TY - JOUR
T1 - Restoration of effectiveness of β-lactams on methicillin-resistant Staphylococcus aureus by tellimagrandin I from rose red
AU - Shiota, Sumiko
AU - Shimizu, Masato
AU - Mizusima, Tohru
AU - Ito, Hideyuki
AU - Hatano, Tsutomu
AU - Yoshida, Takashi
AU - Tsuchiya, Tomofusa
PY - 2000/4/15
Y1 - 2000/4/15
N2 - We found that extract from petals of Rosa canina L. (rose red) strikingly reduced the minimum inhibitory concentration of β-lactams in methicillin-resistant Staphylococcus aureus. We isolated two compounds that reduced the minimum inhibitory concentrations of β-lactams from the extract, tellimagrandin I and rugosin B. Tellimagrandin I was very effective regarding the reduction of the minimum inhibitory concentration, and rugosin B showed some effect. Tellimagrandin I showed a weak bactericidal action when added together with oxacillin. Judging from the fractional inhibitory concentration index, the effect of tellimagrandin I and oxacillin was synergistic. Tellimagrandin I also significantly reduced the minimum inhibitory concentration of tetracycline in some strains of methicillin-resistant Staphylococcus aureus. Copyright (C) 2000 Federation of European Microbiological Societies.
AB - We found that extract from petals of Rosa canina L. (rose red) strikingly reduced the minimum inhibitory concentration of β-lactams in methicillin-resistant Staphylococcus aureus. We isolated two compounds that reduced the minimum inhibitory concentrations of β-lactams from the extract, tellimagrandin I and rugosin B. Tellimagrandin I was very effective regarding the reduction of the minimum inhibitory concentration, and rugosin B showed some effect. Tellimagrandin I showed a weak bactericidal action when added together with oxacillin. Judging from the fractional inhibitory concentration index, the effect of tellimagrandin I and oxacillin was synergistic. Tellimagrandin I also significantly reduced the minimum inhibitory concentration of tetracycline in some strains of methicillin-resistant Staphylococcus aureus. Copyright (C) 2000 Federation of European Microbiological Societies.
KW - Methicillin-resistant Staphylococcus aureus
KW - Reduction in minimum inhibitory concentration
KW - Susceptibility to β-lactams
KW - Tellimagrandin I
UR - http://www.scopus.com/inward/record.url?scp=0034656247&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034656247&partnerID=8YFLogxK
U2 - 10.1016/S0378-1097(00)00086-0
DO - 10.1016/S0378-1097(00)00086-0
M3 - Article
C2 - 10754237
AN - SCOPUS:0034656247
SN - 0378-1097
VL - 185
SP - 135
EP - 138
JO - FEMS Microbiology Letters
JF - FEMS Microbiology Letters
IS - 2
ER -