Reproductive and developmental toxicity screening test of 3-cyanopyridine in rats

Mika Takahashi, Kaoru Yabe, Hina Kato, Tomoko Kawamura, Mariko Matsumoto, Mutsuko Hirata-Koizumi, Atsushi Ono, Akihiko Hirose

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Crl:CD(SD)rats were given 3-cyanopyridine by gavage at 0, 5, 30 or 180. mg/kg/day. Males were dosed for 42 days beginning 14 days before mating, and females for 40-53 days beginning 14 days before mating to day 3 of lactation, including throughout the mating and gestation periods. General toxicity, mainly liver damage, was observed in males at ≥30. mg/kg/day and in females at ≥5. mg/kg/day. Sertoli cell vacuolation was observed at 180. mg/kg/day, and spermatocyte damages were observed at ≥30. mg/kg/day. Effects on estrous cycles, corpora lutea and implantations, and unsuccessfully mated females, despite additional mating, were observed at 180. mg/kg/day. Delayed initiation of delivery, dystocia, and deaths or moribundities of pregnant females were observed at 180. mg/kg/day, and only two pregnant rats delivered live pups at that dose. The NOAEL for reproductive/developmental toxicity was concluded to be 30 mg/kg/day.

Original languageEnglish
Pages (from-to)7-16
Number of pages10
JournalReproductive Toxicology
Volume35
Issue number1
DOIs
Publication statusPublished - Jan 1 2013
Externally publishedYes

Keywords

  • 3-Cyanopyridine
  • Rat
  • Reproductive and developmental toxicity
  • Testicular toxicity

ASJC Scopus subject areas

  • Toxicology

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  • Cite this

    Takahashi, M., Yabe, K., Kato, H., Kawamura, T., Matsumoto, M., Hirata-Koizumi, M., Ono, A., & Hirose, A. (2013). Reproductive and developmental toxicity screening test of 3-cyanopyridine in rats. Reproductive Toxicology, 35(1), 7-16. https://doi.org/10.1016/j.reprotox.2012.10.014