Abstract
Thymosin α1 (Tα1) is an oligopeptide hormone originally isolated from the thymus gland, and has been reported to have stimulating effects on the differentiation of T cells and NK cells. These immunostimulating properties have been considered to be useful for improving immune disorders associated with various diseases including cancer, AIDS and hepatitis. Here, we characterized immunostimulating properties of Tα1 in experimental immunodeficiency of mice that was induced by the administration of cyclophosphamide (CY). Repeated injection of 30-300 μg/kg/day of Tα1 after CY-treatment significantly accelerated the restoration of the reduced number of CD4+CD8+ T cells in the thymus. Tα1 administration was effective in restoring the suppressed activities of helper T cells and cytotoxic T cells in CY-treated mice. Tα1 also had stimulating effects on reduced activity of lymphokine-activated killer cells in CY-treated mice. These results indicate that Tα1 is stimulatory for both humoral and cellular immune responses, thus providing the immunological basis for the clinical benefit of this compound.
| Original language | English |
|---|---|
| Pages (from-to) | 75-82 |
| Number of pages | 8 |
| Journal | Immunopharmacology and Immunotoxicology |
| Volume | 23 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2001 |
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ASJC Scopus subject areas
- Immunology
- Pharmacology
- Toxicology
- Health, Toxicology and Mutagenesis
Cite this
Restoration of immunocyte functions by thymosin α1 in cyclophosphamide-induced immunodeficient mice. / Ohmori, H.; Kamo, M.; Yamakoshi, K.; Hayakawa, M.; Nitta, M.; Hikida, M.; Kanayama, Naoki.
In: Immunopharmacology and Immunotoxicology, Vol. 23, No. 1, 2001, p. 75-82.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Restoration of immunocyte functions by thymosin α1 in cyclophosphamide-induced immunodeficient mice
AU - Ohmori, H.
AU - Kamo, M.
AU - Yamakoshi, K.
AU - Hayakawa, M.
AU - Nitta, M.
AU - Hikida, M.
AU - Kanayama, Naoki
PY - 2001
Y1 - 2001
N2 - Thymosin α1 (Tα1) is an oligopeptide hormone originally isolated from the thymus gland, and has been reported to have stimulating effects on the differentiation of T cells and NK cells. These immunostimulating properties have been considered to be useful for improving immune disorders associated with various diseases including cancer, AIDS and hepatitis. Here, we characterized immunostimulating properties of Tα1 in experimental immunodeficiency of mice that was induced by the administration of cyclophosphamide (CY). Repeated injection of 30-300 μg/kg/day of Tα1 after CY-treatment significantly accelerated the restoration of the reduced number of CD4+CD8+ T cells in the thymus. Tα1 administration was effective in restoring the suppressed activities of helper T cells and cytotoxic T cells in CY-treated mice. Tα1 also had stimulating effects on reduced activity of lymphokine-activated killer cells in CY-treated mice. These results indicate that Tα1 is stimulatory for both humoral and cellular immune responses, thus providing the immunological basis for the clinical benefit of this compound.
AB - Thymosin α1 (Tα1) is an oligopeptide hormone originally isolated from the thymus gland, and has been reported to have stimulating effects on the differentiation of T cells and NK cells. These immunostimulating properties have been considered to be useful for improving immune disorders associated with various diseases including cancer, AIDS and hepatitis. Here, we characterized immunostimulating properties of Tα1 in experimental immunodeficiency of mice that was induced by the administration of cyclophosphamide (CY). Repeated injection of 30-300 μg/kg/day of Tα1 after CY-treatment significantly accelerated the restoration of the reduced number of CD4+CD8+ T cells in the thymus. Tα1 administration was effective in restoring the suppressed activities of helper T cells and cytotoxic T cells in CY-treated mice. Tα1 also had stimulating effects on reduced activity of lymphokine-activated killer cells in CY-treated mice. These results indicate that Tα1 is stimulatory for both humoral and cellular immune responses, thus providing the immunological basis for the clinical benefit of this compound.
UR - http://www.scopus.com/inward/record.url?scp=0035070363&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035070363&partnerID=8YFLogxK
U2 - 10.1081/IPH-100102569
DO - 10.1081/IPH-100102569
M3 - Article
C2 - 11322651
AN - SCOPUS:0035070363
VL - 23
SP - 75
EP - 82
JO - Immunopharmacology and Immunotoxicology
JF - Immunopharmacology and Immunotoxicology
SN - 0892-3973
IS - 1
ER -