Abstract
We previously developed an alternative method for estimating the brain perfusion index (BPI) using technetium-99m compounds and spectral analysis (SA) for quantification of cerebral blood flow (CBF). In this study, we investigated the reproducibility of the BPI values obtained by SA (BPIS) using a double injection of technetium-99m ethyl cysteinate dimer without any intervention, and compared it with that of the BPI values obtained by graphical analysis (BPIG). The BPIS values in the first (x) and second sessions (y) correlated closely (y=0.921x+0.036; r=0.962; n=64; s.e.e.=0.058 min-1). Although the BPIG values in the first (x) and second sessions (y) also correlated (y=0.942x+0.040; r=0.916; n=64; s.e.e.=0.061 min-1), the correlation coefficient for BPIS was significantly higher than that for BPIG. The reproducibility was dependent on the injection dose ratio of the second session to the first (R). The difference in BPI between the first and second sessions tended to be smaller when 1.5S is satisfactory and that it can be applied to two sequential measurements of CBF using a double injection of 99mTc compounds. When applying our method to such measurements, it is recommended that R is taken as approximately 2.0.
| Original language | English |
|---|---|
| Pages (from-to) | 1640-1646 |
| Number of pages | 7 |
| Journal | European Journal Of Nuclear Medicine |
| Volume | 28 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2001 |
| Externally published | Yes |
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Keywords
- Brain perfusion index
- Graphical analysis
- Reproducibility
- Spectral analysis
- Technetium-99m ECD
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Reproducibility of the brain perfusion index for measuring cerebral blood flow using technetium-99m compounds. / Murase, Kenya; Fujioka, Hiroyoshi; Inoue, Takeshi; Ishimaru, Yoshihiro; Akamune, Akihisa; Yamamoto, Yuji; Mochizuki, Teruhito; Ikezoe, Junpei.
In: European Journal Of Nuclear Medicine, Vol. 28, No. 11, 2001, p. 1640-1646.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reproducibility of the brain perfusion index for measuring cerebral blood flow using technetium-99m compounds
AU - Murase, Kenya
AU - Fujioka, Hiroyoshi
AU - Inoue, Takeshi
AU - Ishimaru, Yoshihiro
AU - Akamune, Akihisa
AU - Yamamoto, Yuji
AU - Mochizuki, Teruhito
AU - Ikezoe, Junpei
PY - 2001
Y1 - 2001
N2 - We previously developed an alternative method for estimating the brain perfusion index (BPI) using technetium-99m compounds and spectral analysis (SA) for quantification of cerebral blood flow (CBF). In this study, we investigated the reproducibility of the BPI values obtained by SA (BPIS) using a double injection of technetium-99m ethyl cysteinate dimer without any intervention, and compared it with that of the BPI values obtained by graphical analysis (BPIG). The BPIS values in the first (x) and second sessions (y) correlated closely (y=0.921x+0.036; r=0.962; n=64; s.e.e.=0.058 min-1). Although the BPIG values in the first (x) and second sessions (y) also correlated (y=0.942x+0.040; r=0.916; n=64; s.e.e.=0.061 min-1), the correlation coefficient for BPIS was significantly higher than that for BPIG. The reproducibility was dependent on the injection dose ratio of the second session to the first (R). The difference in BPI between the first and second sessions tended to be smaller when 1.5S is satisfactory and that it can be applied to two sequential measurements of CBF using a double injection of 99mTc compounds. When applying our method to such measurements, it is recommended that R is taken as approximately 2.0.
AB - We previously developed an alternative method for estimating the brain perfusion index (BPI) using technetium-99m compounds and spectral analysis (SA) for quantification of cerebral blood flow (CBF). In this study, we investigated the reproducibility of the BPI values obtained by SA (BPIS) using a double injection of technetium-99m ethyl cysteinate dimer without any intervention, and compared it with that of the BPI values obtained by graphical analysis (BPIG). The BPIS values in the first (x) and second sessions (y) correlated closely (y=0.921x+0.036; r=0.962; n=64; s.e.e.=0.058 min-1). Although the BPIG values in the first (x) and second sessions (y) also correlated (y=0.942x+0.040; r=0.916; n=64; s.e.e.=0.061 min-1), the correlation coefficient for BPIS was significantly higher than that for BPIG. The reproducibility was dependent on the injection dose ratio of the second session to the first (R). The difference in BPI between the first and second sessions tended to be smaller when 1.5S is satisfactory and that it can be applied to two sequential measurements of CBF using a double injection of 99mTc compounds. When applying our method to such measurements, it is recommended that R is taken as approximately 2.0.
KW - Brain perfusion index
KW - Graphical analysis
KW - Reproducibility
KW - Spectral analysis
KW - Technetium-99m ECD
UR - http://www.scopus.com/inward/record.url?scp=0034759758&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034759758&partnerID=8YFLogxK
U2 - 10.1007/s002590100616
DO - 10.1007/s002590100616
M3 - Article
C2 - 11702105
AN - SCOPUS:0034759758
VL - 28
SP - 1640
EP - 1646
JO - European Journal of Nuclear Medicine and Molecular Imaging
JF - European Journal of Nuclear Medicine and Molecular Imaging
SN - 1619-7070
IS - 11
ER -