplasm classification was promulgated. Between January 1995 and December 2008, 133 new patients with cutaneous lymphomas were seen at the dermatology clinic of Okayama University Hospital. All patients were re-classified according to the revised WHO system. The incidence rates were analyzed and the survival was estimated. Of 133 patients, 106 (79.7%) had primary cutaneous lymphomas (PCLs) and 27 (20.3%) were skin invasion from extracutaneous origin of systemic lymphoma. Compared with several reports from western countries, "mature T-cell and NK-cell neoplasms" was frequent in this study (87% vs. 77 or 72%) because of the occurrence of adult T-cell leukemia/lymphoma (ATLL) and "extranodal NK/T cell lymphoma, nasal type", with less frequent occurrence of "mature B-cell neoplasms" (13% vs. 23 or 28%). Estimated survival of patients with mycosis fungoides was favorable (5-year survival rate 90.6%), but that of the patients with primary cutaneous anaplastic large cell lymphoma (C-ALCL) was extremely less favorable than previously reported (5-year survival rate of 47.4%).
AB - In 2008, a revised World Health Organization (WHO) system of hematological neoplasm classification was promulgated. Between January 1995 and December 2008, 133 new patients with cutaneous lymphomas were seen at the dermatology clinic of Okayama University Hospital. All patients were re-classified according to the revised WHO system. The incidence rates were analyzed and the survival was estimated. Of 133 patients, 106 (79.7%) had primary cutaneous lymphomas (PCLs) and 27 (20.3%) were skin invasion from extracutaneous origin of systemic lymphoma. Compared with several reports from western countries, "mature T-cell and NK-cell neoplasms" was frequent in this study (87% vs. 77 or 72%) because of the occurrence of adult T-cell leukemia/lymphoma (ATLL) and "extranodal NK/T cell lymphoma, nasal type", with less frequent occurrence of "mature B-cell neoplasms" (13% vs. 23 or 28%). Estimated survival of patients with mycosis fungoides was favorable (5-year survival rate 90.6%), but that of the patients with primary cutaneous anaplastic large cell lymphoma (C-ALCL) was extremely less favorable than previously reported (5-year survival rate of 47.4%).
KW - adult T-cell leukemia/lymphoma
KW - cutaneous lymphoma
KW - mycosis fungoides
KW - primary cutaneous anaplastic large cell lymphoma
UR - http://www.scopus.com/inward/record.url?scp=79957905206&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79957905206&partnerID=8YFLogxK
U2 - 10.1111/j.1346-8138.2010.01049.x
DO - 10.1111/j.1346-8138.2010.01049.x
M3 - Article
C2 - 21352297
AN - SCOPUS:79957905206
VL - 38
SP - 524
EP - 530
JO - Journal of Dermatology
JF - Journal of Dermatology
SN - 0385-2407
IS - 6
ER -