Restoration of effectiveness of β-lactams on methicillin-resistant Staphylococcus aureus by tellimagrandin I from rose red

Sumiko Shiota, Masato Shimizu, Tohru Mizusima, Hideyuki Ito, Tsutomu Hatano, Takashi Yoshida, Tomofusa Tsuchiya

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

We found that extract from petals of Rosa canina L. (rose red) strikingly reduced the minimum inhibitory concentration of β-lactams in methicillin-resistant Staphylococcus aureus. We isolated two compounds that reduced the minimum inhibitory concentrations of β-lactams from the extract, tellimagrandin I and rugosin B. Tellimagrandin I was very effective regarding the reduction of the minimum inhibitory concentration, and rugosin B showed some effect. Tellimagrandin I showed a weak bactericidal action when added together with oxacillin. Judging from the fractional inhibitory concentration index, the effect of tellimagrandin I and oxacillin was synergistic. Tellimagrandin I also significantly reduced the minimum inhibitory concentration of tetracycline in some strains of methicillin-resistant Staphylococcus aureus. Copyright (C) 2000 Federation of European Microbiological Societies.

Original languageEnglish
Pages (from-to)135-138
Number of pages4
JournalFEMS Microbiology Letters
Volume185
Issue number2
DOIs
Publication statusPublished - Apr 15 2000

Keywords

  • Methicillin-resistant Staphylococcus aureus
  • Reduction in minimum inhibitory concentration
  • Susceptibility to β-lactams
  • Tellimagrandin I

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

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