Report of a study using phantom materials, and clinical experience with simultaneous radio-hyperthermotherapy.

Masahiro Kuroda, K. Inamura, S. Tahara, S. Mimura, Y. Mikami, S. Kawasaki, Y. Hiraki

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Simultaneous radiohyperthermotherapy (SRH) is a combined hyperthermia-radiation therapy in which irradiation is given during heating. Mutual interference between the high energy radiotherapy system (Toshiba LMR-15A) and the 13.56 MHz capacitive heating system (Omron HEH-500C) was tested with phantom materials prior to a clinical trial with SRH. The energy and flatness of irradiation were not affected by the heating system within the range of clinical use. The high energy radiotherapy system did not affect the increase or distribution of temperature during simultaneous treatment. The results of this phantom study indicated that these apparatuses would not produce clinically significant mutual interference during SRH. A clinical trial was performed on a 57-year-old woman with postoperative recurrence of rectal cancer. This is the first reported clinical case treated with true SRH in which external irradiation was administered during mid capacitive heating. Twelve SRH treatments were performed on the recurrent lesion at a frequency of twice a week for six weeks using the apparatuses described above. There was a significant reduction in pain after treatment. The tumor marker carcinoembryonic antigen (CEA) level decreased after treatment. On CT images taken after treatment, the tumor site became a low density area which indicated necrosis. There were no side effects. These results suggest that further clinical study of SRH should be performed to clarify its advantages.

Original languageEnglish
Pages (from-to)417-426
Number of pages10
JournalActa Medica Okayama
Volume46
Issue number6
Publication statusPublished - Dec 1992

Fingerprint

Radio
Radiotherapy
Heating
High-Energy Radiotherapy
Irradiation
Clinical Trials
Carcinoembryonic Antigen
Therapeutics
Tumor Biomarkers
Differentiation Antigens
Tumors
Neoplasm Antigens
Rectal Neoplasms
Fever
Necrosis
Recurrence
Pain
Temperature
Neoplasms

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Kuroda, M., Inamura, K., Tahara, S., Mimura, S., Mikami, Y., Kawasaki, S., & Hiraki, Y. (1992). Report of a study using phantom materials, and clinical experience with simultaneous radio-hyperthermotherapy. Acta Medica Okayama, 46(6), 417-426.

Report of a study using phantom materials, and clinical experience with simultaneous radio-hyperthermotherapy. / Kuroda, Masahiro; Inamura, K.; Tahara, S.; Mimura, S.; Mikami, Y.; Kawasaki, S.; Hiraki, Y.

In: Acta Medica Okayama, Vol. 46, No. 6, 12.1992, p. 417-426.

Research output: Contribution to journalArticle

Kuroda, M, Inamura, K, Tahara, S, Mimura, S, Mikami, Y, Kawasaki, S & Hiraki, Y 1992, 'Report of a study using phantom materials, and clinical experience with simultaneous radio-hyperthermotherapy.', Acta Medica Okayama, vol. 46, no. 6, pp. 417-426.
Kuroda, Masahiro ; Inamura, K. ; Tahara, S. ; Mimura, S. ; Mikami, Y. ; Kawasaki, S. ; Hiraki, Y. / Report of a study using phantom materials, and clinical experience with simultaneous radio-hyperthermotherapy. In: Acta Medica Okayama. 1992 ; Vol. 46, No. 6. pp. 417-426.
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