Restrictive ventilatory impairment is associated with poor outcome in patients with cT1aN0M0 peripheral squamous cell carcinoma of the lung

Hiroyuki Tao, Junichi Sou, Hiromasa Yamamoto, Toshiya Fujiwara, Tsuyoshi Ueno, Makio Hayama, Mikio Okazaki, Ryujiro Sugimoto, Motohiro Yamashita, Yoshifumi Sano, Kazunori Okabe, Motoki Matsuura, Kazuhiko Kataoka, Shigeharu Moriyama, Shinichi Toyooka, Shinichiro Miyoshi

Research output: Contribution to journalArticle

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Abstract

Background: Patients with squamous cell carcinoma (SqCC) of the lung sometimes have a comorbid pulmonary disease such as pulmonary emphysema or an interstitial lung disease (ILD), both of which negatively affect patient outcome. The aim of this study was to determine the outcome of patients in a multicenter database who underwent surgery for cT1aN0M0 peripheral SqCC lung cancer. Methods: The medical records of a total of 228 eligible patients from seven institutions were reviewed to evaluate the impact of concomitant impaired pulmonary function and other clinicopathological factors on overall survival (OS) and relapse-free survival (RFS). Results: Six patients with positive or unclear tumor margins were excluded. Of the 222 remaining study patients, 42 (18.9%) and 97 (43.7%) patients were found to have coexisting restrictive or obstructive ventilatory impairment, respectively. Over a median follow-up period of 30.6 months, the 5-year OS and RFS were 69.0% and 62.6%, respectively. By multivariate analysis, ILDs identified on high-resolution computed tomography (HRCT), pulmonary function test results indicating a restrictive ventilatory impairment, and wedge resection were found to be independent risk factors for poor OS. An increased level of serum squamous cell carcinoma antigen (SCC-Ag) ( > 1.5 ng/mL) and the same risk factors for poor OS were independent risk factors for recurrence. Among patients who underwent anatomical lung resection (lobectomy and segmentectomy, n=173), a restrictive ventilatory impairment was an independent risk factor for poor OS, and increased serum SCC-Ag level, ILDs on HRCT, and restrictive ventilatory impairment were independent risk factors for poor RFS by multivariate analysis. Factors such as visceral pleural invasion, and lymphatic or vascular invasion were not significantly associated with outcome. Conclusions: A restrictive ventilatory impairment negatively affects the outcome of patients with cT1aN0M0 peripheral SqCC lung cancer.

Original languageEnglish
Pages (from-to)4325-4335
Number of pages11
JournalJournal of Thoracic Disease
Volume9
Issue number11
DOIs
Publication statusPublished - Nov 1 2017

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Squamous Cell Carcinoma
Lung
Survival
Recurrence
Lung Neoplasms
Multivariate Analysis
Tomography
Pulmonary Emphysema
Segmental Mastectomy
Respiratory Function Tests
Interstitial Lung Diseases
Survival Analysis
Serum
Lung Diseases
Medical Records
Blood Vessels
Databases
Neoplasms

Keywords

  • Interstitial lung disease (ILD)
  • Restrictive ventilatory impairment
  • Squamous cell carcinoma of the lung

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Restrictive ventilatory impairment is associated with poor outcome in patients with cT1aN0M0 peripheral squamous cell carcinoma of the lung. / Tao, Hiroyuki; Sou, Junichi; Yamamoto, Hiromasa; Fujiwara, Toshiya; Ueno, Tsuyoshi; Hayama, Makio; Okazaki, Mikio; Sugimoto, Ryujiro; Yamashita, Motohiro; Sano, Yoshifumi; Okabe, Kazunori; Matsuura, Motoki; Kataoka, Kazuhiko; Moriyama, Shigeharu; Toyooka, Shinichi; Miyoshi, Shinichiro.

In: Journal of Thoracic Disease, Vol. 9, No. 11, 01.11.2017, p. 4325-4335.

Research output: Contribution to journalArticle

Tao, H, Sou, J, Yamamoto, H, Fujiwara, T, Ueno, T, Hayama, M, Okazaki, M, Sugimoto, R, Yamashita, M, Sano, Y, Okabe, K, Matsuura, M, Kataoka, K, Moriyama, S, Toyooka, S & Miyoshi, S 2017, 'Restrictive ventilatory impairment is associated with poor outcome in patients with cT1aN0M0 peripheral squamous cell carcinoma of the lung', Journal of Thoracic Disease, vol. 9, no. 11, pp. 4325-4335. https://doi.org/10.21037/jtd.2017.10.70
Tao, Hiroyuki ; Sou, Junichi ; Yamamoto, Hiromasa ; Fujiwara, Toshiya ; Ueno, Tsuyoshi ; Hayama, Makio ; Okazaki, Mikio ; Sugimoto, Ryujiro ; Yamashita, Motohiro ; Sano, Yoshifumi ; Okabe, Kazunori ; Matsuura, Motoki ; Kataoka, Kazuhiko ; Moriyama, Shigeharu ; Toyooka, Shinichi ; Miyoshi, Shinichiro. / Restrictive ventilatory impairment is associated with poor outcome in patients with cT1aN0M0 peripheral squamous cell carcinoma of the lung. In: Journal of Thoracic Disease. 2017 ; Vol. 9, No. 11. pp. 4325-4335.
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abstract = "Background: Patients with squamous cell carcinoma (SqCC) of the lung sometimes have a comorbid pulmonary disease such as pulmonary emphysema or an interstitial lung disease (ILD), both of which negatively affect patient outcome. The aim of this study was to determine the outcome of patients in a multicenter database who underwent surgery for cT1aN0M0 peripheral SqCC lung cancer. Methods: The medical records of a total of 228 eligible patients from seven institutions were reviewed to evaluate the impact of concomitant impaired pulmonary function and other clinicopathological factors on overall survival (OS) and relapse-free survival (RFS). Results: Six patients with positive or unclear tumor margins were excluded. Of the 222 remaining study patients, 42 (18.9{\%}) and 97 (43.7{\%}) patients were found to have coexisting restrictive or obstructive ventilatory impairment, respectively. Over a median follow-up period of 30.6 months, the 5-year OS and RFS were 69.0{\%} and 62.6{\%}, respectively. By multivariate analysis, ILDs identified on high-resolution computed tomography (HRCT), pulmonary function test results indicating a restrictive ventilatory impairment, and wedge resection were found to be independent risk factors for poor OS. An increased level of serum squamous cell carcinoma antigen (SCC-Ag) ( > 1.5 ng/mL) and the same risk factors for poor OS were independent risk factors for recurrence. Among patients who underwent anatomical lung resection (lobectomy and segmentectomy, n=173), a restrictive ventilatory impairment was an independent risk factor for poor OS, and increased serum SCC-Ag level, ILDs on HRCT, and restrictive ventilatory impairment were independent risk factors for poor RFS by multivariate analysis. Factors such as visceral pleural invasion, and lymphatic or vascular invasion were not significantly associated with outcome. Conclusions: A restrictive ventilatory impairment negatively affects the outcome of patients with cT1aN0M0 peripheral SqCC lung cancer.",
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T1 - Restrictive ventilatory impairment is associated with poor outcome in patients with cT1aN0M0 peripheral squamous cell carcinoma of the lung

AU - Tao, Hiroyuki

AU - Sou, Junichi

AU - Yamamoto, Hiromasa

AU - Fujiwara, Toshiya

AU - Ueno, Tsuyoshi

AU - Hayama, Makio

AU - Okazaki, Mikio

AU - Sugimoto, Ryujiro

AU - Yamashita, Motohiro

AU - Sano, Yoshifumi

AU - Okabe, Kazunori

AU - Matsuura, Motoki

AU - Kataoka, Kazuhiko

AU - Moriyama, Shigeharu

AU - Toyooka, Shinichi

AU - Miyoshi, Shinichiro

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Background: Patients with squamous cell carcinoma (SqCC) of the lung sometimes have a comorbid pulmonary disease such as pulmonary emphysema or an interstitial lung disease (ILD), both of which negatively affect patient outcome. The aim of this study was to determine the outcome of patients in a multicenter database who underwent surgery for cT1aN0M0 peripheral SqCC lung cancer. Methods: The medical records of a total of 228 eligible patients from seven institutions were reviewed to evaluate the impact of concomitant impaired pulmonary function and other clinicopathological factors on overall survival (OS) and relapse-free survival (RFS). Results: Six patients with positive or unclear tumor margins were excluded. Of the 222 remaining study patients, 42 (18.9%) and 97 (43.7%) patients were found to have coexisting restrictive or obstructive ventilatory impairment, respectively. Over a median follow-up period of 30.6 months, the 5-year OS and RFS were 69.0% and 62.6%, respectively. By multivariate analysis, ILDs identified on high-resolution computed tomography (HRCT), pulmonary function test results indicating a restrictive ventilatory impairment, and wedge resection were found to be independent risk factors for poor OS. An increased level of serum squamous cell carcinoma antigen (SCC-Ag) ( > 1.5 ng/mL) and the same risk factors for poor OS were independent risk factors for recurrence. Among patients who underwent anatomical lung resection (lobectomy and segmentectomy, n=173), a restrictive ventilatory impairment was an independent risk factor for poor OS, and increased serum SCC-Ag level, ILDs on HRCT, and restrictive ventilatory impairment were independent risk factors for poor RFS by multivariate analysis. Factors such as visceral pleural invasion, and lymphatic or vascular invasion were not significantly associated with outcome. Conclusions: A restrictive ventilatory impairment negatively affects the outcome of patients with cT1aN0M0 peripheral SqCC lung cancer.

AB - Background: Patients with squamous cell carcinoma (SqCC) of the lung sometimes have a comorbid pulmonary disease such as pulmonary emphysema or an interstitial lung disease (ILD), both of which negatively affect patient outcome. The aim of this study was to determine the outcome of patients in a multicenter database who underwent surgery for cT1aN0M0 peripheral SqCC lung cancer. Methods: The medical records of a total of 228 eligible patients from seven institutions were reviewed to evaluate the impact of concomitant impaired pulmonary function and other clinicopathological factors on overall survival (OS) and relapse-free survival (RFS). Results: Six patients with positive or unclear tumor margins were excluded. Of the 222 remaining study patients, 42 (18.9%) and 97 (43.7%) patients were found to have coexisting restrictive or obstructive ventilatory impairment, respectively. Over a median follow-up period of 30.6 months, the 5-year OS and RFS were 69.0% and 62.6%, respectively. By multivariate analysis, ILDs identified on high-resolution computed tomography (HRCT), pulmonary function test results indicating a restrictive ventilatory impairment, and wedge resection were found to be independent risk factors for poor OS. An increased level of serum squamous cell carcinoma antigen (SCC-Ag) ( > 1.5 ng/mL) and the same risk factors for poor OS were independent risk factors for recurrence. Among patients who underwent anatomical lung resection (lobectomy and segmentectomy, n=173), a restrictive ventilatory impairment was an independent risk factor for poor OS, and increased serum SCC-Ag level, ILDs on HRCT, and restrictive ventilatory impairment were independent risk factors for poor RFS by multivariate analysis. Factors such as visceral pleural invasion, and lymphatic or vascular invasion were not significantly associated with outcome. Conclusions: A restrictive ventilatory impairment negatively affects the outcome of patients with cT1aN0M0 peripheral SqCC lung cancer.

KW - Interstitial lung disease (ILD)

KW - Restrictive ventilatory impairment

KW - Squamous cell carcinoma of the lung

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