Repeated dose and reproductive/developmental toxicity of perfluoroundecanoic acid in rats

Mika Takahashi, Shigeru Ishida, Mutsuko Hirata-Koizumi, Atsushi Ono, Akihiko Hirose

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Perfluoroalkyl acids (PFAAs) are environmental contaminants that have received attention because of their possible effects on wildlife and human health. In order to obtain initial risk information on the toxicity of perfluoroundecanoic acid (PFUA), we conducted a combined repeated dose toxicty study with the reproduction/developmental toxicity screening test (OECD test guideline 422). PFUA was administered by gavage to rats at 0 (vehicle: corn oil), 0.1, 0.3 or 1.0 mg/kg/day. At 1.0 mg/kg/day, body weight gain was inhibited in both sexes, and there was a decrease in fibrinogen in both sexes and shortening of the activated partial thromboplastin time in males. An increase in blood urea nitrogen and a decrease in total protein in both sexes and increases in alkaline phosphatase and alanine transaminase and a decrease in albumin in males were observed at 1.0 mg/kg/day. Liver weight was increased in males at 0.3 mg/kg/day and above and in females at 1.0 mg/kg/day, and this change was observed after a recovery period. In both sexes, centrilobular hypertrophy of hepatocytes was observed at 0.3 mg/kg/day and above and focal necrosis was observed at 1.0 mg/kg/day. In reproductive/developmental toxicity, body weight of pups at birth was lowered and body weight gain at 4 days after birth was inhibited at 1.0 mg/kg/day, while no dose-related changes were found in the other parameters. Based on these findings, the no observed adverse effect levels (NOAELs) for the repeated dose and reproductive/developmental toxicity were considered to be 0.1 mg/kg/day and 0.3 mg/kg/day, respectively.

Original languageEnglish
Pages (from-to)97-108
Number of pages12
JournalJournal of Toxicological Sciences
Volume39
Issue number1
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Toxicity
Rats
Body Weight
Weight Gain
Parturition
No-Observed-Adverse-Effect Level
Toxicity Tests
Corn Oil
Partial Thromboplastin Time
Blood Urea Nitrogen
Thromboplastin
Alanine Transaminase
Liver
Fibrinogen
Hypertrophy
Reproduction
Alkaline Phosphatase
Urea
Hepatocytes
Albumins

Keywords

  • Perfluoroundecanoic acid
  • Rat
  • Repeated dose toxicity
  • Reproductive and developmental toxicity
  • Screening test

ASJC Scopus subject areas

  • Toxicology

Cite this

Repeated dose and reproductive/developmental toxicity of perfluoroundecanoic acid in rats. / Takahashi, Mika; Ishida, Shigeru; Hirata-Koizumi, Mutsuko; Ono, Atsushi; Hirose, Akihiko.

In: Journal of Toxicological Sciences, Vol. 39, No. 1, 2014, p. 97-108.

Research output: Contribution to journalArticle

Takahashi, Mika ; Ishida, Shigeru ; Hirata-Koizumi, Mutsuko ; Ono, Atsushi ; Hirose, Akihiko. / Repeated dose and reproductive/developmental toxicity of perfluoroundecanoic acid in rats. In: Journal of Toxicological Sciences. 2014 ; Vol. 39, No. 1. pp. 97-108.
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