Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical

Yoshimi Sueishi, Risako Nii, Naru Kakizaki

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Resveratrol (RSV) analogues have attracted much attention because of the expected health functions including antioxidant activities. We have carried out a quantitative determination of the scavenging abilities of six trans-RSV analogues against various reactive oxygen species and methyl radical (hydroxyl radical, superoxide, alkoxyl radical, peroxyl radical, methyl radical, and singlet oxygen). RSV analogues are in general more potent scavenger than the parent RSV. Furthermore, piceatannol (PIC) having two OH groups in the ortho position of resveratrol was found to show 11 times higher scavenging ability against peroxyl radical than parent resveratrol. With the aid of previous theoretical studies, the enhanced antioxidant ability was interpreted based on the effects of substituent that modifies the original resveratrol structure and function.

Original languageEnglish
Pages (from-to)5203-5206
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume27
Issue number23
DOIs
Publication statusPublished - Dec 1 2017

Fingerprint

Scavenging
Reactive Oxygen Species
Antioxidants
Singlet Oxygen
methyl radical
3,3',4,5'-tetrahydroxystilbene
resveratrol
Superoxides
Hydroxyl Radical
Theoretical Models
Health

Keywords

  • Antioxidant ability
  • ESR spin-trapping
  • Multiple radical scavenging
  • Resveratrol
  • Resveratrol analogues

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

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abstract = "Resveratrol (RSV) analogues have attracted much attention because of the expected health functions including antioxidant activities. We have carried out a quantitative determination of the scavenging abilities of six trans-RSV analogues against various reactive oxygen species and methyl radical (hydroxyl radical, superoxide, alkoxyl radical, peroxyl radical, methyl radical, and singlet oxygen). RSV analogues are in general more potent scavenger than the parent RSV. Furthermore, piceatannol (PIC) having two OH groups in the ortho position of resveratrol was found to show 11 times higher scavenging ability against peroxyl radical than parent resveratrol. With the aid of previous theoretical studies, the enhanced antioxidant ability was interpreted based on the effects of substituent that modifies the original resveratrol structure and function.",
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