Reproductive risk in mating between two translocation carriers: Case report and review of the literature

K. Tsuji, K. Narahara, Y. Yokoyama, S. Ninomiya, S. Yonesawa, Y. Hiramatsu, H. Masaoka, N. Kudo, Y. Seino

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We conducted a study to determine the reproductive risk in a couple who were translocation carriers. This couple, who carried balanced reciprocal translocations, experienced habitual abortions. The wife had a karyotype of 46,XX,t(7;13)(p15.3;q12.3) and the husband of 46,XY,t(1;7)(p11.1;p11.1). Chromosome study of their fourth abortus demonstrated a chimera consisting of two cell lines with a 46,XY and a 46,XX,t(1;7)(p11.1;p11.1)pat, -13, + der(7)t(7;13)(p15.3;q12.3)mat, karyotype. A review of the literature indicates that the risk of having unbalanced live offspring or of spontaneous abortion/stillborns is similar in couples in whom both were translocation carriers and in couples in whom one individual was a translocation carrier. The apparent lack of increased reproductive failure may result from the selective disadvantage of aneusomic gametes at fertilization or very early spontaneous abortions of unbalanced conceptuses.

Original languageEnglish
Pages (from-to)524-528
Number of pages5
JournalAmerican Journal of Medical Genetics
Volume46
Issue number5
Publication statusPublished - 1993

Fingerprint

Spontaneous Abortion
Spouses
Karyotype
Habitual Abortion
Fertilization
Germ Cells
Chromosomes
Cell Line

Keywords

  • adjacent-2 segregation
  • alternative segregation
  • habitual abortion
  • mating between translocation carriers
  • reproductive failure

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Tsuji, K., Narahara, K., Yokoyama, Y., Ninomiya, S., Yonesawa, S., Hiramatsu, Y., ... Seino, Y. (1993). Reproductive risk in mating between two translocation carriers: Case report and review of the literature. American Journal of Medical Genetics, 46(5), 524-528.

Reproductive risk in mating between two translocation carriers : Case report and review of the literature. / Tsuji, K.; Narahara, K.; Yokoyama, Y.; Ninomiya, S.; Yonesawa, S.; Hiramatsu, Y.; Masaoka, H.; Kudo, N.; Seino, Y.

In: American Journal of Medical Genetics, Vol. 46, No. 5, 1993, p. 524-528.

Research output: Contribution to journalArticle

Tsuji, K, Narahara, K, Yokoyama, Y, Ninomiya, S, Yonesawa, S, Hiramatsu, Y, Masaoka, H, Kudo, N & Seino, Y 1993, 'Reproductive risk in mating between two translocation carriers: Case report and review of the literature', American Journal of Medical Genetics, vol. 46, no. 5, pp. 524-528.
Tsuji K, Narahara K, Yokoyama Y, Ninomiya S, Yonesawa S, Hiramatsu Y et al. Reproductive risk in mating between two translocation carriers: Case report and review of the literature. American Journal of Medical Genetics. 1993;46(5):524-528.
Tsuji, K. ; Narahara, K. ; Yokoyama, Y. ; Ninomiya, S. ; Yonesawa, S. ; Hiramatsu, Y. ; Masaoka, H. ; Kudo, N. ; Seino, Y. / Reproductive risk in mating between two translocation carriers : Case report and review of the literature. In: American Journal of Medical Genetics. 1993 ; Vol. 46, No. 5. pp. 524-528.
@article{4a21f0b9ad2344b2872152bda453a251,
title = "Reproductive risk in mating between two translocation carriers: Case report and review of the literature",
abstract = "We conducted a study to determine the reproductive risk in a couple who were translocation carriers. This couple, who carried balanced reciprocal translocations, experienced habitual abortions. The wife had a karyotype of 46,XX,t(7;13)(p15.3;q12.3) and the husband of 46,XY,t(1;7)(p11.1;p11.1). Chromosome study of their fourth abortus demonstrated a chimera consisting of two cell lines with a 46,XY and a 46,XX,t(1;7)(p11.1;p11.1)pat, -13, + der(7)t(7;13)(p15.3;q12.3)mat, karyotype. A review of the literature indicates that the risk of having unbalanced live offspring or of spontaneous abortion/stillborns is similar in couples in whom both were translocation carriers and in couples in whom one individual was a translocation carrier. The apparent lack of increased reproductive failure may result from the selective disadvantage of aneusomic gametes at fertilization or very early spontaneous abortions of unbalanced conceptuses.",
keywords = "adjacent-2 segregation, alternative segregation, habitual abortion, mating between translocation carriers, reproductive failure",
author = "K. Tsuji and K. Narahara and Y. Yokoyama and S. Ninomiya and S. Yonesawa and Y. Hiramatsu and H. Masaoka and N. Kudo and Y. Seino",
year = "1993",
language = "English",
volume = "46",
pages = "524--528",
journal = "American Journal of Medical Genetics",
issn = "0148-7299",
publisher = "Wiley-Liss Inc.",
number = "5",

}

TY - JOUR

T1 - Reproductive risk in mating between two translocation carriers

T2 - Case report and review of the literature

AU - Tsuji, K.

AU - Narahara, K.

AU - Yokoyama, Y.

AU - Ninomiya, S.

AU - Yonesawa, S.

AU - Hiramatsu, Y.

AU - Masaoka, H.

AU - Kudo, N.

AU - Seino, Y.

PY - 1993

Y1 - 1993

N2 - We conducted a study to determine the reproductive risk in a couple who were translocation carriers. This couple, who carried balanced reciprocal translocations, experienced habitual abortions. The wife had a karyotype of 46,XX,t(7;13)(p15.3;q12.3) and the husband of 46,XY,t(1;7)(p11.1;p11.1). Chromosome study of their fourth abortus demonstrated a chimera consisting of two cell lines with a 46,XY and a 46,XX,t(1;7)(p11.1;p11.1)pat, -13, + der(7)t(7;13)(p15.3;q12.3)mat, karyotype. A review of the literature indicates that the risk of having unbalanced live offspring or of spontaneous abortion/stillborns is similar in couples in whom both were translocation carriers and in couples in whom one individual was a translocation carrier. The apparent lack of increased reproductive failure may result from the selective disadvantage of aneusomic gametes at fertilization or very early spontaneous abortions of unbalanced conceptuses.

AB - We conducted a study to determine the reproductive risk in a couple who were translocation carriers. This couple, who carried balanced reciprocal translocations, experienced habitual abortions. The wife had a karyotype of 46,XX,t(7;13)(p15.3;q12.3) and the husband of 46,XY,t(1;7)(p11.1;p11.1). Chromosome study of their fourth abortus demonstrated a chimera consisting of two cell lines with a 46,XY and a 46,XX,t(1;7)(p11.1;p11.1)pat, -13, + der(7)t(7;13)(p15.3;q12.3)mat, karyotype. A review of the literature indicates that the risk of having unbalanced live offspring or of spontaneous abortion/stillborns is similar in couples in whom both were translocation carriers and in couples in whom one individual was a translocation carrier. The apparent lack of increased reproductive failure may result from the selective disadvantage of aneusomic gametes at fertilization or very early spontaneous abortions of unbalanced conceptuses.

KW - adjacent-2 segregation

KW - alternative segregation

KW - habitual abortion

KW - mating between translocation carriers

KW - reproductive failure

UR - http://www.scopus.com/inward/record.url?scp=0027272111&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027272111&partnerID=8YFLogxK

M3 - Article

C2 - 8322814

AN - SCOPUS:0027272111

VL - 46

SP - 524

EP - 528

JO - American Journal of Medical Genetics

JF - American Journal of Medical Genetics

SN - 0148-7299

IS - 5

ER -