Restoration of immunocyte functions by thymosin α1 in cyclophosphamide-induced immunodeficient mice

H. Ohmori, M. Kamo, K. Yamakoshi, M. Hayakawa, M. Nitta, M. Hikida, Naoki Kanayama

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Thymosin α1 (Tα1) is an oligopeptide hormone originally isolated from the thymus gland, and has been reported to have stimulating effects on the differentiation of T cells and NK cells. These immunostimulating properties have been considered to be useful for improving immune disorders associated with various diseases including cancer, AIDS and hepatitis. Here, we characterized immunostimulating properties of Tα1 in experimental immunodeficiency of mice that was induced by the administration of cyclophosphamide (CY). Repeated injection of 30-300 μg/kg/day of Tα1 after CY-treatment significantly accelerated the restoration of the reduced number of CD4+CD8+ T cells in the thymus. Tα1 administration was effective in restoring the suppressed activities of helper T cells and cytotoxic T cells in CY-treated mice. Tα1 also had stimulating effects on reduced activity of lymphokine-activated killer cells in CY-treated mice. These results indicate that Tα1 is stimulatory for both humoral and cellular immune responses, thus providing the immunological basis for the clinical benefit of this compound.

Original languageEnglish
Pages (from-to)75-82
Number of pages8
JournalImmunopharmacology and Immunotoxicology
Volume23
Issue number1
DOIs
Publication statusPublished - 2001

Fingerprint

Thymosin
Cyclophosphamide
Restoration
T-cells
Thymus
T-Lymphocytes
Thymus Gland
Lymphokine-Activated Killer Cells
Oligopeptides
Lymphokines
Immune System Diseases
Humoral Immunity
Helper-Inducer T-Lymphocytes
Cellular Immunity
Natural Killer Cells
Hepatitis
Acquired Immunodeficiency Syndrome
Hormones
Injections
Neoplasms

ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Restoration of immunocyte functions by thymosin α1 in cyclophosphamide-induced immunodeficient mice. / Ohmori, H.; Kamo, M.; Yamakoshi, K.; Hayakawa, M.; Nitta, M.; Hikida, M.; Kanayama, Naoki.

In: Immunopharmacology and Immunotoxicology, Vol. 23, No. 1, 2001, p. 75-82.

Research output: Contribution to journalArticle

Ohmori, H. ; Kamo, M. ; Yamakoshi, K. ; Hayakawa, M. ; Nitta, M. ; Hikida, M. ; Kanayama, Naoki. / Restoration of immunocyte functions by thymosin α1 in cyclophosphamide-induced immunodeficient mice. In: Immunopharmacology and Immunotoxicology. 2001 ; Vol. 23, No. 1. pp. 75-82.
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