Responses of the hypothalamic-pituitary-adrenal axis and pain threshold changes in the orofacial region upon cold pressor stimulation in normal volunteers

Koji Suzuki, Kenji Maekawa, Hajime Minakuchi, Hirofumi Yatani, Glenn T. Clark, Yoshizo Matsuka, Takuo Kuboki

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Aim: This study focused on the relationship between the HPA axis function and the heat pain threshold in the orofacial region upon cold pressor (CP) stimulation. Methods: Ten healthy male individuals participated in this study. CP stimulation was applied to each participant, and their peripheral blood was collected 5 min before, during and 5, 15, 30, 45, 60 min after receiving CP. In addition, 5 of those 10 participants were selected at random and they experienced a mock CP trial on different days. The heat pain thresholds on the facial skin about 10 mm anterior to the right external auditory canal (trigeminal V2 region) in each subject were simultaneously recorded 5 min before and 5, 30, 60 min after CP stimulation. The blood pressure and heart rate were continuously monitored throughout the course of the CP and mock trials using an electric blood pressure meter. Results: Significant increases in the plasma concentration of cortisol, β-endorphin and ACTH were induced by CP stimulation, while no significant increases were observed under the mock trial conditions. The blood pressure and heart rate showed concomitant increases during CP stimulation. In addition, the heat pain threshold in the orofacial region significantly increased after receiving CP stimulation. These results suggest that CP stimulation activated the HPA axis thereby increasing the heat pain threshold in the orofacial region in healthy individuals. Conclusions: This observed pain threshold increase might be due to the activation of an endogenous opioid system, such as increase in the circulating β-endorphin levels.

Original languageEnglish
Pages (from-to)797-802
Number of pages6
JournalArchives of Oral Biology
Volume52
Issue number8
DOIs
Publication statusPublished - Aug 2007

Fingerprint

Pain Threshold
Healthy Volunteers
Hot Temperature
Endorphins
Blood Pressure
Heart Rate
Ear Canal
Adrenocorticotropic Hormone
Opioid Analgesics
Hydrocortisone
Skin

Keywords

  • β-Endorphin
  • Cold pressor
  • Heat pain threshold
  • HPA axis
  • Orofacial region

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Responses of the hypothalamic-pituitary-adrenal axis and pain threshold changes in the orofacial region upon cold pressor stimulation in normal volunteers. / Suzuki, Koji; Maekawa, Kenji; Minakuchi, Hajime; Yatani, Hirofumi; Clark, Glenn T.; Matsuka, Yoshizo; Kuboki, Takuo.

In: Archives of Oral Biology, Vol. 52, No. 8, 08.2007, p. 797-802.

Research output: Contribution to journalArticle

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